Using DSpace as a Disciplinary Data Repository

4th International Conference on Open RepositoriesThis presentation was part of the session : DSpace User Group PresentationsDate: 2009-05-20 03:30 PM – 05:00 PMDryad (http://datadryad.org) is a disciplinary repository for datasets underlying published works in biology. Dryad allows investigators to validate published findings, explore new analysis methodologies, and repurpose data for research questions unanticipated by the original authors. Dryad partners with a coalition of scientific societies and journals to encourage deposition of data and to facilitate automatic metadata collection. DSpace fits many of Dryad's needs, but the needs of a disciplinary repository and the needs of a data repository impose constraints not met by off-the-shelf DSpace functionality. These constraints affect both repository organization and features. For example, the community/collection boundaries native to DSpace conflict with the overlapping concerns of biology sub-disciplines, so the communities and collections have been hidden from users. Because the step-by-step DSpace submission process does not accommodate the workflow required to store data associated with publications, a completely new submission system has been implemented. To meet the needs of its user community, Dryad must integrate with other repositories and services. Dryad is developing functionality to search harvested content from specialized repositories, to link between Dryad content and external content, and to facilitate submission of Dryad content to specialized repositories. This presentation details the differences between the needs of Dryad and a general institutional repository, and describes the modifications made to DSpace to accommodate those differences.National Science Foundatio

Searching Digital Content via SRU

A recording is not available for this presentation

Shopping Context and the Impulsive and Compulsive Buyer

Impulsive and compulsive buying are behaviors with unique antecedents and consequences. Each has been studied at length but not in the duel context of offline and online retail environments. This current research examines the interaction of shopping context (online or offline) in relation to impulsive and compulsive buying behaviors. We find evidence that compulsive buying tendency is positively associated with online shopping, while impulse buying tendency is positively associated with offline shopping. The implications of this research suggest that purchasing as a result of compulsive and impulsive buying tendencies vary as a result of the shopping context which includes physical proximity to product and store atmospherics. This study reports the behavior of 353 young adults who provide a survey and shopping diary data over a two-week period during the U.S. holiday of Thanksgiving

Konzeption und Evaluierung einer domänenspezifischen Modellierungsumgebung für prozessorientierte Fragebögen

Zur Datenerfassung in klinischen oder psychologischen Studien werden oft sogenannte "Papier und Bleistift"-Fragebögen eingesetzt. Dieser papierbasierte Ansatz bringt allerdings viel Zusatzaufwand mit sich – beispielsweise für die nachgelagerte Analyse der so erhobenen Daten, da diese manuell in digitale Auswertungstabellen übertragen werden müssen. Um diesen Medienbruch zu vermeiden, wurden bereits erste digitale Fragebogen-Anwendungen realisiert, die weitere Anforderungen aufgezeigt haben. So ist die Erstellung und anschließende Wartbarkeit solcher Anwendungen zur Datenerhebung bisher lediglich IT-Experten vorbehalten. Ziel muss es sein, ein System zu entwerfen, das es Experten aus beliebigen Domänen ermöglicht, eigene Fragebögen zu erstellen, um eine Datenerhebung auf mobilen Endgeräten durchzuführen. Diese Arbeit liefert ein umfangreiches Konzept für ein solches System. Der Fokus wird dabei auf die Modellierung von Fragebögen gelegt. In der hier beschriebenen Methodik werden Prozesse dazu verwendet, Fragebögen abzubilden. Dazu wird eine vereinfachte Modellierungssprache mit einer reduzierten Auswahl an Modellierungselementen vorgestellt, die verwendet werden kann, um Fragebögen modellbasiert zu erstellen. Darüber hinaus wird ein Konzept vorgestellt, das diese Modellierungsumgebung in ein Gesamtsystem integriert. Hierfür wurden Anforderungen an ein solches System erfasst, dokumentiert und analysiert. Es wurden vor allem auch Anforderungen an die Benutzeroberfläche, die im Falle der Modellierung enorm wichtig sind, kritisch diskutiert und eigene Konzepte entwickelt. Um das in dieser Arbeit entworfene Modellierungskonzept zu evaluieren, wurden verschiedene Prototypen iterativ implementiert. Diese wurden von Experten aus verschiedenen Domänen untersucht und evaluiert. Die Erkenntnisse dieser Analysen wurden für die weiteren Arbeiten herangezogen um ein durchgängiges und in sich schlüssiges Modellierungskonzept zu erstellen. Diese Arbeit zeigt auf, welche Vorteile die Modellierung von Fragebögen bringt und bietet mit dem vorgestellten Konzept einen in sich geschlossenen und umfangreichen Ansatz zur Umsetzung eines solchen Konfigurators zur Modellierung von Fragebögen

Gait speed testing in the emergency department: A nursing pilot project

Background: Objective functional screening tools are an important component of the assessment of older adults in the emergency department (ED) setting and are identified as a predictor of adverse events including ED revisits and falls. Gait speed is an easy screening tool that can be performed quickly and safely during the triage process without delaying the care of the patient. A gait speed of 1.0m/s). Discharge disposition was categorized as discharged, discharged with physical therapy, and discharged with other support services. Data analysis consisted of descriptive statistics and the Fisher’s exact test. Results: The sample was primarily female (n=19 , 63.3%), with a mean age of 71years (SD=8.9). The mean gait speed was .75m/s (SD=.25 Twenty-three patients had low gait speed < 1 m/s. Of those patients with low gait speed, 8 patients (34.8%) were admitted while 15 (65.2%) were discharged home, a result that was not statistically significant (P=1.00, Fisher’s exact test). Conclusion: Gait speed testing could be administered by nursing during the triage process without delaying the patient’s length of stay. In this limited sample, gait speed testing did not impact the use of support services upon discharge. Further staff education is warranted to increase their understanding of the clinical implications of gait speed testing.D.N.P., Nursing Practice -- Drexel University, 201

