48 research outputs found
Zoonotic diseases and human health: The human influenza example
Over the past few decades a large number of new and emerging infectious diseases have been recognised in humans, partly because of improved diagnostic technologies and increased awareness and also, partly because of dynamic ecological changes between human hosts and their exposure to animals and the environment (Coker et al. 2011). Some 177 new pathogenic organisms have been recognised to be ‘emerging’, that is, have newly arisen or been newly introduced into human populations; almost three quarters of these, 130 (73%), have come from zoonotic origins (Cascio et al. 2011; Cutler, Fooks & Van Der Poel 2010; Taylor, Latham & Woolhouse 2001; Woolhouse & Gowtage-Sequeria 2005). One of the most prevalent and important human infectious disease is influenza, a disease responsible globally for a quarter million deaths annually. In the USA alone the toll from influenza is estimated at 36 000 deaths and 226 000 hospitalisations, and it ranks as the most important cause of vaccine preventable mortality in that country (CDC 2010). The epidemiological behaviour of human influenza clearly defines it as an emerging infectious disease and the recent understanding of its zoonotic origins has contributed much to the understanding of its behaviour in humans (Fauci 2006)
Afriflu2—Second international workshop on influenza vaccination in the African continent—8 November 2012, Cape Town (South Africa)
AbstractThe second meeting of the Afriflu conferences took place in Cape Town, South Africa, with over 60 participants from 15 countries in Africa and also outside the continent. Significant progress in surveillance has been made in better understanding the illness burden of influenza on the continent, which limited evidence suggests is greater than that in the developed world. In southern Africa HIV and TB coinfections play a major role in increasing hospitalisation and mortality, while elsewhere in Africa other cofactors still need to be determined.There is currently no indigenous vaccine production in sub-Saharan Africa and only one facility, based in South Africa, capable of filling imported bulk. Innovative vaccine strategies will need to be explored, such as maternal immunisation, and also the possibility of other influenza vaccine options, such as live attenuated influenza vaccine for young children. Sustained indigenous vaccine production is essential for the continent to have vaccine security in the event of a pandemic even though establishing local production faces considerable challenges especially ensuring adequate markets on the continent. There is an urgent need to develop effective communication messages for decision makers as well as healthcare workers addressing the importance of influenza even in the face of the major competing health burdens of the continent
Advances in childhood immunisation in South Africa: where to now? Programme managers’ views and evidence from systematic reviews.
Background: The Expanded Programme on Immunisation (EPI) is one of the most powerful and cost-effective
public health programmes to improve child survival. We assessed challenges and enablers for the programme in
South Africa, as we approach the 2015 deadline for the Millennium Development Goals.
Methods: Between September 2009 and September 2010 we requested national and provincial EPI managers in
South Africa to identify key challenges facing EPI, and to propose appropriate solutions. We collated their responses
and searched for systematic reviews on the effectiveness of the proposed solutions; in the Health Systems Evidence, Cochrane Library, and PubMed electronic databases. We screened the search outputs, selected systematic reviews, extracted data, and assessed the quality of included reviews (using AMSTAR) and the quality of the evidence (using GRADE) in duplicate; resolving disagreements by discussion and consensus.
Results: Challenges identified by EPI managers were linked to healthcare workers (insufficient knowledge of vaccines and immunisation), the public (anti-immunisation rumours and reluctance from parents), and health system (insufficient financial and human resources). Strategies proposed by managers to overcome the challenges include training, supervision, and audit and feedback; strengthening advocacy and social mobilisation; and sustainable EPI funding schemes, respectively. The findings from reliable systematic reviews indicate that interactive educational meetings, audit and feedback, and supportive supervision improve healthcare worker performance. Structured and interactive communication tools probably increase parents’ understanding of immunisation; and reminders and recall, use of community health workers, conditional cash transfers, and mass media interventions probably increase immunisation coverage. Finally, a national social health insurance scheme is a potential EPI financing mechanism; however, given the absence of high-quality evidence of effects, its implementation should be pilot-tested and the impacts and costs rigorously monitored.
Conclusion: In line with the Millennium Development Goals, we have to ensure that our children’s right to health,
development and survival is respected, protected and promoted. EPI is central to this vision. We found numerous
promising strategies for improving EPI performance in South Africa. However, their implementation would need to
be tailored to local circumstances and accompanied by high-quality monitoring and evaluation. The strength of our
approach comes from having a strong framework for interventions before looking for systematic reviews. Without a
framework, we would have been driven by what reviews have been done and what is easily researchable; rather
than the values and preferences of key immunisation stakeholders
Advances in childhood immunisation in South Africa: where to now? Programme managers’ views and evidence from systematic reviews
Measles outbreak in South Africa: epidemiology of laboratory-confirmed measles cases and assessment of intervention, 2009-2011
BACKGROUND: Since 1995, measles vaccination at nine and 18 months has been routine in South Africa; however, coverage
seldom reached .95%. We describe the epidemiology of laboratory-confirmed measles case-patients and assess the impact
of the nationwide mass vaccination campaign during the 2009 to 2011 measles outbreak in South Africa.
METHODS: Serum specimens collected from patients with suspected-measles were tested for measles-specific IgM antibodies
using an enzyme-linked immunosorbent assay and genotypes of a subset were determined. To estimate the impact of the
nationwide mass vaccination campaign, we compared incidence in the seven months pre- (1 September 2009–11 April
2010) and seven months post-vaccination campaign (24 May 2010–31 December 2010) periods in seven provinces of South
Africa.
RESULTS: A total of 18,431 laboratory-confirmed measles case-patients were reported from all nine provinces of South Africa
(cumulative incidence 37 per 100,000 population). The highest cumulative incidence per 100,000 population was in children
aged ,1 year (603), distributed as follows: ,6 months (302/100,000), 6 to 8 months (1083/100,000) and 9 to 11 months
(724/100,000). Forty eight percent of case-patients were 40 years. A single strain of measles virus (genotype B3) circulated
throughout the outbreak. Prior to the vaccination campaign, cumulative incidence in the targeted vs. non-targeted age
group was 5.9-fold higher, decreasing to 1.7 fold following the campaign (P,0.001) and an estimated 1,380 laboratoryconfirmed
measles case-patients were prevented.
CONCLUSION: We observed a reduction in measles incidence following the nationwide mass vaccination campaign even
though it was conducted approximately one year after the outbreak started. A booster dose at school entry may be of value
given the high incidence in persons .5 years.Our acknowledgements go to the Department of Health South Africa,
National, provincial and districts, the South African Field Epidemiology
and Laboratory Training Programme (SAFELTP), for ongoing support in
surveillance and outbreak activities; Division of Epidemiology (Tsakani
Nkuna, Kelebogile Lebogang Motsepe) and Virology (Londiwe Mahlaba,
Mduduzi Buthelezi, Nomfundo Radebe, Muzi Hlanzi, Wayne Howard) at
the NICD-NHLS for data management and laboratory testing support
respectively and Private Laboratories for their support and referring
specimens to the NICD.www.plosone.orgam201