Conceptions of experimental control in 19th-century life sciences

This article presents a new framework for the analysis of experimental control. The framework highlights different functions for experimental controls in the realization of an experiment: experimental controls that serve as tests and experimental controls that serve as probes. The approach to experimental control proposed here can illuminate the constitutive role of controls in knowledge production, and it sheds new light on the notion of exploratory experimentation. It also clarifies what can and what cannot be expected from reviewers of scientific journal articles giving feedback on experimental controls

Genres of Justification

This article identifies a fundamental distinction in scientific practice: the mismatch between what scientists do and what they state they did when they communicate their findings in their publications. The insight that such a mismatch exists is not new. It was already implied in Hans Reichenbach’s distinction between the contexts of discovery and justification, and it is taken for granted across the board in philosophy of science and science studies. But while there is general agreement that the mismatch exists, the epistemological implications of that mismatch are not at all clear. Philosophers, historians, and sociologists of different stripes have expressed widely different views about how one should understand and interpret the relation between what scientists do and what they state they did. This article surveys a number of approaches to the mismatch. Based on this survey, I offer an assessment of the epistemological significance of the mismatch and identify the major meta?epistemological challenges that it poses for the analysis of scientific practic

The Structure and Function of Experimental Control in the Life Sciences

This article presents a new framework for the analysis of experimental control. The framework highlights different functions for experimental controls in the realization of an experiment: experimental controls that serve as tests and experimental controls that serve as probes. The approach to experimental control proposed here can illuminate the constitutive role of controls in knowledge production, and it sheds new light on the notion of exploratory experimentation. It also clarifies what can and what cannot be expected from reviewers of scientific journal articles giving feedback on experimental controls

About method: experimenters, snake venom, and the history of writing scientifically

Scientists’ views on what makes an experiment successful have developed dramatically throughout history. Different criteria for proper experimentation were privileged at different times, entirely new criteria for securing experimental results emerged, and the meaning of commitment to experimentation altered. In About Method, Schickore captures this complex trajectory of change from 1660 to the twentieth century through the history of snake venom research. As experiments with poisonous snakes and venom were both challenging and controversial, the experimenters produced very detailed accounts of their investigations, which go back three hundred years—making venom research uniquely suited for such a long-term study. By analyzing key episodes in the transformation of venom research, Schickore is able to draw out the factors that have shaped methods discourse in science.   About Method shows that methodological advancement throughout history has not been simply a steady progression toward better, more sophisticated and improved methodologies of experimentation. Rather, it was a progression in awareness of the obstacles and limitations that scientists face in developing strategies to probe the myriad unknown complexities of nature. The first long-term history of this development and of snake venom research, About Method offers a major contribution to integrated history and philosophy of science