Direct Detection of Giant Close-In Planets Around the Source Stars of Caustic-Crossing Microlensing Events

We propose a direct method to detect close-in giant planets orbiting stars in the Galactic bulge. This method uses caustic-crossing binary microlensing events discovered by survey teams monitoring the bulge to measure light from a planet orbiting the source star. When the planet crosses the caustic, it is more magnified than the source star; its light is magnified by two orders of magnitude for Jupiter size planets. If the planet is a giant close to the star, it may be bright enough to make a significant deviation in the light curve of the star. Detection of this deviation requires intensive monitoring of the microlensing light curve using a 10-meter class telescope for a few hours after the caustic. This is the only method yet proposed to directly detect close-in planets around stars outside the solar neighborhood.Comment: 4 pages, 2 figures. Submitted to ApJ Letter

Plant Immunity and Film Noir What Gumshoe Detectives Can Teach Us about Plant-Pathogen Interactions

AbstractPlant cells practice constant vigilance using resistance (R) proteins to monitor pathogenic processes. Three papers published recently in Cell and one in Science provide support for a model in which plant cells set up surveillance of signal transduction pathways, preparing to destroy the cell if any untoward fiddling with cellular physiology is detected. The demonstration of three separate examples of such a system suggests that it is broadly used and should provoke a reexamination of microbial pathogenesis in animal cells to look for similar mechanisms

Liver Transplantation to Provide Low-Density-Lipoprotein Receptors and Lower Plasma Cholesterol in a Child with Homozygous Familial Hypercholesterolemia

A six-year-old girl with severe hypercholesterolemia and atherosclerosis had two defective genes at the low-density-lipoprotein (LDL) receptor locus, as determined by biochemical studies of cultured fibroblasts. One gene, inherited from the mother, produced no LDL receptors; the other gene, inherited from the father, produced a receptor precursor that was not transported to the cell surface and was unable to bind LDL. The patient degraded intravenously administered 125I-LDL at an extremely low rate, indicating that her high plasma LDL-cholesterol level was caused by defective receptor-mediated removal of LDL from plasma. After transplantation of a liver and a heart from a normal donor, the patient's plasma LDL-cholesterol level declined by 81 per cent, from 988 to 184 mg per deciliter. The fractional catabolic rate for intravenously administered 125I-LDL, a measure of functional LDL receptors in vivo, increased by 2.5-fold. Thus, the transplanted liver, with its normal complement of LDL receptors, was able to remove LDL cholesterol from plasma at a nearly normal rate. We conclude that a genetically determined deficiency of LDL receptors can be largely reversed by liver transplantation. These data underscore the importance of hepatic LDL receptors in controlling the plasma level of LDL cholesterol in human beings. (N Engl J Med 1984; 311: 1658–64.). © 1984, Massachusetts Medical Society. All rights reserved

Angular Radii of Stars via Microlensing

We outline a method by which the angular radii of giant and main sequence stars in the Galactic bulge can be measured to a few percent accuracy. The method combines ground-based photometry of caustic-crossing bulge microlensing events, with a handful of precise astrometric measurements of the lensed star during the event, to measure the angular radius of the source, theta_*. Dense photometric coverage of one caustic crossing yields the crossing timescale dt. Less frequent coverage of the entire event yields the Einstein timescale t_E and the angle phi of source trajectory with respect to the caustic. The photometric light curve solution predicts the motion of the source centroid up to an orientation on the sky and overall scale. A few precise astrometric measurements therefore yield theta_E, the angular Einstein ring radius. Then the angular radius of the source is obtained by theta_*=theta_E(dt/t_E) sin(phi). We argue that theta_* should be measurable to a few percent accuracy for Galactic bulge giant stars using ground-based photometry from a network of small (1m-class) telescopes, combined with astrometric observations with a precision of ~10 microarcsec to measure theta_E. We find that a factor of ~50 times fewer photons are required to measure theta_E to a given precision for binary-lens events than single-lens events. Adopting parameters appropriate to the Space Interferometry Mission (SIM), ~7 min of SIM time is required to measure theta_E to ~5% accuracy for giant sources in the bulge. For main-sequence sources, theta_E can be measured to ~15% accuracy in ~1.4 hours. With 10 hrs of SIM time, it should be possible to measure theta_* to ~5% for \~80 giant stars, or to 15% for ~7 main sequence stars. A byproduct of such a campaign is a significant sample of precise binary-lens mass measurements.Comment: 13 pages, 3 figures. Revised version, minor changes, required SIM integration times revised upward by ~60%. Accepted to ApJ, to appear in the March 20, 2003 issue (v586

Gravitational Lensing by Power-Law Mass Distributions: A Fast and Exact Series Approach

We present an analytical formulation of gravitational lensing using familiar triaxial power-law mass distributions, where the 3-dimensional mass density is given by $\rho(X,Y,Z) = \rho_0 [1 + (\frac{X}{a})^2 + (\frac{Y}{b})^2 + (\frac{Z}{c})^2]^{-\nu/2}$. The deflection angle and magnification factor are obtained analytically as Fourier series. We give the exact expressions for the deflection angle and magnification factor. The formulae for the deflection angle and magnification factor given in this paper will be useful for numerical studies of observed lens systems. An application of our results to the Einstein Cross can be found in Chae, Turnshek, & Khersonsky (1998). Our series approach can be viewed as a user-friendly and efficient method to calculate lensing properties that is better than the more conventional approaches, e.g., numerical integrations, multipole expansions.Comment: 24 pages, 3 Postscript figures, ApJ in press (October 10th

