Surgical embolectomy for acute massive pulmonary embolism: state of the art

Massive pulmonary embolism (PE) is a severe condition that can potentially lead to death caused by right ventricular (RV) failure and the consequent cardiogenic shock. Despite the fact thrombolysis is often administrated to critical patients to increase pulmonary perfusion and to reduce RV afterload, surgical treatment represents another valid option in case of failure or contraindications to thrombolytic therapy. Correct risk stratification and multidisciplinary proactive teams are critical factors to dramatically decrease the mortality of this global health burden. In fact, the worldwide incidence of PE is 60–70 per 100,000, with a mortality ranging from 1% for small PE to 65% for massive PE. This review provides an overview of the diagnosis and management of this highly lethal pathology, with a focus on the surgical approaches at the state of the art

Cerebrovascular complications and infective endocarditis. impact of available evidence on clinical outcome

Infective endocarditis (IE) is a life-threatening disease. Its epidemiological profile has substantially changed in recent years although 1-year mortality is still high. Despite advances in medical therapy and surgical technique, there is still uncertainty on the best management and on the timing of surgical intervention. The objective of this review is to produce further insight intothe short- and long-term outcomes of patients with IE, with a focus on those presenting cerebrovascular complications

Sales impact of servicescape’s emotional and rational stimuli: a survey study

Environmental psychologists suggest that people feelings and emotions determine what they do and how they do it. According to the stimulus organism respons model (SOR), the environment creates a behavioral/emotional response in individuals that, in turn, induces approach or avoidance behaviors. We conducted survey in six stores, settled in six different Italian cities, of a Swedish-founded Dutch-based multinational group, that designs and sells ready-to-assemble furniture, kitchen appliances and home accessories. Firstly, we apply the SOR model to evaluate loyalty program participation impact on consumers receipts. Subsequently, we provide empirical evidence about the effects of an emotional-sensorial stimulus (i.e. the presence of the restaurant inside the store). Through both a non-parametric and parametric testing, we found that environmental stimuli have a positive effect in terms of sales

Sales impact of servicescape's rational stimuli: a natural experiment

Environmental psychologists suggest that people feelings and emotions determine what they do and how they do it. We used the stimulus organism respons model (SOR) as an inspiring theoretical basis for our empirical contribution. We conducted a natural field experiment in six stores, settled in six different Italian cities, of a Swedish-founded Dutch-based multinational group, that designs and sells ready-to-assemble furniture, kitchen appliances and home accessories. We provided empirical evidence about the effects of a rational-functional stimulus, i.e. the availability of a new tool for collecting items that is more comfortable and less cumbersome for consumers. Through both a non-parametric and parametric testing, we found a positive effect of the stimuli in terms of sales

Sales impact of servicescape's rational stimuli: a natural experiment

Environmental psychologists suggest that people feelings and emotions determine what they do and how they do it. We used the stimulus organism respons model (SOR) as an inspiring theoretical basis for our empirical contribution. We conducted a natural field experiment in six stores, settled in six different Italian cities, of a Swedish-founded Dutch-based multinational group, that designs and sells ready-to-assemble furniture, kitchen appliances and home accessories. We provided empirical evidence about the effects of a rational-functional stimulus, i.e. the availability of a new tool for collecting items that is more comfortable and less cumbersome for consumers. Through both a non-parametric and parametric testing, we found a positive effect of the stimuli in terms of sales

Sales impact of servicescape’s rational stimuli: a natural field experiment

Environmental psychologists suggest that people feelings and emotions determine what they do and how they do it. We used the stimulus organism respons model (SOR) as an inspiring theoretical basis for our empirical contribution. We conducted a natural field experiment in six stores, settled in six different Italian cities, of a Swedish-founded Dutch-based multinational group, that designs and sells ready-to-assemble furniture, kitchen appliances and home accessories. We provided empirical evidence about the effects of a rational-functional stimulus, i.e. the availability of a new tool for collecting items that is more comfortable and less cumbersome for consumers. Through both a non-parametric and parametric testing, we found a positive effect of the stimuli in terms of sales

Radioactivity concentrations and their radiological significance in sediments of the Tema Harbour (Greater Accra, Ghana)

Abstract Studies on environmental radioactivity in tropical Africa are scarce. Therefore, a baseline study of natural ( 238 U, 210 Pb, 226 Ra, 232 Th, 228 Ra, 228 Th, 40 K) and anthropogenic ( 137 Cs) radionuclides was carried out on Tema Harbour (Greater Accra, Ghana) surface sediments and on their radiological significance. Grab surface sediment samples were collected from 21 stations within the Tema Harbour and their radioactivity concentrations measured by gamma spectrometry. The mean sediment radioactivity concentrations (Bq kg −1 dw) were 34 for 238 U, 210 for 210 Pb, 14 for 226 Ra, 30 for 232 Th, 29 for 228 Ra, 31 for 228 Th, 320 for 40 K, and 1.5 for 137 Cs. Large 238 U/ 226 Ra disequilibria were observed in the harbour sediments and a complex dynamics of several mixed sources of sediments within the Tema Harbour can be inferred from the spatial variations in the radioactivity concentrations. The estimated total absorbed dose rate in air ( D ), radium equivalent activity (Ra eq ), external hazard index ( H ex ), annual gonadal dose equivalent (AGDE) and annual effective dose equivalent (AEDE) indicated no significant radiological risks from the sediment radioactivity concentrations. Application of the Environmental Risk from Ionising Contaminants Assessment and Management tool (ERICA) confirmed that the potential dose rates to biota from the sediment radioactivity concentrations are unlikely to pose appreciable ecological risks. The radioactivity levels are compared with levels reported in sediments from other coastal areas of the world

