Closing the Neutrino "BSM Gap": Physics Potential of Atmospheric Through-Going Muons at DUNE

Many Beyond-Standard Model physics signatures are enhanced in high-energy neutrino interactions. To explore these signatures, ultra-large Cherenkov detectors such as IceCube exploit event samples with charged current muon neutrino interactions > 1 TeV. Most of these interactions occur below the detector volume, and produce muons that enter the detector. However, the large spacing between detectors leads to inefficiency for measuring muons with energies below or near the critical energy of 400 GeV. In response, IceCube has built a densely instrumented region within the larger detector. This provides large samples of well-reconstructed interactions that are contained within the densely instrumented region, extending up to energies of ~50 GeV. This leaves a gap of relatively unexplored atmospheric-neutrino events with energies between 50 GeV and 1 TeV in the ultra-large detectors. In this paper we point out that interesting Beyond Standard Model signatures may appear in this energy window, and that early running of the DUNE far detectors can give insight into new physics that may appear in this range.Comment: 10 pages, 9 figures, 1 tabl

Defect physics of BaCuChF (Ch=S, Se, Te) p-type transparent conductors

Native point defects, defect complexes, and oxygen impurities in BaCuChF were studied using density functional theory calculations, self-consistent thermodynamic simulations, and various experimental techniques. Unintentional p-type conductivity in BaCuChF is explained by the presence of copper vacancies with transition levels in the valence band. These acceptor-like defects are partially compensated by donor-like chalcogen vacancies with transition levels deep in the gap. Chalcogen vacancies also cause the experimentally observed subgap photoluminescence, optical absorption, and persistent photoconductivity in BaCuSF and BaCuSeF. In thermodynamic equilibrium, both copper and chalcogen vacancies have low formation enthalpies and are likely to form defect complexes among themselves and with fluorine interstitials. The calculated Fermi level pinning range in BaCuChF is narrow and located close to the valence band maximum. It makes BaCuChF a suitable transparent p-type contact layer for optoelectronic applications but hinders attempts to fabricate transparent thin-film transistors using this material. Oxygen-related defects do not affect bulk BaCuChF properties but surface oxidation decreases the mean free path of free holes by almost an order of magnitude

Dipole-Coupled Neutrissimo Explanations of the MiniBooNE Excess Including Constraints from MINERvA Data

We revisit models of heavy neutral leptons (neutrissimos) with transition magnetic moments as explanations of the $4.8\sigma$ excess of electron-like events at MiniBooNE. We perform a detailed Monte Carlo-based analysis to re-examine the preferred regions in the model parameter space to explain MiniBooNE, considering also potential contributions from oscillations due to an eV-scale sterile neutrino. We then derive robust constraints on the model using neutrino-electron elastic scattering data from MINERvA. We find that MINERvA rules out a large region of parameter space, but allowed solutions exist at the $2\sigma$ confidence level. A dedicated MINERvA analysis would likely be able to probe the entire region of preference of MiniBooNE in this model.Comment: 14 page

Conservationists’ perspectives on poverty: an empirical study

1. Biodiversity conservation interventions have long confronted challenges of human poverty. The ethical foundations of international conservation, including conservation’s relationship with poverty, are currently being interrogated in animated debates about the future of conservation. However, while some commentary exists, empirical analysis of conservation practitioner perspectives on poverty, and their ethical justification, has been lacking thus far. 2. We used Q methodology complemented by more detailed qualitative analysis to examine empirically perspectives on poverty and conservation within the conservation movement, and compare these empirical discourses to positions within the literature. We sampled conservation practitioners in western headquartered organisations, and in Bolivia, China, Nepal and Uganda, thereby giving indications of these perspectives in Latin America, Asia and Africa. 3. While there are some elements of consensus, for instance the principle that the poor should not shoulder the costs of conserving a global public good, the three discourses elicited diverge in a number of ways. Anthropocentrism and ecocentrism differentiate the perspectives, but beyond this, there are two distinct framings of poverty which conservation practitioners variously adhere to. 4. The first prioritises welfare, needs and sufficientarianism, and is more strongly associated with the China, Nepal and Uganda case studies. The second framing of poverty focuses much more on the need for ‘do no harm’ principles and safeguards, and follows an internationalised human rights-oriented discourse. 5. There are also important distinctions between discourses about whether poverty is characterised as a driver of degradation, or more emphasis is placed on overconsumption and affluence in perpetuating conservation threats. This dimension particularly illuminates shifts in thinking in the 30 or so years since the Brundtland report, and reflecting new global realities. 6. This analysis serves to update, parse and clarify differing perspectives on poverty within the conservation, and broader environmental movement, in order to illuminate consensual aspects between perspectives, and reveal where critical differences remain

Electronic structure and excitonic absorption in BaCuChF (Ch=S, Se, and Te)

