420 research outputs found

    The Role of Futureproofing in the Management of Infrastructural Assets

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    Ensuring long-term value from infrastructure is essential for a sustainable economy. In this context, futureproofing involves addressing two broad issues: i. Ensuring the ability of infrastructure to be resilient to unexpected or uncontrollable events e.g. extreme weather events; and ii. Ensuring the ability to adapt to required changes in structure and / or operations of the infrastructure in the future e.g. expansion of capacity, change in usage mode or volumes. Increasingly, in their respective roles, infrastructure designers/builders and owners/operators are being required to develop strategies for futureproofing as part of the life cycle planning for key assets and systems that make up infrastructure. In this paper, we report on a preliminary set of studies aimed at exploring the following issues related to infrastructure / infrastructure systems: • What is intended by the futureproofing of infrastructural assets? • Why and when to futureproof critical infrastructure? • How can infrastructure assets and systems be prepared for uncertain futures? • How can futureproofing be incorporated into asset management practice? In order to seek answers to the above questions, the Cambridge Centre for Smart Infrastructure and Construction (CSIC) has conducted two industrial workshops bringing together leading practitioners in the UK infrastructure and construction sectors, along with government policy makers. This paper provides an initial summary of the findings from the workshops (part presentation, part working sessions), and proposes a simple framework for linking futureproofing into broader asset management considerations. To begin, an overview of futureproofing and motivate the need for futureproofing infrastructure assets is provided. Following this, an approach to futureproofing infrastructure portfolios is presented that organisations in the infrastructure sector can use. Key barriers to futureproofing are also presented before examining the ISO 55001 asset management standard to highlight the interplay between futureproofing and infrastructural asset management. Finally, different ways by which an effective futureproofing strategy can enhance the value of infrastructure are examined

    The phonology of Yuanga: a language of New Caledonia

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    From BIM towards digital twin: Strategy and future development for smart asset management

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    With the rising adoption of Building Information Model (BIM) for asset management within architecture, engineering, construction and owner-operated (AECO) sector, BIM-enabled asset management has been increasingly attracting more attentions in both research and practice. This study provides a comprehensive review and analysis of the state-of-the-art latest research and industry standards development that impact upon BIM and asset management within the operations and maintenance (O&M) phase. However, BIM is not always enough in whole-life cycle asset management, especially in the O&M phase. Therefore, a framework for future development of smart asset management is proposed, integrating the concept of Digital Twin (DT). DT integrates artificial intelligence, machine learning and data analytics to create dynamic digital models that are able to learn and update the status of the physical counterpart from multiple sources. The findings will contribute to inspiring novel research ideas and promote widespread adoption of smart DT-enabled asset management within the O&M phase

    Papers in New Guinea Linguistics No. 26

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    Testosterone therapy and cardiovascular events among men: a systematic review and meta-analysis of placebo-controlled randomized trials

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    Background Testosterone therapy is increasingly promoted. No randomized placebo-controlled trial has been implemented to assess the effect of testosterone therapy on cardiovascular events, although very high levels of androgens are thought to promote cardiovascular disease. Methods A systematic review and meta-analysis was conducted of placebo-controlled randomized trials of testosterone therapy among men lasting 12+ weeks reporting cardiovascular-related events. We searched PubMed through the end of 2012 using “(“testosterone” or “androgen”) and trial and (“random*”)” with the selection limited to studies of men in English, supplemented by a bibliographic search of the World Health Organization trial registry. Two reviewers independently searched, selected and assessed study quality with differences resolved by consensus. Two statisticians independently abstracted and analyzed data, using random or fixed effects models, as appropriate, with inverse variance weighting. Results Of 1,882 studies identified 27 trials were eligible including 2,994, mainly older, men who experienced 180 cardiovascular-related events. Testosterone therapy increased the risk of a cardiovascular-related event (odds ratio (OR) 1.54, 95% confidence interval (CI) 1.09 to 2.18). The effect of testosterone therapy varied with source of funding (P-value for interaction 0.03), but not with baseline testosterone level (P-value for interaction 0.70). In trials not funded by the pharmaceutical industry the risk of a cardiovascular-related event on testosterone therapy was greater (OR 2.06, 95% CI 1.34 to 3.17) than in pharmaceutical industry funded trials (OR 0.89, 95% CI 0.50 to 1.60). Conclusions The effects of testosterone on cardiovascular-related events varied with source of funding. Nevertheless, overall and particularly in trials not funded by the pharmaceutical industry, exogenous testosterone increased the risk of cardiovascular-related events, with corresponding implications for the use of testosterone therapy
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