Пространство эстетизации повседневных жизненных практик:динамика, противоречия, социальный контекст

Научно-квалификационная работа посвящена актуальной проблеме, обусловленной дискуссионным характером социокультурных изменений, вызванных "пространственным поворотом", эстетизацией повседневности и обществом переживаний. Эстетизация, затрагивающая все сферы человеческой деятельности, и дигитализация, меняющая способ коммуникации современного индивида и формирующая новый "фокус" восприятия мира, определяют современное "общество переживаний" и "экономику впечатлений", трансформируют характер и цель социального взаимодействия, отношения человека с миром, ведут к смещению ценностных ориентиров. В работе дается характеристика концепций "общества переживаний", "экономики впечатлений", "эстетизация повседневности"; проанализирована эволюция этих идей.The scientific and qualification work is devoted to the actual problem, caused by the controversial nature of the sociocultural changes caused by the "spatial turn", aesthetisation of everyday life and the experience society. Aesthetization, affecting all spheres of human activity, and digitalization, changing the way of communication of a modern individual and forming a new "focus" of the world perception determine the modern "experience society" and " experience economy", transform the nature and purpose of social interaction, human relations with the world, lead to the displacement of value points. The work describes the concepts of the "experience society", " experience economy", " aesthetisation of everyday life "; The evolution of these ideas is analyzed

Use Your Strategic Entrepreneurs to Build Your Strategic Partnerships

Internationalisation through strategic partnerships is a goal for many higher education institutions and their upper-level management teams. Yet for institutional objectives to truly flourish, they should get the most out of the various skills that different actors bring to be table. This piece explores the interesting role that can be played by resourceful academic staff in materialising institutional, and individual, aims

Metformin as a Therapeutic Target in Endometrial Cancers.

Endometrial cancer is the most common gynecologic malignancy in developed countries. Its increasing incidence is thought to be related in part to the rise of metabolic syndrome, which has been shown to be a risk factor for the development of hyperestrogenic and hyperinsulinemic states. This has consequently lead to an increase in other hormone-responsive cancers as well e.g., breast and ovarian cancer. The correlation between obesity, hyperglycemia, and endometrial cancer has highlighted the important role of metabolism in cancer establishment and persistence. Tumor-mediated reprogramming of the microenvironment and macroenvironment can range from induction of cytokines and growth factors to stimulation of surrounding stromal cells to produce energy-rich catabolites, fueling the growth, and survival of cancer cells. Such mechanisms raise the prospect of the metabolic microenvironment itself as a viable target for treatment of malignancies. Metformin is a biguanide drug that is a first-line treatment for type 2 diabetes that has beneficial effects on various markers of the metabolic syndrome. Many studies suggest that metformin shows potential as an adjuvant treatment for uterine and other cancers. Here, we review the evidence for metformin as a treatment for cancers of the endometrium. We discuss the available clinical data and the molecular mechanisms by which it may exert its effects, with a focus on how it may alter the tumor microenvironment. The pleiotropic effects of metformin on cellular energy production and usage as well as intercellular and hormone-based interactions make it a promising candidate for reprogramming of the cancer ecosystem. This, along with other treatments aimed at targeting tumor metabolic pathways, may lead to novel treatment strategies for endometrial cancer

Influence of bevacizumab on vaginal cuff evisceration eight months after ovarian cancer cytoreduction surgery: A case report.

•44 year old woman treated with bevacizumab for metastatic epithelial ovarian cancer•The patient experienced vaginal cuff dehiscence and evisceration at 8 months post-operatively.•Metastasis at the surgical site and chronic inflammation implicated

Получение и свойства керамических материалов на основе системы Al[2]O[3]-MgO

It is known that aluminum oxide is the most generally used ceramic material applied as structural, functional and biomaterial. Meanwhile, it is used not only in a high state and but also in a highporous state. To obtain the required functional properties it is alloyed by various oxides such as FeO, SiO[2], Y[2]O[3], MgO and others. What most interested us is the magnasium oxide (MgO), as it is well known that the MgO presence in the ceramics materials causes biological processes activation at the boundary "implant - bone". However, the introduction of MgO into sintered mixture may change technological regimes of ceramics production and as a result to the structure and properties of the material can be changed as well. The aim of this work is to study the influence of the concentration of the injected mixture into the sintered MgO in the amount up to 10 wt. %. onto porosity, shrinkage characteristics of the microstructure and mechanical properties of the sintered material

Experiences of hearing aid use among patients with mild cognitive impairment and Alzheimer’s disease dementia: A qualitative study

Objectives: Hearing aid usage supports communication and independence; however, many do not use their hearing aids. This study explored the experiences of hearing aid use in adults with mild cognitive impairment or Alzheimer's disease. Methods: Participants completed semi-structured interviews which were analysed using thematic analysis. Ten people (six males, age range 75-86 years old) with mild cognitive impairment or Alzheimer's disease who had been fitted with hearing aids were recruited to the study. Results: We identified four major themes: (1) memory and other cognitive barriers to using hearing aids, (2) practical aspects of hearing aids, (3) benefits of hearing aids, and (4) ambivalence towards hearing aids. Conclusions: Participants perceived a significant impact of cognitive impairment on the experience of using hearing aids. This population may benefit from targeted strategies to support use of hearing aids. The findings from this study can inform future research to optimise use of hearing aids in this population