13 research outputs found
Examining a Ripple Effect: Do Spousesâ Behavior Changes Predict Each Otherâs Weight Loss?
Background. Including spouses in obesity treatment has been found to promote weight loss. We assessed whether spousesâ diet and activity changes impacted each otherâs weight loss when both members attended an active weight loss program (TOGETHER) or only the primary participant attended treatment (ALONE).
Methods. Heterosexual couples () enrolled in an 18-month randomized controlled weight loss trial were weighed and completed measures of dietary intake and physical activity at baseline and 6 months. We conducted dyadic data analyses using the Actor-Partner Interdependence Model.
Results. Participantsâ weight loss was not predicted by their partnersâ behavior changes. However, partnersâ weight loss was predicted by their participantsâ changes in calorie and fat intake. When partners were coupled with a participant who did not reduce their own calorie and fat intake as much, these partners had higher weight loss when treated in the TOGETHER group but lower weight loss when they were untreated in the ALONE group. There were no reciprocal effects found with physical activity changes.
Conclusions. Direct treatment had the greatest impact on participants and partners who were treated. Untreated partnersâ weight losses were positively impacted by their spousesâ dietary changes, suggesting a ripple effect from treated spouses to their untreated partners
Overcoming Innocentsâ NaivetĂ©: Preâinterrogation Decisionâmaking Among Innocent Suspects
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/133623/1/bsl2247.pd
High-mobility group box 1 protein, receptor for advanced glycation end products and nucleosomes increases after marathon
Background: Prolonged and strenuous exercise has been linked to potential exercise-induced myocardial damages. One potential key to unmask the discussed underlying mechanisms of this subclinical cardiac damage could be markers of immunogenic cell damage (ICD). We investigated the kinetics of high-mobility group box 1 protein (HMGB1), soluble receptor for advanced glycation end products (sRAGE), nucleosomes, high sensitive troponin T (hs-TnT) and high sensitive C-reactive protein (hs-CRP) before and up to 12 weeks post-race and described associations with routine laboratory markers and physiological covariates. Methods: In our prospective longitudinal study, 51 adults (82% males; 43 ± 9 years) were included. All participants underwent a cardiopulmonary evaluation 10-12 weeks pre-race. HMGB1, sRAGE, nucleosomes, hs-TnT and, hs-CRP were analysed 10-12 weeks prior, 1-2 weeks before, immediately, 24 h, 72 h, and 12 weeks post-race. Results: HMGB1, sRAGE, nucleosomes and hs-TnT increased significantly from pre- to immediately post-race (0.82-2.79 ng/mL; 1132-1388 pg/mL; 9.24-56.65 ng/mL; 6-27 ng/L; p < 0.001) and returned to baseline within 24-72 h. Hs-CRP increased significantly 24 h post-race (0.88-11.5 mg/L; p < 0.001). Change in sRAGE was positively associated with change in hs-TnT (rs = 0.352, p = 0.011). Longer marathon finishing time was significantly associated with decreased levels of sRAGE [-9.2 pg/mL (ÎČ = -9.2, SE = 2.2, p < 0.001)]. Conclusion: Prolonged and strenuous exercise increases markers of ICD immediately post-race, followed by a decrease within 72 h. An acute marathon event results in transient alterations of ICD, we assume that this is not solely driven by myocyte damages
Examining a Ripple Effect: Do Spousesâ Behavior Changes Predict Each Otherâs Weight Loss?
Background. Including spouses in obesity treatment has been found to promote weight loss. We assessed whether spousesâ diet and activity changes impacted each otherâs weight loss when both members attended an active weight loss program (TOGETHER) or only the primary participant attended treatment (ALONE).
Methods. Heterosexual couples () enrolled in an 18-month randomized controlled weight loss trial were weighed and completed measures of dietary intake and physical activity at baseline and 6 months. We conducted dyadic data analyses using the Actor-Partner Interdependence Model.
Results. Participantsâ weight loss was not predicted by their partnersâ behavior changes. However, partnersâ weight loss was predicted by their participantsâ changes in calorie and fat intake. When partners were coupled with a participant who did not reduce their own calorie and fat intake as much, these partners had higher weight loss when treated in the TOGETHER group but lower weight loss when they were untreated in the ALONE group. There were no reciprocal effects found with physical activity changes.
Conclusions. Direct treatment had the greatest impact on participants and partners who were treated. Untreated partnersâ weight losses were positively impacted by their spousesâ dietary changes, suggesting a ripple effect from treated spouses to their untreated partners
High-mobility group box 1 protein, receptor for advanced glycation end products and nucleosomes increases after marathon
Background: Prolonged and strenuous exercise has been linked to potential exercise-induced myocardial damages. One potential key to unmask the discussed underlying mechanisms of this subclinical cardiac damage could be markers of immunogenic cell damage (ICD). We investigated the kinetics of high-mobility group box 1 protein (HMGB1), soluble receptor for advanced glycation end products (sRAGE), nucleosomes, high sensitive troponin T (hs-TnT) and high sensitive C-reactive protein (hs-CRP) before and up to 12Â weeks post-race and described associations with routine laboratory markers and physiological covariates.
Methods: In our prospective longitudinal study, 51 adults (82% males; 43 ± 9 years) were included. All participants underwent a cardiopulmonary evaluation 10â12 weeks pre-race. HMGB1, sRAGE, nucleosomes, hs-TnT and, hs-CRP were analysed 10â12 weeks prior, 1â2 weeks before, immediately, 24 h, 72 h, and 12 weeks post-race.
Results: HMGB1, sRAGE, nucleosomes and hs-TnT increased significantly from pre- to immediately post-race (0.82â2.79Â ng/mL; 1132â1388Â pg/mL; 9.24â56.65Â ng/mL; 6â27Â ng/L; p < 0.001) and returned to baseline within 24â72Â h. Hs-CRP increased significantly 24Â h post-race (0.88â11.5Â mg/L; p < 0.001). Change in sRAGE was positively associated with change in hs-TnT (rs = 0.352, p = 0.011). Longer marathon finishing time was significantly associated with decreased levels of sRAGE [â9.2Â pg/mL (ÎČ = â9.2, SE = 2.2, p < 0.001)].
Conclusion: Prolonged and strenuous exercise increases markers of ICD immediately post-race, followed by a decrease within 72Â h. An acute marathon event results in transient alterations of ICD, we assume that this is not solely driven by myocyte damages