1,027 research outputs found
ΠΡΠΎΡΡΡΠ°Π½ΡΡΠ²ΠΎ ΡΡΡΠ΅ΡΠΈΠ·Π°ΡΠΈΠΈ ΠΏΠΎΠ²ΡΠ΅Π΄Π½Π΅Π²Π½ΡΡ ΠΆΠΈΠ·Π½Π΅Π½Π½ΡΡ ΠΏΡΠ°ΠΊΡΠΈΠΊ:Π΄ΠΈΠ½Π°ΠΌΠΈΠΊΠ°, ΠΏΡΠΎΡΠΈΠ²ΠΎΡΠ΅ΡΠΈΡ, ΡΠΎΡΠΈΠ°Π»ΡΠ½ΡΠΉ ΠΊΠΎΠ½ΡΠ΅ΠΊΡΡ
ΠΠ°ΡΡΠ½ΠΎ-ΠΊΠ²Π°Π»ΠΈΡΠΈΠΊΠ°ΡΠΈΠΎΠ½Π½Π°Ρ ΡΠ°Π±ΠΎΡΠ° ΠΏΠΎΡΠ²ΡΡΠ΅Π½Π° Π°ΠΊΡΡΠ°Π»ΡΠ½ΠΎΠΉ ΠΏΡΠΎΠ±Π»Π΅ΠΌΠ΅, ΠΎΠ±ΡΡΠ»ΠΎΠ²Π»Π΅Π½Π½ΠΎΠΉ Π΄ΠΈΡΠΊΡΡΡΠΈΠΎΠ½Π½ΡΠΌ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΎΠΌ ΡΠΎΡΠΈΠΎΠΊΡΠ»ΡΡΡΡΠ½ΡΡ
ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠΉ, Π²ΡΠ·Π²Π°Π½Π½ΡΡ
"ΠΏΡΠΎΡΡΡΠ°Π½ΡΡΠ²Π΅Π½Π½ΡΠΌ ΠΏΠΎΠ²ΠΎΡΠΎΡΠΎΠΌ", ΡΡΡΠ΅ΡΠΈΠ·Π°ΡΠΈΠ΅ΠΉ ΠΏΠΎΠ²ΡΠ΅Π΄Π½Π΅Π²Π½ΠΎΡΡΠΈ ΠΈ ΠΎΠ±ΡΠ΅ΡΡΠ²ΠΎΠΌ ΠΏΠ΅ΡΠ΅ΠΆΠΈΠ²Π°Π½ΠΈΠΉ. ΠΡΡΠ΅ΡΠΈΠ·Π°ΡΠΈΡ, Π·Π°ΡΡΠ°Π³ΠΈΠ²Π°ΡΡΠ°Ρ Π²ΡΠ΅ ΡΡΠ΅ΡΡ ΡΠ΅Π»ΠΎΠ²Π΅ΡΠ΅ΡΠΊΠΎΠΉ Π΄Π΅ΡΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ, ΠΈ Π΄ΠΈΠ³ΠΈΡΠ°Π»ΠΈΠ·Π°ΡΠΈΡ, ΠΌΠ΅Π½ΡΡΡΠ°Ρ ΡΠΏΠΎΡΠΎΠ± ΠΊΠΎΠΌΠΌΡΠ½ΠΈΠΊΠ°ΡΠΈΠΈ ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΠ³ΠΎ ΠΈΠ½Π΄ΠΈΠ²ΠΈΠ΄Π° ΠΈ ΡΠΎΡΠΌΠΈΡΡΡΡΠ°Ρ Π½ΠΎΠ²ΡΠΉ "ΡΠΎΠΊΡΡ" Π²ΠΎΡΠΏΡΠΈΡΡΠΈΡ ΠΌΠΈΡΠ°, ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΡΡ ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΠ΅ "ΠΎΠ±ΡΠ΅ΡΡΠ²ΠΎ ΠΏΠ΅ΡΠ΅ΠΆΠΈΠ²Π°Π½ΠΈΠΉ" ΠΈ "ΡΠΊΠΎΠ½ΠΎΠΌΠΈΠΊΡ Π²ΠΏΠ΅ΡΠ°ΡΠ»Π΅Π½ΠΈΠΉ", ΡΡΠ°Π½ΡΡΠΎΡΠΌΠΈΡΡΡΡ Ρ
Π°ΡΠ°ΠΊΡΠ΅Ρ ΠΈ ΡΠ΅Π»Ρ ΡΠΎΡΠΈΠ°Π»ΡΠ½ΠΎΠ³ΠΎ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΡ, ΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΡ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° Ρ ΠΌΠΈΡΠΎΠΌ, Π²Π΅Π΄ΡΡ ΠΊ ΡΠΌΠ΅ΡΠ΅Π½ΠΈΡ ΡΠ΅Π½Π½ΠΎΡΡΠ½ΡΡ
ΠΎΡΠΈΠ΅Π½ΡΠΈΡΠΎΠ². Π ΡΠ°Π±ΠΎΡΠ΅ Π΄Π°Π΅ΡΡΡ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠ° ΠΊΠΎΠ½ΡΠ΅ΠΏΡΠΈΠΉ "ΠΎΠ±ΡΠ΅ΡΡΠ²Π° ΠΏΠ΅ΡΠ΅ΠΆΠΈΠ²Π°Π½ΠΈΠΉ", "ΡΠΊΠΎΠ½ΠΎΠΌΠΈΠΊΠΈ Π²ΠΏΠ΅ΡΠ°ΡΠ»Π΅Π½ΠΈΠΉ", "ΡΡΡΠ΅ΡΠΈΠ·Π°ΡΠΈΡ ΠΏΠΎΠ²ΡΠ΅Π΄Π½Π΅Π²Π½ΠΎΡΡΠΈ"; ΠΏΡΠΎΠ°Π½Π°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Π° ΡΠ²ΠΎΠ»ΡΡΠΈΡ ΡΡΠΈΡ
ΠΈΠ΄Π΅ΠΉ.The scientific and qualification work is devoted to the actual problem, caused by the controversial nature of the sociocultural changes caused by the "spatial turn", aesthetisation of everyday life and the experience society. Aesthetization, affecting all spheres of human activity, and digitalization, changing the way of communication of a modern individual and forming a new "focus" of the world perception determine the modern "experience society" and " experience economy", transform the nature and purpose of social interaction, human relations with the world, lead to the displacement of value points. The work describes the concepts of the "experience society", " experience economy", " aesthetisation of everyday life "; The evolution of these ideas is analyzed
Use Your Strategic Entrepreneurs to Build Your Strategic Partnerships
Internationalisation through strategic partnerships is a goal for many higher education institutions and their upper-level management teams. Yet for institutional objectives to truly flourish, they should get the most out of the various skills that different actors bring to be table. This piece explores the interesting role that can be played by resourceful academic staff in materialising institutional, and individual, aims
Metformin as a Therapeutic Target in Endometrial Cancers.
