Silicon resonant microcantilevers for absolute pressure measurement

This work is focused on the developing of silicon resonant microcantilevers for the measurement of the absolute pressure. The microcantilevers have been fabricated with a two-mask bulk micromachining process. The variation in resonance response of microcantilevers was investigated as a function of pressure 10−1-105 Pa, both in terms of resonance frequency and quality factor. A theoretical description of the resonating microstructure is given according to different molecular and viscous regimes. Also a brief discussion on the different quality factors contributions is presented. Theoretical and experimental data show a very satisfying agreement. The microstructure behavior demonstrates a certain sensitivity over a six decade range and the potential evolution of an absolute pressure sensor working in the same rang

Application of an ultra-wide band sensor-free wireless network for ground monitoring

Ground displacement monitoring is one of the most important aspects of early warning systems and risk management strategies when addressing phenomena such as landslides or subsidence. Several types of instrumentation already exist, but those able to provide real-time warnings on multiple time series are typically based on expensive technology, highlighting the need to develop a low-cost, easy to install system suitable for emergency monitoring. Therefore, a wireless network based on ultra-wideband impulse radiofrequency technology has been realized. The novelty of this network consists of its ability to measure the distance between nodes using the same signals used for transmission without the need for an actual measurement sensor. The system was tested by monitoring a mudflow in Central Italy and revealed its suitability as an early warning tool. More research on the integration of future low-cost hardware and and eventual industrialization would provide further improvement to this promising technology.Published1-142V. Struttura e sistema di alimentazione dei vulcani4V. Processi pre-eruttiviJCR Journa

Seasonal variation of anti-PD-1 outcome in melanoma—Results from a Dutch patient cohort

Despite the improved survival rates of patients with advanced stage melanoma since the introduction of ICIs, many patients do not have (long-term) benefit from these treatments. There is evidence that the exposome, an accumulation of host-extrinsic factors including environmental influences, could impact ICI response. Recently, a survival benefit was observed in patients with BRAF wild-type melanoma living in Denmark who initiated immunotherapy in summer as compared to winter. As the Netherlands lies in close geographical proximity to Denmark and has comparable seasonal differences, a Dutch validation cohort was established using data from our nationwide melanoma registry. In this study, we did not observe a similar seasonal difference in overall survival and are therefore unable to confirm the Danish findings. Validation of either the Dutch or Danish findings in (combined) patient cohorts from other countries would be necessary to determine whether this host-extrinsic factor influences the response to ICI-treatment.</p

Seasonal variation of anti-PD-1 outcome in melanoma—Results from a Dutch patient cohort

Despite the improved survival rates of patients with advanced stage melanoma since the introduction of ICIs, many patients do not have (long-term) benefit from these treatments. There is evidence that the exposome, an accumulation of host-extrinsic factors including environmental influences, could impact ICI response. Recently, a survival benefit was observed in patients with BRAF wild-type melanoma living in Denmark who initiated immunotherapy in summer as compared to winter. As the Netherlands lies in close geographical proximity to Denmark and has comparable seasonal differences, a Dutch validation cohort was established using data from our nationwide melanoma registry. In this study, we did not observe a similar seasonal difference in overall survival and are therefore unable to confirm the Danish findings. Validation of either the Dutch or Danish findings in (combined) patient cohorts from other countries would be necessary to determine whether this host-extrinsic factor influences the response to ICI-treatment. Analysis and support of clinical decision makin

Seasonal variation of anti-PD-1 outcome in melanoma-Results from a Dutch patient cohort

Despite the improved survival rates of patients with advanced stage melanoma since the introduction of ICIs, many patients do not have (long-term) benefit from these treatments. There is evidence that the exposome, an accumulation of host-extrinsic factors including environmental influences, could impact ICI response. Recently, a survival benefit was observed in patients with BRAF wild-type melanoma living in Denmark who initiated immunotherapy in summer as compared to winter. As the Netherlands lies in close geographical proximity to Denmark and has comparable seasonal differences, a Dutch validation cohort was established using data from our nationwide melanoma registry. In this study, we did not observe a similar seasonal difference in overall survival and are therefore unable to confirm the Danish findings. Validation of either the Dutch or Danish findings in (combined) patient cohorts from other countries would be necessary to determine whether this host-extrinsic factor influences the response to ICI-treatment

Process Innovation for Cultural Heritage digitalization and valorization

This paper aims to show a case of process, based on the design and development of an ICT platform named “Di “Di CeT Archeo”, based on on the Rudiae Archaeological Site located in Lecce (Italy). The main purpose of the study is to bring iprocess innovation within the Cultural Heritage Lifecycle , focusing on cultural resources with a significant economic value, as for example in terms of tourist spendingourist. The methodological approach includes the modelling of processes involved in the data collection, from the phase of survey to the valorisation, to provide a new method for the exploitation of the Cultural Herita, considered as a complex, heterogeneous and still fragmented sector. The main innovation of the methodology consists in the application of techniques widely applied in the the manufacturing and business domains, on the archaeological domain