2 research outputs found
Oral health related quality of life in patients with diffuse connective tissue diseases
Introduction. Health-related quality of life (H-RQoL) is an individual's perception of their position in life in the
context of the culture and value systems in which they live, regarding both positive and negative elements in relation
to their goals, expectations, standards and concerns. within five dimensions: physical and material, social and
emotional wellbeing, development and activity.
Aim of study. Oral health-related quality of life (OHRQOL) is “a set of multidisciplinary elements that reflects
people's comfort when they eat, sleep, and engage in social interaction, self-esteem, and oral health satisfaction”.
Moreover, OHRQOL is associated with functional, psychological, and social factors, the sensation of pain or
discomfort.The Aim of study was to assess the affinity of oral health-related quality of life with health-related quality
of life and their interaction in patients with diffuse connective tissue disease.
Methods and materials. A descriptive study was conducted selecting patients in a group of 21 subjects with diffuse
connective tissue diseases. The quality of life was quantified by SF-8 (Short Form) in 8 domains and OHRQOL - in
7 domains with 14 questions. Although, were evaluated pain and fatigability by VAS, PGA and MDGA
Results. Data analyzed reveal the predominance of women (85.71%) in the study group, with a female to male ratio
of 7: 1. The mean ± SD quality of life SF-8 physical and mental was 41,77 ± 15.76 and 56,90± 11.61 points,
respectivily with wide variational interval - from 9.2 to 74.6 points. The pain by VAS was 62.50 ± 5.72 mm with
wide variational interval - from 43 to 80, fatigability 60,5 ± 6,23 (range 40-74), PGA 53,0± 11,72 (range 30-66),
MDGA – 51,33± 5.76 (range 40-70). The next scoring OHRQOL intems were social functional limitation (1p),
physical pain (3p), psychological discomfort (5,14 p) and physical disability (2,23p), psychological disability (1,57p),
social disability (2,75p) and disability (4p). The strongest correlation of domain of oral HR QoL was found with SF-
8 physical status (r=0.64), followed by VAS fatigability (r=0.59) and MDGA (r=0.57). Within OHRQOL the data
showed that psychological discomfort closely correlated with psychological disability (r=0.56) and life
dissatisfaction correlated with social disability (r=0.42). Physical state correlation data with OHRQOL domains have
been closely correlated with social disability and functional incapacity (r=0.53). At the same time SF-8 mental status
has been correlated with psychological discomfort (r=0.43), followed by psychological disability (r=0.39).
Correlation of OHRQOL questionnaire indices found close correlation between psychological discomfort and social
disability.
Conclusion. Oral health-related quality of life and health-related quality of life assessment should be seen as
complementary and can be used together to improve mutual understanding of patients' QOL status as well as
partnership in disease management. At the same time, PGA and MDGA can be useful tools in assessing the activity
of systemic diseases, as they have a low risk of misclassifying an inactive disease and can capture the health aspects
of patients that adversely affect their well-being and treatment outcomes
Five diseases make a mixed connective tissue disease
Introduction. Mixed connective tissue disease (MCTD) is a rare autoimmune disorder that has 5 other
connective tissue diseases: systemic lupus erythematosus, systemic sclerosis, polymyositis,
dermatomyositis and rheumatoid arthritis. A sixth - Sjögren's syndrome, is commonly associated with each
of these diseases. Current clinical records often note that one autoimmune rheumatic disease seems to
evolve into another over the course of several years and this occurs in approximately 25 percent of patients.
Case presentation. We report a case of a female patient A, 43 y.o., she is complains started with the
insidious onset manifested by inflammatory joint syndrome of bilateral radiocarpal, talocrural, synovitis of
knee joints and decreased muscle strength, morning stiffness > 30 minutes with relief from exercise and
movement, swelling of the proximal and distal metacarpophalangeal joints, skin hyperpigmentation on the
trunk, heart palpitations, positive Shirmer test, weight loss 10 kg, severe fatigue by VAS - 82/100 mm.
Discussion. Radiography features showed erosions and deforming like in rheumatoid arthritis. Echo
showed moderate pulmonary hypertension, mitral and tricuspid valve regurgitation stage II. Serological
examination showed (anti-CCP, ScL-70, dsDNA -negative, C3, C4- norma, rheumatoid factor, anti-RNP
are positive. A diagnosis of MCTD was made, based on the criteria of Alarcón-Segovia and Villareal;
patients met both clinical and serological criteria, with Anti-RNP values in high titers.
Conclusion. MCTD is a well-defined entity using well-defined criteria. The complications of the disorder
have already been described, most deaths from MCTD are due to heart failure caused by pulmonary arterial
hypertension and ILD because it is important to note that both comorbidities worsen patient prognosis. The
medications and dosage will depend on the severity of activity and damage disease