62 research outputs found
Pensioen wijzigen jegens slapers en pensioengerechtigden
Naar aanleiding van de eerdere publicatie van auteurs inzake 'Wijzigingsvraagstukken in de pensioendriehoek'(TPV 2012/42), is een reactie verschenen van Breuker. In dit artikel wordt gereageer op het artikel van Breuker en verduidelijken auteurs hun standpunt over de juridische (on)houdbaarheid van (1) de uitewerkte rechtsverhouding en (2) pensioenwijzigingen jegens slapers en pensioengerechtigden. De conclusie luidt dat wijziging van opgebouwd pensioen jegens slapers en pensioengerechtigden - inclusief onvoorwaardelijke indexatie - moeilijk is maar wel mogelijk. Een dergelijke wijziging geschiedt onder de Pensioenwet binnen de marges van de wet: via waardeoverdracht of korten. Het door de wetgever gestimuleerde invaren is daar een voorbeeld van. Onder de (voormalige) Pensioen- en Spaarfondsenwet ligt dit anders volgens auteurs. Er gold geen wettelijke beperking ten aanzien van het voorwaardelijk maken van onvoorwaardelijke indexatie. Het pad om de wijzigingen rechtsgeldig door te voeren jegens slapers en pensioengerechtigden is nog steeds hobbelig en onzeker
MicroRNA expression in tumor cells from Waldenstrom's macroglobulinemia reflects both their normal and malignant cell counterparts
MicroRNAs (miRNAs) are involved in the regulation of many cellular processes including hematopoiesis, with the aberrant expression of differentiation-stage specific miRNA associated with lymphomagenesis. miRNA profiling has been essential for understanding the underlying biology of many hematological malignancies; however the miRNA signature of the diverse tumor clone associated with Waldenstrom's macroglobulinemia (WM), consisting of B lymphocytes, plasmacytes and lymphoplasmacytic cells, has not been characterized. We have investigated the expression of over 13ā000 known and candidate miRNAs in both CD19+ and CD138+ WM tumor cells, as well as in their malignant and non-malignant counterparts. Although neither CD19+ nor CD138+ WM cells were defined by a distinct miRNA profile, the combination of all WM cells revealed a unique miRNA transcriptome characterized by the dysregulation of many miRNAs previously identified as crucial for normal B-cell lineage differentiation. Specifically, miRNA-9*/152/182 were underexpressed in WM, whereas the expression of miRNA-21/125b/181a/193b/223/363 were notably increased (analysis of variance; P<0.0001). Future studies focusing on the effects of these dysregulated miRNAs will provide further insight into the mechanisms responsible for the pathogenesis of WM
Wildgroei bewegingsprogramma's maakt aanbod onoverzichtelijk
In dit derde en laatste artikel in een serie over bewegingsprogramma's in het bedrijfsleven wordt een overzicht gegeven van de aard van leveranciers, die deze 'gezond bewegen' programma's aan bedrijven aanbieden. Ook wordt de inhoud van die programma's belicht
The effect of mature plant resistance in sugar beet (Beta vulgaris spp. vulgaris) on survival, fecundity and behaviour of green peach aphids (Myzus persicae)
Several studies have shown the negative effects of mature plant resistance (MPR) on aphids in sugar beet, which is correlated to the formation of black deposits in their stomach. However, the underlying mechanism of MPR still needs to be elucidated, by understanding the toxicity effects of MPR on aphids and the role of the plant phenological stage and the environment. Here, we report that MPR in sugar beet does not only affect Myzus persicae mortality rate and the formation of a black deposit in the aphid stomach, but also aphid fecundity and behaviour. In addition, experiments in climate-controlled and field settings showed quantitative variation in MPR to M. persicae between six genotypes of sugar beet. Our results indicate that environmental effects, such as temperature, play a major role in MPR and underscore the importance of proper climate-controlled experiments for investigating MPR. In climate-controlled experiments, 83.3% of aphids on old leaves developed a black deposit, in contrast to only 16.8% of aphids on young leaves. This shows that not only plant age, but also leaf age plays a major role in the intensity of MPR. Further research will be needed to identify the underlying mechanism, before MPR can be used as a viable and sustainable solution to aphid pests in sugar beet
Expansion of mesenchymal stem cells using a microcarrier-based cultivation system: growth and metabolism
For the continuous and fast expansion of mesenchymal stem cells (MSCs), microcarriers have gained increasing interest. The aim of this study was to evaluate the growth and metabolism profiles of MSCs, expanded in a microcarrier-based cultivation system. We investigated various cultivation conditions to expand goat mesenchymal stem cells on Cytodex 1 microcarriers. These conditions differed in feeding regime, i.e. the addition of fresh proliferation medium, with or without new microcarriers. For all conditions, cell attachment, cell proliferation, energy source consumption, metabolite production, and cell distribution on the microcarriers were studied. Attachment efficiencies of 40% were obtained followed by successful expansion up to 15 cultivation days. Depending on the feeding regime, an exponential growth, stationary growth, and decline growth phase could be distinguished. Addition of 30% fresh medium containing microcarriers every three days showed the longest continuous proliferation of goat MSCs on microcarriers. This feeding regime has the advantage that metabolites, such as ammonia, are diluted and that new energy sources, such as glucose and glutamine, and additional surface area are provided to the cells. In addition, by adding extra microcarriers a more homogenous cell distribution on the microcarriers is obtained as a result of bead-to-bead transfer. A correlation between nutrient consumption, metabolite production and cell growth was observed. The decreasing yield of lactate from glucose over time indicated a possible shift in cellular metabolism
Pensioen wijzigen jegens slapers en gepensioneerden. Moeilijk, maar niet onmogelijk
Wij verwelkomen de reactie van Hans Breuker op ons artikel āWijzigingsvraagstukken in de pensioendriehoekā (TPV 2012/42). Beantwoording van de fundamentele vraag of en hoe wijziging van de pensioenregeling jegens slapers en pensioengerechtigden mogelijk is, is van groot praktisch belang. De golf aan indexatiejurisprudentie en het invaren van onvoorwaardelijke pensioenaanspraken en -rechten naar een nieuw pensioencontract met voorwaardelijke pensioenaanspraken illustreren dat. Wij maken graag gebruik van de gelegenheid om te reageren op Breuker en ons standpunt over de juridische (on)houdbaarheid van (1) de uitgewerkte rechtsverhouding en (2) pensioenwijzigingen jegens slapers en pensioengerechtigden te verduidelijken
Extensive genetic alterations of the HLA region, including homozygous deletions of HLA class II genes in B-cell lymphomas arising in immune-privileged sites
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