301 research outputs found

    Patient‐Reported Outcomes From a Two‐Year Head‐to‐Head Comparison of Subcutaneous Abatacept and Adalimumab for Rheumatoid Arthritis

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    Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/122413/1/acr22763_am.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/122413/2/acr22763.pd

    Reductions in disease activity in the AMPLE trial: clinical response by baseline disease duration

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    Objectives: To evaluate clinical response by baseline disease duration using 2-year data from the AMPLE trial. Methods: Patients were randomised to subcutaneous abatacept 125 mg weekly or adalimumab 40 mg biweekly, with background methotrexate. As part of a post hoc analysis, the achievement of validated definitions of remission (Clinical Disease Activity Index (CDAI) ≤2.8, Simplified Disease Activity Index (SDAI) ≤3.3, Routine Assessment of Patient Index Data 3 (RAPID3) ≤3.0, Boolean score ≤1), low disease activity (CDAI \u3c10, SDAI \u3c11, RAPID3 ≤6.0), Health Assessment Questionnaire-Disability Index response and American College of Rheumatology responses were evaluated by baseline disease duration (≤6 vs \u3e6 months). Disease Activity Score 28 (C-reactive protein) \u3c2.6 or ≤3.2 and radiographic non-progression in patients achieving remission were also evaluated. Results: A total of 646 patients were randomised and treated (abatacept, n=318; adalimumab, n=328). In both treatment groups, comparable responses were achieved in patients with early rheumatoid arthritis (≤6 months) and in those with later disease (\u3e6 months) across multiple clinical measures Conclusions: Abatacept or adalimumab with background methotrexate were associated with similar onset and sustainability of response over 2 years. Patients treated early or later in the disease course achieved comparable clinical responses

    Formation of antihydrogen in antiproton - positron collision

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    A quantum mechanical approach is proposed for the formation of antihydrogen in the ground and excited states (2s, 2p) via the mechanism of three body recombination (TBR) inside a trapped plasma of anti proton and positron or in the collision between the two beams of them. Variations of the differential (DCS) as well as the total (TCS) formation cross sections are studied as a function of the incident energies of both the active and the spectator positrons. Significantly large cross sections are found at very low incident energies in the TBR process as compared to other processes leading to antihydrogen. The present formation cross section decreases with increasing positron energy (temperature) but no simple power law could be predicted for it covering the entire energy range, corroborating the experimental findings qualitatively. The formation cross sections are found to be much higher for unequal energies of the two positrons than for equal energies, as expected physically.Comment: 14 pages, 13 figure

    An assessment of the measurement of the Lense-Thirring effect in the Earth gravity field, in reply to: ``On the measurement of the Lense-Thirring effect using the nodes of the LAGEOS satellites, in reply to ``On the reliability of the so far performed tests for measuring the Lense-Thirring effect with the LAGEOS satellites'' by L. Iorio,'' by I. Ciufolini and E. Pavlis

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    In this paper we reply to recent claims by Ciufolini and Pavlis about certain aspects of the measurement of the general relativistic Lense-Thirring effect in the gravitational field of the Earth. I) The proposal by such authors of using the existing satellites endowed with some active mechanism of compensation of the non-gravitational perturbations as an alternative strategy to improve the currently ongoing Lense-Thirring tests is unfeasible because of the impact of the uncancelled even zonal harmonics of the geopotential and of some time-dependent tidal perturbations. II) It is shown that their criticisms about the possibility of using the existing altimeter Jason-1 and laser-ranged Ajisai satellites are groundless.III) Ciufolini and Pavlis also claimed that we would have explicitly proposed to use the mean anomaly of the LAGEOS satellites in order to improve the accuracy of the Lense-Thirrring tests. We prove that it is false. In regard to the mean anomaly of the LAGEOS satellites, Ciufolini himself did use such an orbital element in some previously published tests. About the latest test performed with the LAGEOS satellites, IV) we discuss the cross-coupling between the inclination errors and the first even zonal harmonic as another possible source of systematic error affecting it with an additional 9% bias. V) Finally, we stress the weak points of the claims about the origin of the two-nodes LAGEOS-LAGEOS II combination used in that test.Comment: LaTex2e, 22 pages, no figures, no tables. To appear in Planetary and Space Science. Reference Ries et al. 2003a added and properly cite

    Restricted feedback control of one-dimensional maps

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    Dynamical control of biological systems is often restricted by the practical constraint of unidirectional parameter perturbations. We show that such a restriction introduces surprising complexity to the stability of one-dimensional map systems and can actually improve controllability. We present experimental cardiac control results that support these analyses. Finally, we develop new control algorithms that exploit the structure of the restricted-control stability zones to automatically adapt the control feedback parameter and thereby achieve improved robustness to noise and drifting system parameters.Comment: 29 pages, 9 embedded figure
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