Techniques and instrumentation for combinatorial and high-throughput polymer research: Recent developments

A review. Emerging from the field of biochem. and pharmaceutical research, combinatorial and high-throughput synthesis and screening methodologies are rapidly being adopted in polymer and materials research. Alternative solns. to cost intensive custom-made synthetic robot systems have become com. available and further accelerate this field of research not just in industry, but also in an academic environment. High-throughput anal., materials characterization, and testing (surface energy, hardness, wettability, crystallinity etc.) are key techniques and require suitable instrumentation. Here we present a short overview of recent developments of robotic synthesizers and anal. equipment extending the review from Jan. 200

From small organic entities to metallo-supramolecular polymers

Abstract onl

Instrumentation for combinatorial and high-throughput polymer research: a short overview

Starting in biochemistry and pharmaceutical chemistry, combinatorial methods, automated synthesis and high-throughput characterization are being further developed for organic synthesis and polymer research. The development is strongly driven by the achievements in biochemistry and pharmaceutical chemistry and the need to minimize the time-to-market for novel polymeric products. The success of high-throughput methodologies in polymer science is partially limited by the commercially available hardware (synthesizers, workstations, robots, online-characterization instruments, etc.) and software. A short overview of commercially available equipment for polymer research is provided in this Review

Linear terpyridine-ruthenium(II) poly(ethylene glycol) coordination polymers

In the present contribution, we synthesized linear coordination polymers based on oligo(ethylene glycol)s as well as poly(ethylene glycol)s and terpyridine ruthenium(II) complexes. The reaction conditions, e.g., solvent, concentration, were varied to obtain well-soluble, high molecular weight polymers. The resulting compounds were characterized by UV-vis and NMR spectroscopy. The viscosity of the materials was also investigated with and without salt addition. Finally, the polymers were characterized with DSC and AFM. AFM revealed a lamellar morphology

Automated parallel synthesis of metallo-supramolecular polymers

Establishing entire high-throughput experimentation workflows is a prerequisite for the success of combinatorial materials and polymer research. Here we present the automated parallel metal-induced polymn. of terpyridine-bisfunctionalized poly(ethylene oxide) using different metal salts. The conversion to linear coordination polymers was screened utilizing a fast UV/Vis plate reader and IR spectroscopy. The mol. wts. of the obtained polymers were estd. on the basis of viscosity measurements with respect to the used metal and counter ion

New 4'-functionalized 2,2':6',2''-terpyridines for applications in macromolecular chemistry and nanoscience

The well-known reaction of 4'-chloro-2,2':6',2''-terpyridine with alkoxide nucleophiles leads to 4'-functionalized 2,2':6',2''-terpyridines. This reaction allows the easy introduction of different functional groups onto the terpyridine at the 4'-position, i.e., opposite to the metal binding site, in one reaction step. Among the functionalized 2,2':6',2''-terpyridines reported here are amines (including chiral examples), carboxylic acids, simple alkoxy-chain terpyridines with different chain lengths, and a stilbene-functionalized terpyridine (I). Moreover, the synthesis of two important already known substances was significantly improved. One example of a sequential functionalization of an (aminopentoxy)terpyridine with a dithiolane functionality, yielding II, is also reported. For two of the alkoxy-chain-functionalized terpyridines, single-crystal x-ray crystallog. data were obtained. Finally, ordered monolayers of alkoxy-substituted terpyridines III (n = 11, 17) on highly ordered pyrolytic graphite were visualized using STM. [on SciFinder (R)

Overall survival in the OlympiA phase III trial of adjuvant olaparib in patients with germline pathogenic variants in BRCA1/2 and high-risk, early breast cancer

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