PROGRESSION IN AIDS AMONG ITALIAN HIV-SEROPOSITIVE HAEMOPHILIACS

To investigate the interval between HIV-1 infection and the development of clinical AIDS among Italian patients with congenital coagulation disorders, a national cohort study was undertaken in 1988. Information was collected both retrospectively and prospectively on 499 HIV-1-positive patients enrolled in an ongoing national registry of patients with congenital coagulation disorders. Two methods were used to estimate each patient's seroconversion date: the mid-point between the last negative (either known or estimated) and the first positive test, and the median under a Weibull distribution, which was assumed to fit seroconversion data. The two methods of estimating the seroconversion time yielded similar results. The actuarial incidence of AIDS was estimated using the Kaplan-Meier survival analysis at 12.8% (95% confidence interval = 9.7-15.9) over 7 years for Italian haemophiliacs. Progression appears to be slow in the first 5 years after the infection, and to rise steadily thereafter. A strong association between faster progression and older age at seroconversion was found. Zidovudine-treated individuals seem to have a slower progression than untreated individuals, after controlling for CD4, but there was no association between progression and type and severity of the congenital disorder

Medici a Verona: Indagine sui fattori di benessere/malessere dei professionisti veronesi

E' il primo esito di una ricerca sviluppata nel 2014 nei confronti dei medici appartenenti all'albo dell'ordine dei medici della provincia di Verona. Si analizzano prevalentemente le condizioni segnalate di benessere o malessere in base ai quesiti proposti dal questionario. Hanno risposto pi\uf9 di un migliaio di medici rendendo particolarmente interessanti le indicazioni ricevute