Order of Magnitude Beam Current Improvement in Compact Cyclotrons

There is great need for high intensity proton beams from compact particle accelerators in particle physics, medical isotope production, and materials- and energy-research. To this end, the DAE$\delta$ALUS/IsoDAR collaboration is developing a compact isochronous cyclotron that will be able to deliver 10 mA of protons - an order of magnitude higher than on-market compact cyclotrons and a factor four higher than research machines. For the first time, vortex motion is incorporated in the design of a cyclotron, which is key to reaching high extracted beam current. We present high-fidelity simulations of the acceleration of a 5 mA H$_2^+$ beam (equivalent to 10 mA of protons) in this cyclotron, using the particle-in-cell code OPAL, demonstrating the feasibility of constructing this machine. The simulations are based on the latest cyclotron design and through them, we show that sufficient turn separation between the $(\mathrm{N}-1)^{th}$ and $\mathrm{N}^{th}$ turn can be achieved even with initially mismatched beams by careful placement of collimators to scrape away halo particles before the beam energy has reached 1.5 MeV/amu. We describe in detail the process for placement of electrostatic extraction channels. Beam losses on the septa of these channels stay below 50 W with beam quality sufficient for transport to the target. Furthermore, we present an uncertainty quantification of select beam input parameters using machine learning, showing the robustness of the design.Comment: To be submitted to PR

Physical Activity and Nutritional Behaviors with Adults with Intellectual Disabilities

Color poster with text, tables, and images.Current research suggests that adults with intellectual disabilities have a high rate of obesity, physical inactivity, and poor fruit and vegetable intake; yet, no study has examined the interaction of these three components. The purpose of this study was to examine the physical activity (PA) and fruit and vegetable intake of adults with intellectual disabilities to determine if they meet the current recommendations and their impact on obesity.University of Wisconsin--Eau Claire Office of Research and Sponsored Programs

Cosmicflows-4: The Catalog of ∼10,000 Tully–Fisher Distances

International audienceWe present the distances of 9792 spiral galaxies lying within 15,000 km s−1 using the relation between luminosity and rotation rate of spiral galaxies. The sample is dominantly, but not exclusively, drawn from galaxies detected in the course of the ALFALFA H i survey with the Arecibo Telescope. Relations between H i line widths and luminosity are calibrated at SDSS u, g, r, i, z bands and WISE W1 and W2 bands. By exploiting secondary parameters, particularly color indices, we address discrepancies between measured distances at different wave bands with unprecedented detail. We provide a catalog that includes reduced kinematic, photometric, and inclination parameters. We also describe a machine-learning algorithm, based on the random forest technique, that predicts the dust attenuation in spirals lacking infrared photometry. We determine a Hubble Constant value of H 0 = 75.1 ± 0.2(stat.), with potential systematics up to ±3 km s−1 Mpc−1

Dietary Glycemic Load and Cancer Recurrence and Survival in Patients with Stage III Colon Cancer: Findings From CALGB 89803

BACKGROUND: The influence of glycemic load and related measures on survival among colon cancer patients remains largely unknown. METHODS: We conducted a prospective, observational study of 1011 stage III colon cancer patients reporting dietary intake during and 6 months after participation in an adjuvant chemotherapy trial. We examined the influence of glycemic load, glycemic index, fructose, and carbohydrate intakes on cancer recurrence and mortality using Cox proportional hazards regression; all tests of statistical significance were two-sided. RESULTS: Stage III colon cancer patients in the highest quintile of dietary glycemic load experienced an adjusted hazard ratio (HR) for disease-free survival of 1.79 (95% confidence interval [CI] = 1.29 to 2.48), compared with those in the lowest quintile (P (trend) across quintiles <.001). Increased glycemic load was associated with similar detriments in recurrence-free (P (trend) across quintiles <.001) and overall survival (P (trend) across quintiles <.001). These associations differed statistically significant by body mass index (BMI) (P (interaction) =.01). Whereas glycemic load was not associated with disease-free survival in patients with BMI < 25kg/m(2), higher glycemic load was statistically significant associated with worse disease-free survival among overweight or obese participants (BMI ≥ 25kg/m(2); HR = 2.26; 95% CI = 1.53 to 3.32; P (trend) across quintiles <.001). Increasing total carbohydrate intake was similarly associated with inferior disease-free, recurrence-free, and overall survival (P (trend) across quintiles <.001). CONCLUSION: Higher dietary glycemic load and total carbohydrate intake were statistically significant associated with an increased risk of recurrence and mortality in stage III colon cancer patients. These findings support the role of energy balance factors in colon cancer progression and may offer potential opportunities to improve patient survival