Innovative sales, R&D, and total innovation expenditures: panel evidence on their dynamics.

Dans cette étude nous estimons une fonction de production de l'innovation dynamique sur base des données de panel de cinq vagues d'enquêtes d'innovation communautaires (CIS) aux Pays-Bas couvrant la période 1994 à 2004. Nous estimons par maximum de vraisemblance un modèle tobit bivarié avec une double sélection et prise en compte des effets individuels. Nous trouvons une persistence dans l'innovation tant au niveau de l'intrant que de l'extrant et des effets de retard croisés entre les deux. Les retards perdurent au-delà de 4 ans dans le secteur high-tech. Les effets individuels et les effets particuliers aux industries sont également significatifs.This paper studies the dynamic relationship between input and output of innovation in Dutch manufacturing using an unbalanced panel of enterprise data from five waves of the Community Innovation Survey during 1994-2004. We estimate by maximum likelihood a dynamic panel data bivariate tobit with double-index sample selection accounting for individual effects. We find persistence of innovation input and innovation output, a lag effect of the former on the latter and a feedback effect of the latter on the former. The lag effect remains significant in the high-tech sector even after four years. Firm and industry effects are also important

Innovation in enterprise clusters: evidence from Dutch manufacturing

Cette étude aborde et illustre un problème d'agrégation qui peut se poser dans les études d'innovation. Les données utilisées sont celles de la troisième enquête innovation aux Pays-Bas, qui sont jumelées aux statistiques de la production et aux données financières des sociétés. Nous comparons les résultats de l'estimation d'une équation d'innovation, obtenus tour à tour à partir de données au niveau des entreprises (bedrijfseenheid), des grappes d'entreprises domestiques (onderneming), et des grappes d'entreprises ayant des filiales à l'étranger ou contenant des filiales de firmes étrangères installées aux Pays-Bas.This paper explores the aggregation problem and illustrates its relevance using data for the Netherlands from the third Community Innovation Survey (CIS3), and production and financial statistics. It compares the results of an innovation output equation that was estimated using data on enterprises (bedrijfseenheid), domestic enterprise clusters (onderneming), and those enterprise clusters with foreign inward or outward investments

The P4G-Getting to Zero Coalition Partnership: Finding and supporting opportunities to decarbonise shipping in Indonesia, Mexico and South Africa

The International Maritime Organization has committed to reducing greenhouse gases emissions from international shipping by at least 50% by 2050 compared to 2008 levels. To reach that goal, a shift towards new low- and zero-carbon fuels -such as hydrogen and ammonia- is urgently needed, along with the deployment of safe and reliable zero-emission vessels, technologies and infrastructure. With shipping being a potential significant demand driver for these new fuels, it can act as a trigger and catalyst for the broader energy transition, benefiting other sectors of the economy. The P4G-Getting to Zero (GtZ) Coalition Partnership is a two-year project that focuses on shipping decarbonisation business and development opportunities in Indonesia, Mexico and South Africa. To the project’s core is the priority of bringing forward the national voices, priorities and policies around climate change, energy transition, job generation and air pollution. To that end, the P4G-GtZ team detected and engaged with key national and international stakeholders that can provide the current countries’ landscape, diagnostic and synergies around shipping opportunities. Apart from generating a networking space for the different key stakeholders, the project delivered detailed shipping activity maps coupled with energy studies that throw light at which low/zero-carbon fuel offers better feasibility to decarbonise shipping taking into account policy, job generation and international competition. The poster introduces the P4G-GtZ Coalition Partnership and the progress done so far while highlighting key findings around shipping decarbonisation, hydrogen-based fuels potential and energy transitions

Cervical determinants of anal HPV infection and high-grade anal lesions in women: a collaborative pooled analysis

Cervical cancer screening might contribute to the prevention of anal cancer in women. We aimed to investigate if routine cervical cancer screening results-namely high-risk human papillomavirus (HPV) infection and cytohistopathology-predict anal HPV16 infection, anal high-grade squamous intraepithelial lesions (HSIL) and, hence, anal cancer.International Agency for Research on Cance

Risk Factors for and Clinical Outcome of Congenital Cytomegalovirus Infection in a Peri-Urban West-African Birth Cohort