Double excitonic absorption peaks are observed in textured BaCuSF and BaCuSeF thin films. The excitonic doublet separation increases with increasing fraction of heavy chalcogen in the thin-film solid solutions, in good agreement with the spin-orbit splitting of the valence bands calculated by density-functional theory. In BaCuSF and BaCuSeF, the excitons have large binding energies (95 and 65 meV, respectively) and can be observed at room temperature. A three-dimensional Wannier-Mott excitonic absorption model gives good agreement between the experimental and theoretical optical properties. Band gaps of BaCuSF and BaCuSeF calculated using the GW approximation agree with experiment. In BaCuTeF, transitions across the lowest direct energy gap and excitonic absorption are suppressed, extending its transparent range

A survey of training and practice patterns of massage therapists in two US states

BACKGROUND: Despite the growing popularity of therapeutic massage in the US, little is known about the training or practice characteristics of massage therapists. The objective of this study was to describe these characteristics. METHODS: As part of a study of random samples of complementary and alternative medicine (CAM) practitioners, we interviewed 226 massage therapists licensed in Connecticut and Washington state by telephone in 1998 and 1999 (85% of those contacted) and then asked a sample of them to record information on 20 consecutive visits to their practices (total of 2005 consecutive visits). RESULTS: Most massage therapists were women (85%), white (95%), and had completed some continuing education training (79% in Connecticut and 52% in Washington). They treated a limited number of conditions, most commonly musculoskeletal (59% and 63%) (especially back, neck, and shoulder problems), wellness care (20% and 19%), and psychological complaints (9% and 6%) (especially anxiety and depression). Practitioners commonly used one or more assessment techniques (67% and 74%) and gave a massage emphasizing Swedish (81% and 77%), deep tissue (63% and 65%), and trigger/pressure point techniques (52% and 46%). Self-care recommendations, including increasing water intake, body awareness, and specific forms of movement, were made as part of more than 80% of visits. Although most patients self-referred to massage, more than one-quarter were receiving concomitant care for the same problem from a physician. Massage therapists rarely communicated with these physicians. CONCLUSION: This study provides new information about licensed massage therapists that should be useful to physicians and other healthcare providers interested in learning about massage therapy in order to advise their patients about this popular CAM therapy

Evidence-based patient choice: a prostate cancer decision aid in plain language

BACKGROUND: Decision aids (DA) to assist patients in evaluating treatment options and sharing in decision making have proliferated in recent years. Most require high literacy and do not use plain language principles. We describe one of the first attempts to design a decision aid using principles from reading research and document design. The plain language DA prototype addressed treatment decisions for localized prostate cancer. Evaluation assessed impact on knowledge, decisions, and discussions with doctors in men newly diagnosed with prostate cancer. METHODS: Document development steps included preparing an evidence-based DA in standard medical parlance, iteratively translating it to emphasize shared decision making and plain language in three formats (booklet, Internet, and audio-tape). Scientific review of medical content was integrated with expert health literacy review of document structure and design. Formative evaluation methods included focus groups (n = 4) and survey of a new sample of men newly diagnosed with prostate cancer (n = 60), compared with historical controls (n = 184). RESULTS: A transparent description of the development process and design elements is reported. Formative evaluation among newly diagnosed prostate cancer patients found the DA to be clear and useful in reaching a decision. Newly diagnosed patients reported more discussions with doctors about treatment options, and showed increases in knowledge of side effects of radiation therapy. CONCLUSION: The plain language DA presenting medical evidence in text and numerical formats appears acceptable and useful in decision-making about localized prostate cancer treatment. Further testing should evaluate the impact of all three media on decisions made and quality of life in the survivorship period, especially among very low literacy men

Domain Organization of Long Signal Peptides of Single-Pass Integral Membrane Proteins Reveals Multiple Functional Capacity

Targeting signals direct proteins to their extra - or intracellular destination such as the plasma membrane or cellular organelles. Here we investigated the structure and function of exceptionally long signal peptides encompassing at least 40 amino acid residues. We discovered a two-domain organization (“NtraC model”) in many long signals from vertebrate precursor proteins. Accordingly, long signal peptides may contain an N-terminal domain (N-domain) and a C-terminal domain (C-domain) with different signal or targeting capabilities, separable by a presumably turn-rich transition area (tra). Individual domain functions were probed by cellular targeting experiments with fusion proteins containing parts of the long signal peptide of human membrane protein shrew-1 and secreted alkaline phosphatase as a reporter protein. As predicted, the N-domain of the fusion protein alone was shown to act as a mitochondrial targeting signal, whereas the C-domain alone functions as an export signal. Selective disruption of the transition area in the signal peptide impairs the export efficiency of the reporter protein. Altogether, the results of cellular targeting studies provide a proof-of-principle for our NtraC model and highlight the particular functional importance of the predicted transition area, which critically affects the rate of protein export. In conclusion, the NtraC approach enables the systematic detection and prediction of cryptic targeting signals present in one coherent sequence, and provides a structurally motivated basis for decoding the functional complexity of long protein targeting signals