6 research outputs found
Cardiac and renal function in a large cohort of amateur marathon runners
Background Participation of amateur runners in endurance races continues to
increase. Previous studies of marathon runners have raised concerns about
exercise-induced myocardial and renal dysfunction and damage. In our pooled
analysis, we aimed to characterize changes of cardiac and renal function after
marathon running in a large cohort of mostly elderly amateur marathon runners.
Methods A total of 167 participants of the BERLIN-MARATHON (female n = 89,
male n = 78; age = 50.3 ± 11.4 years) were included and cardiac and renal
function was analyzed prior to, immediately after and 2 weeks following the
race by echocardiography and blood tests (including cardiac troponin T, NT-
proBNP and cystatin C). Results Among the runners, 58% exhibited a significant
increase in cardiac biomarkers after completion of the marathon. Overall, the
changes in echocardiographic parameters for systolic or diastolic left and
right ventricular function did not indicate relevant myocardial dysfunction.
Notably, 30% of all participants showed >25% decrease in cystatin C-estimated
glomerular filtration rate (GFR) from baseline directly after the marathon; in
8%, we observed a decline of more than 50%. All cardiac and renal parameters
returned to baseline ranges within 2 weeks after the marathon. Conclusions The
increase in cardiac biomarkers after completing a marathon was not accompanied
by relevant cardiac dysfunction as assessed by echocardiography. After the
race, a high proportion of runners experienced a decrease in cystatin
C-estimated GFR, which is suggestive of transient, exercise-related alteration
of renal function. However, we did not observe persistent detrimental effects
on renal function
Single beat 3D echocardiography for the assessment of right ventricular dimension and function after endurance exercise: Intraindividual comparison with magnetic resonance imaging
<p>Abstract</p> <p>Background</p> <p>Our study compares new single beat 3D echocardiography (sb3DE) to cardiovascular magnetic resonance imaging (CMR) for the measurement of right ventricular (RV) dimension and function immediately after a 30 km run. This is to validate sb3DE against the "gold standard" CMR and to bring new insights into acute changes of RV dimension and function after endurance exercise.</p> <p>Methods</p> <p>21 non-elite male marathon runners were examined by sb3DE (Siemens ACUSON SC2000, matrix transducer 4Z1c, volume rates 10-29/s), CMR (Siemens Magnetom Avanto, 1,5 Tesla) and blood tests before and immediately after each athlete ran 30 km. The runners were not allowed to rehydrate after the race. The order of sb3DE and CMR examination was randomized.</p> <p>Results</p> <p>Sb3DE for the acquisition of RV dimension and function was feasible in all subjects. The decrease in mean body weight and the significant increase in hematocrit indicated dehydration. RV dimensions measured by CMR were consistently larger than measured by sb3DE.</p> <p>Neither sb3DE nor CMR showed a significant difference in the RV ejection fraction before and after exercise. CMR demonstrated a significant decrease in RV dimensions. Measured by sb3DE, this decrease of RV volumes was not significant.</p> <p>Conclusion</p> <p>First, both methods agree well in the acquisition of systolic RV function. The dimensions of the RV measured by CMR are larger than measured by sb3DE. After exercise, the RV volumes decrease significantly when measured by CMR compared to baseline.</p> <p>Second, endurance exercise seems not to induce acute RV dysfunction in athletes without rehydration.</p
Increased longitudinal contractility and diastolic function at rest in well-trained amateur Marathon runners: a speckle tracking echocardiography study
Galectin-3 increase in endurance athletes
Background Galectin-3 is a new and promising biomarker for heart failure and myocardial fibrosis. Although endurance exercise is a crucial element in cardiovascular disease prevention, the relationship between exercise and plasma levels of galectin-3 is still unknown. To date, the relationship between regular exercise and myocardial fibrosis is not fully understood. This study investigates the relationship between endurance exercise and plasma levels of galectin-3. Methods Twenty-one male, healthy non-elite marathon runners were examined before and within 1 hour after a strenuous run of 30km after 4-day training abstinence. Examination included blood samples for galectin-3, echocardiography, and cardiac magnetic resonance imaging (CMR). In addition, to distinguish between cardiac or skeletal muscular origin of galectin-3, 27 C57Bl/6J mice performing voluntary wheel running and 25 sedentary mice were analysed. Results Plasma galectin-3 in endurance athletes increased from baseline to post exercise (12.83.4ng/ml to 19.9 +/- 3.9ng/ml, p Conclusions Plasma galectin-3 is substantially elevated in endurance athletes after running but does not correlate with cardiac function, other biomarkers, or myocardial fibrosis. In mice, we demonstrate that galectin-3 increase during endurance exercise originates primarily from skeletal muscle