BACKGROUND: Congenital cytomegalovirus (CMV) infection is the most prevalent congenital infection worldwide. Epidemiology and clinical outcomes are known to vary with socio-economic background, but few data are available from developing countries, where the overall burden of infectious diseases is frequently high. METHODOLOGY/PRINCIPAL FINDINGS: As part of an ongoing birth cohort study in The Gambia among term infants, urine samples were collected at birth and tested by PCR for the presence of CMV DNA. Risk factors for transmission and clinical outcome were assessed, including placental malaria infection. Babies were followed up at home monthly for morbidity and anthropometry, and at one year of age a clinical evaluation was performed. The prevalence of congenital CMV infection was 5.4% (40/741). A higher prevalence of hepatomegaly was the only significant clinical difference at birth. Congenitally infected children were more often first born babies (adjusted odds ratio (OR) 5.3, 95% confidence interval (CI) 2.0-13.7), more frequently born in crowded compounds (adjusted OR 2.9, 95%CI 1.0-8.3) and active placental malaria was more prevalent (adjusted OR 2.9, 95%CI 1.0-8.4). These associations were corrected for maternal age, bed net use and season of birth. During the first year of follow up, mothers of congenitally infected children reported more health complaints for their child. CONCLUSIONS/SIGNIFICANCE: In this study, the prevalence of congenital CMV among healthy neonates was much higher than previously reported in industrialised countries, and was associated with active placental malaria infection. There were no obvious clinical implications during the first year of life. The effect of early life CMV on the developing infant in the Gambia could be mitigated by environmental factors, such as the high burden of other infections.Journal ArticleResearch Support, Non-U.S. Gov'tinfo:eu-repo/semantics/publishe

Single-cell multi-omics analysis of the immune response in COVID-19

Peer reviewedPublisher PD

Cervical human papillomavirus infection and squamous intraepithelial lesions in rural Gambia, West Africa: viral sequence analysis and epidemiology

The development of effective strategies against cervical cancer in Africa requires accurate type specific data on human papillomavirus (HPV) prevalence, including determination of DNA sequences in order to maximise local vaccine efficacy. We have investigated cervical HPV infection and squamous intraepithelial lesions (SIL) in an unselected cohort of 1061 women in a rural Gambian community. Squamous intraepithelial lesions was diagnosed using cytology and histology, HPV was typed by PCR-ELISA of DNA extracts, which were also DNA sequenced. The prevalence of cervical HPV infection was 13% and SIL were observed in 7% of subjects. Human papillomavirus-16 was most prevalent and most strongly associated with SIL. Also common were HPV-18, -33, -58 and, notably, -35. Human papillomavirus DNA sequencing revealed HPV-16 samples to be exclusively African type 1 (Af1). Subjects of the Wolof ethnic group had a lower prevalence of HPV infection while subjects aged 25–44 years had a higher prevalence of cervical precancer than older or younger subjects. This first report of HPV prevalence in an unselected, unscreened rural population confirms high rates of SIL and HPV infection in West Africa. This study has implications for the vaccination of Gambian and other African populations in the prevention of cervical cancer

Do people living with HIV experience greater age advancement than their HIV-negative counterparts?

Objectives: Despite successful antiretroviral therapy, people living with HIV (PLWH) may show signs of premature/accentuated aging. We compared established biomarkers of aging in PLWH, appropriately chosen HIV-negative individuals, and blood donors, and explored factors associated with biological age advancement. Design: Cross-sectional analysis of 134 PLWH on suppressive antiretroviral therapy, 79 lifestyle-comparable HIV-negative controls aged 45 years or older from the Co-mor- Bidity in Relation to AIDS (COBRA) cohort, and 35 age-matched blood donors. Methods: Biological age was estimated using a validated algorithm based on 10 biomarkers. Associations between ‘age advancement’ (biological minus chronological age) and HIV status/parameters, lifestyle, cytomegalovirus (CMV), hepatitis B (HBV) and hepatitis C virus (HCV) infections were investigated using linear regression. Results: The average (95% CI) age advancement was greater in both HIV-positive [13.2 (11.6–14.9) years] and HIV-negative [5.5 (3.8–7.2) years] COBRA participants compared with blood donors [7.0 (4.1 to 9.9) years, both P’s<0.001)], but also in HIV-positive compared with HIV-negative participants (P<0.001). Chronic HBV, higher anti-CMV IgG titer and CD8þ T-cell count were each associated with increased age advancement, independently of HIV-status/group. Among HIV-positive participants, age advancement was increased by 3.5 (0.1–6.8) years among those with nadir CD4þ T-cell count less than 200 cells/ml and by 0.1 (0.06–0.2) years for each additional month of exposure to saquinavir