Can a Point-of-Care Troponin I Assay be as Good as a Central Laboratory Assay? A MIDAS Investigation.

BACKGROUND: We aimed to compare the diagnostic accuracy of the Alere Triage Cardio3 Tropinin I (TnI) assay (Alere, Inc., USA) and the PathFast cTnI-II (Mitsubishi Chemical Medience Corporation, Japan) against the central laboratory assay Singulex Erenna TnI assay (Singulex, USA). METHODS: Using the Markers in the Diagnosis of Acute Coronary Syndromes (MIDAS) study population, we evaluated the ability of three different assays to identify patients with acute myocardial infarction (AMI). The MIDAS dataset, described elsewhere, is a prospective multicenter dataset of emergency department (ED) patients with suspected acute coronary syndrome (ACS) and a planned objective myocardial perfusion evaluation. Myocardial infarction (MI) was diagnosed by central adjudication. RESULTS: The C-statistic with 95% confidence intervals (CI) for diagnosing MI by using a common population (n=241) was 0.95 (0.91-0.99), 0.95 (0.91-0.99), and 0.93 (0.89-0.97) for the Triage, Singulex, and PathFast assays, respectively. Of samples with detectable troponin, the absolute values had high Pearson (R(P)) and Spearman (R(S)) correlations and were R(P)=0.94 and R(S)=0.94 for Triage vs Singulex, R(P)=0.93 and R(S)=0.85 for Triage vs PathFast, and R(P)=0.89 and R(S)=0.73 for PathFast vs Singulex. CONCLUSIONS: In a single comparative population of ED patients with suspected ACS, the Triage Cardio3 TnI, PathFast, and Singulex TnI assays provided similar diagnostic performance for MI

IMPACT: The Journal of the Center for Interdisciplinary Teaching and Learning. Volume 10, Issue 2, Summer 2021

Impact: The Journal of the Center for Interdisciplinary Teaching & Learning is a peer-reviewed, biannual online journal that publishes scholarly and creative non-fiction essays about the theory, practice, and assessment of interdisciplinary education. Impact is produced by the Center for Interdisciplinary Teaching & Learning at Boston University College of General Studies. Impact accepts submissions throughout the year and publishes issues in February and July. Please submit your essays for consideration at https:// citl.submittable.com/submit. Impact provides free and open access to all of its research publications. There is no charge to authors for publication, and the journal abides by a CC-BY license. Authors published in Impact retain copyright on their articles, except for any third-party images and other materials added by Impact, which are subject to copyright of their respective owners. Authors are therefore free to disseminate and re-publish their articles, subject to any requirements of third-party copyright owners and subject to the original publication being fully cited. Visitors may download and forward articles subject to the citation requirements; all copyright notices must be displayed. If readers want to search by journal subject they might use these words: education, graduate, undergraduate, interdisciplinary, disciplines, curriculum, higher education.The theme of this issue is interdisciplinary approaches to, or including, the sciences. STEM disciplines like chemistry, biology, physics, computer science, and math are often taught as separate and distinct from the humanities. The concept of STEAM (STEM + Arts) has attempted to make STEM subjects more interdisciplinary, allowing students to interact with the material from different perspectives. The essays in this issue explore unique ways to design and implement interdisciplinary curricula that combine sciences and humanities/arts

Detective Fiction

This is one of hundreds of 60-second radio spots created by the Center for East Asian Studies (CEAS) for Kansas Public Radio (KPR). The purpose of this outreach program is to introduce the people of Kansas to the culture and current issues of East Asia.Broadcast Transcript: Detective fiction in the West celebrates its 100th anniversary this year. Of course, the detective genre has been around for way longer here in China. The Casebook of Judge Dee was written about 300 years ago. Robert van Gulik, a Dutch diplomat, translated three cases into English in 1976 and then went on to create stories of his own. The real Judge Dee was a canny Confucian magistrate back in the Tang Dynasty. Dee used some techniques that are amazingly modern: forensics, stoolies, stakeouts. He also relied on some resources less acceptable to the modern sleuth: ghosts, portents and torture. Still, given his success, modern detectives could do worse than ask themselves: what would Dee do? #ceas #china #johnson #tsutsui #shroc

One Little King

This is one of hundreds of 60-second radio spots created by the Center for East Asian Studies (CEAS) for Kansas Public Radio (KPR). The purpose of this outreach program is to introduce the people of Kansas to the culture and current issues of East Asia.Broadcast Transcript: China's one-child policy has accomplished what it set out to do: decrease the population of the world's most populous nation, but it has also changed the typical family configuration and created the "four grandparents, two parents, and one little king" family. Americans might well equate this only child set up with "spoiled brat" and, yes, there's a certain level of indulgence that single Chinese children are enjoying these days, but today's child will be tomorrow's adult and the Chinese never lose sight of that: a single child may be showered with the wealth of parents and grandparents, but in a society where social security has not yet extended to a significant portion of the population, he is also under a great responsibility to care for those parents. Long live the king. #ceas #china #shrock #tsutsu

Formation of Alternating trans-A-alt-B Copolymers through Ring-Opening Metathesis Polymerization Initiated by Molybdenum Imido Alkylidene Complexes