A Cellular Basis for Wolbachia Recruitment to the Host Germline

Wolbachia are among the most widespread intracellular bacteria, carried by thousands of metazoan species. The success of Wolbachia is due to efficient vertical transmission by the host maternal germline. Some Wolbachia strains concentrate at the posterior of host oocytes, which promotes Wolbachia incorporation into posterior germ cells during embryogenesis. The molecular basis for this localization strategy is unknown. Here we report that the wMel Wolbachia strain relies upon a two-step mechanism for its posterior localization in oogenesis. The microtubule motor protein kinesin-1 transports wMel toward the oocyte posterior, then pole plasm mediates wMel anchorage to the posterior cortex. Trans-infection tests demonstrate that factors intrinsic to Wolbachia are responsible for directing posterior Wolbachia localization in oogenesis. These findings indicate that Wolbachia can direct the cellular machintery of host oocytes to promote germline-based bacterial transmission. This study also suggests parallels between Wolbachia localization mechanisms and those used by other intracellular pathogens

Reciprocal Analysis of Francisella novicida Infections of a Drosophila melanogaster Model Reveal Host-Pathogen Conflicts Mediated by Reactive Oxygen and imd-Regulated Innate Immune Response

The survival of a bacterial pathogen within a host depends upon its ability to outmaneuver the host immune response. Thus, mutant pathogens provide a useful tool for dissecting host-pathogen relationships, as the strategies the microbe has evolved to counteract immunity reveal a host's immune mechanisms. In this study, we examined the pathogen Francisella novicida and identified new bacterial virulence factors that interact with different parts of the Drosophila melanogaster innate immune system. We performed a genome-wide screen to identify F. novicida genes required for growth and survival within the fly and identified a set of 149 negatively selected mutants. Among these, we identified a class of genes including the transcription factor oxyR, and the DNA repair proteins uvrB, recB, and ruvC that help F. novicida resist oxidative stress. We determined that these bacterial genes are virulence factors that allow F. novicida to counteract the fly melanization immune response. We then performed a second in vivo screen to identify an additional subset of bacterial genes that interact specifically with the imd signaling pathway. Most of these mutants have decreased resistance to the antimicrobial peptide polymyxin B. Characterization of a mutation in the putative transglutaminase FTN_0869 produced a curious result that could not easily be explained using known Drosophila immune responses. By using an unbiased genetic screen, these studies provide a new view of the Drosophila immune response from the perspective of a pathogen. We show that two branches of the fly's immunity are important for fighting F. novicida infections in a model host: melanization and an imd-regulated immune response, and identify bacterial genes that specifically counteract these host responses. Our work suggests that there may be more to learn about the fly immune system, as not all of the phenotypes we observe can be readily explained by its interactions with known immune responses

Simulations and cosmological inference: A statistical model for power spectra means and covariances

We describe an approximate statistical model for the sample variance distribution of the non-linear matter power spectrum that can be calibrated from limited numbers of simulations. Our model retains the common assumption of a multivariate Normal distribution for the power spectrum band powers, but takes full account of the (parameter dependent) power spectrum covariance. The model is calibrated using an extension of the framework in Habib et al. (2007) to train Gaussian processes for the power spectrum mean and covariance given a set of simulation runs over a hypercube in parameter space. We demonstrate the performance of this machinery by estimating the parameters of a power-law model for the power spectrum. Within this framework, our calibrated sample variance distribution is robust to errors in the estimated covariance and shows rapid convergence of the posterior parameter constraints with the number of training simulations.Comment: 14 pages, 3 figures, matches final version published in PR

The Clustering of AGN in the Sloan Digital Sky Survey

We present the two--point correlation function (2PCF) of narrow-line active galactic nuclei (AGN) selected within the First Data Release of the Sloan Digital Sky Survey. Using a sample of 13605 AGN in the redshift range 0.055 < z < 0.2, we find that the AGN auto--correlation function is consistent with the observed galaxy auto--correlation function on scales 0.2h^{-1}Mpc to >100h^{-1}Mpc. The AGN hosts trace an intermediate population of galaxies and are not detected in either the bluest (youngest) disk--dominated galaxies or many of the reddest (oldest) galaxies. We show that the AGN 2PCF is dependent on the luminosity of the narrow [OIII] emission line (L_{[OIII]}), with low L_{[OIII]} AGN having a higher clustering amplitude than high L_{[OIII]} AGN. This is consistent with lower activity AGN residing in more massive galaxies than higher activity AGN, and L_{[OIII]} providing a good indicator of the fueling rate. Using a model relating halo mass to black hole mass in cosmological simulations, we show that AGN hosted by ~ 10^{12} M_{odot} dark matter halos have a 2PCF that matches that of the observed sample. This mass scale implies a mean black hole mass for the sample of M_{BH} ~ 10^8 M_{odot}.Comment: 5 pages, 4 figures. Accepted for publication in ApJ