462 research outputs found
An illustrated key to Malacostraca (Crustacea) of the Northern Arabian Sea part-V: Isopoda
The northern Arabian Sea Isopod fauna is keyed out, excluding the gulfs fauna. Some terrestrial species are also included. Previous accounts and recent collections
from Pakistan mainly at Karachi have turned up 7 suborders, 18 families, 76 genera and 12 1 species. There 5 are new records from Pakistan. For each species, there is an
illustration and information of its reporter from the area and on its host, if parastic. The source of illustration is also given
A novel mutation in the miR-128b gene reduces miRNA processing and leads to glucocorticoid resistance of MLL-AF4 Acute Lymphocytic Leukemia cells
MLL-AF4 Acute Lymphocytic Leukemia has a poor prognosis, and the mechanisms by which these leukemias develop are not understood despite intensive research based on well-known concepts and methods. MicroRNAs (miRNAs) are a new class of small noncoding RNAs that post-transcriptionally regulate expression of target mRNA transcripts. We recently reported that ectopic expression of miR-128b together with miR-221, two of the miRNAs downregulated in MLL-AF4 ALL, restores glucocorticoid resistance through downregulation of the MLL-AF4 chimeric fusion proteins MLL-AF4 and AF4-MLL that are generated by chromosomal translocation t(4;11). Here we report the identification of new mutations in miR-128b in RS4;11 cells, derived from MLL-AF4 ALL patient. One novel mutation significantly reduces the processing of miR-128b. Finally, this base change occurs in a primary MLL-AF4 ALL sample as an acquired mutation. These results demonstrate that the novel mutation in miR-128b in MLL-AF4 ALL alters the processing of miR-128b and that the resultant downregulation of mature miR-128b contributes to glucocorticoid resistance through the failure to downregulate the fusion oncogenes.National Institutes of Health (U.S.) (NIH Grant R01 DK068348)Netherlands Organization for Scientific ResearchDutch Cancer SocietyJapan Society for the Promotion of Scienc
Flow equation analysis of the anisotropic Kondo model
We use the new method of infinitesimal unitary transformations to calculate
zero temperature correlation functions in the strong-coupling phase of the
anisotropic Kondo model. We find the dynamics on all energy scales including
the crossover behaviour from weak to strong coupling. The integrable structure
of the Hamiltonian is not used in our approach. Our method should also be
useful in other strong-coupling models since few other analytical methods allow
the evaluation of their correlation functions on all energy scales.Comment: 4 pages RevTeX, 2 eps figures include
Asymptotically exact solution of a local copper-oxide model
We present an asymptotically exact solution of a local copper-oxide model
abstracted from the multi-band models. The phase diagram is obtained through
the renormalization-group analysis of the partition function. In the strong
coupling regime, we find an exactly solved line, which crosses the quantum
critical point of the mixed valence regime separating two different
Fermi-liquid (FL) phases. At this critical point, a many-particle resonance is
formed near the chemical potential, and a marginal-FL spectrum can be derived
for the spin and charge susceptibilities.Comment: 11 pages, 1 postcript figure is appended as self-extracting archive,
Revtex 2.0, ICTP preprint 199
- …