Ring-opening metathesis polymerization (ROMP) is used to prepare trans-poly(A-alt-B) polymers from a 1:1 mixture of A and B where A is a cyclic olefin such as cyclooctene (A[subscript 1]) or cycloheptene (A[subscript 2]) and B is a large norbornadiene or norbornene derivative such as 2,3-dicarbomethoxy-7-isopropylidenenorbornadiene (B[subscript 1]) or dimethylspirobicyclo[2.2.1]hepta-2,5-diene-2,3-dicarboxylate-7,1'cyclopropane (B[subscript 2]). The most successful initiators that were examined are of the type Mo(NR)(CHCMe[subscript 2]Ph)[OCMe(CF[subscript 3])[subscript 2]][subscript 2] (R = 2,6-Me[subscript 2]C[subscript 6]H[subscript 3] (1) or 2,6-iPr[subscript 2]C[subscript 6]H[subscript 3] (2)). The trans configuration of the AB linkages is proposed to result from the steric demand of B. Both anti-MB and syn-MB alkylidenes are observed during the copolymerization, where B was last inserted into a Mo=C bond, although anti-MB dominates as the reaction proceeds. Anti-MB is lower in energy than syn-MB, does not react readily with either A or B, and interconverts slowly with syn-MB through rotation about the Mo=C bond. Syn-MB does not readily react with B, but it does react slowly with A (rate constant ~1 M[superscript -1] s [superscript -1]) to give anti-MA and one trans-AB linkage. Anti-MA then reacts with B (rate constant ~300 M[superscript -1] s[superscript -1] or larger) to give syn-MB and the second trans-AB linkage. The reaction has been modeled using experimental data in order to obtain the estimated rate constants above. The reaction between anti-MA and A is proposed to give rise to AA linkages, but AA dyads can amount to <5%. Several other possible A and B monomers, initiators, and conditions were explored.United States. Dept. of Energy (Grant DE-FG02-86ER13564

Synthesis of cis,syndiotactic-A-alt-B Copolymers from Enantiomerically Pure Endo-2-Substituted-5,6-Norbornenes

Cis,syndiotactic A-alt-B copolymers, where A and B are two enantiomerically pure endo-2-substituted-5,6-norbornenes with “opposite” chiralities of the endo-2-substituted-5,6-norbornene skeleton, can be prepared using Mo(N-2,6-Me[subscript 2]C[subscript 6]H[subscript 3])(CHCMe[subscript 2]Ph)(OHMT)(pyrrolide) (1) as the initiator (OHMT = O-2,6-Mesityl[subscript 2]C[subscript 6]H[subscript 3]). Formation of a high percentage of A-alt-B dyads is proposed to rely on an inversion of chirality at the metal with each propagating step and a kinetically preferred diastereomeric relationship between a given chirality at the metal in propagating species and the chirality of the endo-2-substituted-5,6-norbornene skeleton. We also demonstrate that A-alt-B copolymers can be modified to give new variations which may not be accessible through direct copolymerization.United States. Department of Energy (DE-FG02-86ER13564

Synthesis of Cis,syndiotactic A-alt-B Copolymers from Two Enantiomerically Pure Trans-2,3-Disubstituted-5,6-Norbornenes

Cis, syndiotactic A-alt-B copolymers, where A and B are two enantiomerically pure trans-2,3-disubstituted- 5,6-norbornenes with "opposite" chiralities, can be prepared with stereogenic-at-metal initiators of the type M(NR)- (CHR')(OR")(pyrrolide). Formation of a high percentage of alternating AB copolymer linkages relies on an inversion of chirality at the metal with each propagating step and a relatively fast formation of an AB sequence as a consequence of a preferred diastereomeric relationship between the chirality at the metal and the chirality of the monomer. This approach to formation of an alternating AB copolymer contrasts dramatically with the principle of forming AB copolymers from achiral monomers and catalysts.United States. Department of Energy (DE-FG02- 86ER13564)

Synthesis of Cis,syndiotactic A-alt-B Copolymers from Two Enantiomerically Pure Trans-2,3-Disubstituted-5,6-Norbornenes.

Cis,syndiotacticA-alt-B copolymers, where A and B are two enantiomerically pure trans-2,3-disubstituted-5,6-norbornenes with "opposite" chiralities, can be prepared with stereogenic-at-metal initiators of the type M(NR)(CHR')(OR")(pyrrolide). Formation of a high percentage of alternating AB copolymer linkages relies on an inversion of chirality at the metal with each propagating step and a relatively fast formation of an AB sequence as a consequence of a preferred diastereomeric relationship between the chirality at the metal and the chirality of the monomer. This approach to formation of an alternating AB copolymer contrasts dramatically with the principle of forming AB copolymers from achiral monomers and catalysts

Synthesis of Cis,syndiotactic A-alt-B Copolymers from Two Enantiomerically Pure Trans-2,3-Disubstituted-5,6-Norbornenes.

Cis,syndiotacticA-alt-B copolymers, where A and B are two enantiomerically pure trans-2,3-disubstituted-5,6-norbornenes with "opposite" chiralities, can be prepared with stereogenic-at-metal initiators of the type M(NR)(CHR')(OR")(pyrrolide). Formation of a high percentage of alternating AB copolymer linkages relies on an inversion of chirality at the metal with each propagating step and a relatively fast formation of an AB sequence as a consequence of a preferred diastereomeric relationship between the chirality at the metal and the chirality of the monomer. This approach to formation of an alternating AB copolymer contrasts dramatically with the principle of forming AB copolymers from achiral monomers and catalysts