Settling fluxes and sediment accumulation rates by the combined use of sediment traps and sediment cores in Tema Harbour (Ghana)

Settling fluxes and sediment accumulation rates in coastal Tema Harbour (Ghana) were investigated by the combined analyses of results in sediment traps and sediment cores. Sediment traps were deployed at 5 stations within the Tema Harbour at two sampling depths and were retrieved every two weeks till the end of 12 weeks to estimate the Settling Fluxes (SFs). Four sediment cores from the harbour were analysed for their radioactivity (7Be, 234Th, 210Pb, 212Pb, 226Ra, 40K and 137Cs) profiles to quantify Sediment Accumulation Rates (SARs). The sediment cores exhibited variable bulk density profiles, indicating highly dynamic and non-steady sedimentation conditions. 7Be-derived gross-estimates of very recent SARs using the constant flux-constant sedimentation (CF-CS) model were in the range of 2.5–9.0 g·cm− 2·y− 1. These values were much lower than the estimated average SFs (15.2–53.8 g·cm− 2·y− 1), indicating sediment resuspension plays an important role. On a decadal time scale, conventional 210Pb sediment dating models did not allow any estimation of SARs in the Tema Harbour. Thus, the 210Pb-based TERESA model was applied to depict a reliable scenario for sedimentation with time-averaged SARs in the range of 1.4–3.0 g·cm− 2·y− 1 and fluxes of matter contributed by the marine inflow and local sources. Sediment accretion rates of 1.7–3 cm·y− 1 were also inferred, which may pose a moderate problem of sustainability for the Tema Harbour. This study reveals how the geochemical behaviour of different radionuclides with Gamma spectrometry in the marine environment can be used to obtain reliable information on the complex dynamics of Suspended Particulate Matter (SPM), even in a very disturbed and anthropic environment as a coastal harbour area where (1) conventional 210Pb-based dating methods fail and (2) the use of sediment traps and 234Th and 7Be profiles in sediment cores show serious constraints.University of Ghana UGFD/7/2012-2013/00

Rapporto tecnico sulle attività di campionamento della “Campagna Oceanografica CISAS_2” Crotone 07-12 dicembre 2017

Le attività di campionamento ed acquisizione dati svolte durante la campagna CISAS_2 si inseriscono in seno al progetto “Centro internazionale di studi avanzati su ambiente ed impatti su ecosistema e salute umana (CISAS)” del CNR. L’obiettivo principale del progetto CISAS è la comprensione dei processi e dei meccanismi di trasferimento di alcuni contaminanti convenzionali (metalli pesanti, POPs, radionuclidi, ecc.) e di alcuni contaminanti emergenti (PDBE, composti farmaceutici di nuova generazione, ecc.) dall’ambiente inteso come l’insieme di atmosfera-suoli-acque sotterranee-matrici marine (acque e sedimento) all’ecosistema e all’uomo. Le aree di indagine del progetto sono i Siti di Interesse Nazionale (SIN) di Priolo, Milazzo-Pace del Mela e Crotone che, per specificità e modalità di impatto antropogenico sull’ambiente, l’ecosistema e la salute umana, coprono un ampio spettro di tipologie di interesse. La campagna oceanografica CISAS_ 2 è stata dedicata alla caratterizzazione ambientale del SIN di Crotone, nonché all’identificazione delle sorgenti dei contaminanti la cui distribuzione si ritiene di interesse (per i valori di concentrazione riscontrati nelle diverse matrici ambientali e per livello di tossicità associata agli effetti degli stessi sulla salute dell’ecosistema e dell’uomo) e i pathways di deposizione nelle aree di interesse

Remodeled eX vivo muscle engineered tissue improves heart function after chronic myocardial ischemia

: The adult heart displays poor reparative capacities after injury. Cell transplantation and tissue engineering approaches have emerged as possible therapeutic options. Several stem cell populations have been largely used to treat the infarcted myocardium. Nevertheless, transplanted cells displayed limited ability to establish functional connections with the host cardiomyocytes. In this study, we provide a new experimental tool, named 3D eX vivo muscle engineered tissue (X-MET), to define the contribution of mechanical stimuli in triggering functional remodeling and to rescue cardiac ischemia. We revealed that mechanical stimuli trigger a functional remodeling of the 3D skeletal muscle system toward a cardiac muscle-like structure. This was supported by molecular and functional analyses, demonstrating that remodeled X-MET expresses relevant markers of functional cardiomyocytes, compared to unstimulated and to 2D- skeletal muscle culture system. Interestingly, transplanted remodeled X-MET preserved heart function in a murine model of chronic myocardial ischemia and increased survival of transplanted injured mice. X-MET implantation resulted in repression of pro-inflammatory cytokines, induction of anti-inflammatory cytokines, and reduction in collagen deposition. Altogether, our findings indicate that biomechanical stimulation induced a cardiac functional remodeling of X-MET, which showed promising seminal results as a therapeutic product for the development of novel strategies for regenerative medicine