Endometrial cancer is the most common gynecologic malignancy in developed countries. Its increasing incidence is thought to be related in part to the rise of metabolic syndrome, which has been shown to be a risk factor for the development of hyperestrogenic and hyperinsulinemic states. This has consequently lead to an increase in other hormone-responsive cancers as well e.g., breast and ovarian cancer. The correlation between obesity, hyperglycemia, and endometrial cancer has highlighted the important role of metabolism in cancer establishment and persistence. Tumor-mediated reprogramming of the microenvironment and macroenvironment can range from induction of cytokines and growth factors to stimulation of surrounding stromal cells to produce energy-rich catabolites, fueling the growth, and survival of cancer cells. Such mechanisms raise the prospect of the metabolic microenvironment itself as a viable target for treatment of malignancies. Metformin is a biguanide drug that is a first-line treatment for type 2 diabetes that has beneficial effects on various markers of the metabolic syndrome. Many studies suggest that metformin shows potential as an adjuvant treatment for uterine and other cancers. Here, we review the evidence for metformin as a treatment for cancers of the endometrium. We discuss the available clinical data and the molecular mechanisms by which it may exert its effects, with a focus on how it may alter the tumor microenvironment. The pleiotropic effects of metformin on cellular energy production and usage as well as intercellular and hormone-based interactions make it a promising candidate for reprogramming of the cancer ecosystem. This, along with other treatments aimed at targeting tumor metabolic pathways, may lead to novel treatment strategies for endometrial cancer
Influence of bevacizumab on vaginal cuff evisceration eight months after ovarian cancer cytoreduction surgery: A case report.
β’44 year old woman treated with bevacizumab for metastatic epithelial ovarian cancerβ’The patient experienced vaginal cuff dehiscence and evisceration at 8 months post-operatively.β’Metastasis at the surgical site and chronic inflammation implicated
Experiences of hearing aid use among patients with mild cognitive impairment and Alzheimerβs disease dementia: A qualitative study
Objectives: Hearing aid usage supports communication and independence; however, many do not use their hearing aids. This study explored the experiences of hearing aid use in adults with mild cognitive impairment or Alzheimer's disease. Methods: Participants completed semi-structured interviews which were analysed using thematic analysis. Ten people (six males, age range 75-86βyears old) with mild cognitive impairment or Alzheimer's disease who had been fitted with hearing aids were recruited to the study. Results: We identified four major themes: (1) memory and other cognitive barriers to using hearing aids, (2) practical aspects of hearing aids, (3) benefits of hearing aids, and (4) ambivalence towards hearing aids. Conclusions: Participants perceived a significant impact of cognitive impairment on the experience of using hearing aids. This population may benefit from targeted strategies to support use of hearing aids. The findings from this study can inform future research to optimise use of hearing aids in this population
ΠΠΎΠ»ΡΡΠ΅Π½ΠΈΠ΅ ΠΈ ΡΠ²ΠΎΠΉΡΡΠ²Π° ΠΊΠ΅ΡΠ°ΠΌΠΈΡΠ΅ΡΠΊΠΈΡ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»ΠΎΠ² Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ ΡΠΈΡΡΠ΅ΠΌΡ Al[2]O[3]-MgO
It is known that aluminum oxide is the most generally used ceramic material applied as structural, functional and biomaterial. Meanwhile, it is used not only in a high state and but also in a highporous state. To obtain the required functional properties it is alloyed by various oxides such as FeO, SiO[2], Y[2]O[3], MgO and others. What most interested us is the magnasium oxide (MgO), as it is well known that the MgO presence in the ceramics materials causes biological processes activation at the boundary "implant - bone". However, the introduction of MgO into sintered mixture may change technological regimes of ceramics production and as a result to the structure and properties of the material can be changed as well. The aim of this work is to study the influence of the concentration of the injected mixture into the sintered MgO in the amount up to 10 wt. %. onto porosity, shrinkage characteristics of the microstructure and mechanical properties of the sintered material
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