Indoleamine 2,3-Dioxygenase and Its Therapeutic Inhibition in Cancer

The tryptophan catabolic enzyme indoleamine 2,3-dioxygenase-1 (IDO1) has attracted enormous attention in driving cancer immunosuppression, neovascularization, and metastasis. IDO1 suppresses local CD8 + T effector cells and natural killer cells and induces CD4 + T regulatory cells (iTreg) and myeloid-derived suppressor cells (MDSC). The structurally distinct enzyme tryptophan dioxygenase (TDO) also has been implicated recently in immune escape and metastatic progression. Lastly, emerging evidence suggests that the IDO1-related enzyme IDO2 may support IDO1-mediated iTreg and contribute to B-cell inflammed states in certain cancers. IDO1 and TDO are upregulated widely in neoplastic cells but also variably in stromal, endothelial, and innate immune cells of the tumor microenviroment and in tumor-draining lymph nodes. Pharmacological and genetic proofs in preclinical models of cancer have validated IDO1 as a cancer therapeutic target. IDO1 inhibitors have limited activity on their own but greatly enhance “immunogenic” chemotherapy or immune checkpoint drugs. IDO/TDO function is rooted in inflammatory programming, thereby influencing tumor neovascularization, MDSC generation, and metastasis beyond effects on adaptive immune tolerance. Discovery and development of two small molecule enzyme inhibitors of IDO1 have advanced furthest to date in Phase II/III human trials (epacadostat and navoximod, respectively). Indoximod, a tryptophan mimetic compound with a different mechanism of action in the IDO pathway has also advanced in multiple Phase II trials. Second generation combined IDO/TDO inhibitors may broaden impact in cancer treatment, for example, in addressing IDO1 bypass (inherent resistance) or acquired resistance to IDO1 inhibitors. This review surveys knowledge about IDO1 function and how IDO1 inhibitors reprogram inflammation to heighten therapeutic responses in cancer

Indoleamine 2,3-Dioxygenase and Its Therapeutic Inhibition in Cancer

The tryptophan catabolic enzyme indoleamine 2,3-dioxygenase-1 (IDO1) has attracted enormous attention in driving cancer immunosuppression, neovascularization, and metastasis. IDO1 suppresses local CD8 + T effector cells and natural killer cells and induces CD4 + T regulatory cells (iTreg) and myeloid-derived suppressor cells (MDSC). The structurally distinct enzyme tryptophan dioxygenase (TDO) also has been implicated recently in immune escape and metastatic progression. Lastly, emerging evidence suggests that the IDO1-related enzyme IDO2 may support IDO1-mediated iTreg and contribute to B-cell inflammed states in certain cancers. IDO1 and TDO are upregulated widely in neoplastic cells but also variably in stromal, endothelial, and innate immune cells of the tumor microenviroment and in tumor-draining lymph nodes. Pharmacological and genetic proofs in preclinical models of cancer have validated IDO1 as a cancer therapeutic target. IDO1 inhibitors have limited activity on their own but greatly enhance “immunogenic” chemotherapy or immune checkpoint drugs. IDO/TDO function is rooted in inflammatory programming, thereby influencing tumor neovascularization, MDSC generation, and metastasis beyond effects on adaptive immune tolerance. Discovery and development of two small molecule enzyme inhibitors of IDO1 have advanced furthest to date in Phase II/III human trials (epacadostat and navoximod, respectively). Indoximod, a tryptophan mimetic compound with a different mechanism of action in the IDO pathway has also advanced in multiple Phase II trials. Second generation combined IDO/TDO inhibitors may broaden impact in cancer treatment, for example, in addressing IDO1 bypass (inherent resistance) or acquired resistance to IDO1 inhibitors. This review surveys knowledge about IDO1 function and how IDO1 inhibitors reprogram inflammation to heighten therapeutic responses in cancer

Characterization of G-protein α subunits in the Gq class: expression in murine tissues and in stromal and hematopoietic cell lines

Murine Gα14 and Gα15 cDNAs encode distinct α subunits of heterotrimeric guanine nucleotide-binding proteins (G proteins). These alpha subunits are related to members of the Gq class and share certain sequence characteristics with Gαq, Gα11, and Gα16, such as the absence of a pertussis toxin ADP-ribosylation site. Gα11 and Gαq are ubiquitously expressed among murine tissues but G alpha 14 is predominantly expressed in spleen, lung, kidney, and testis whereas Gα15 is primarily restricted to hematopoietic lineages. Among hematopoietic cell lines, Gα11 mRNA is found in all cell lines tested, Gαq is expressed widely but is not found in most T-cell lines, Gα15 is predominantly expressed in myeloid and B-cell lineages, and Gα14 is expressed in bone marrow adherent (stromal) cells, certain early myeloid cells, and progenitor B cells. Polyclonal antisera produced from synthetic peptides that correspond to two regions of Gα15 react with a protein of 42 kDa expressed in B-cell membranes and in Escherichia coli transformed with Gα15 cDNA. The expression patterns that were observed in mouse tissues and cell lines indicate that each of the alpha subunits in the Gq class may be involved in pertussis toxin-insensitive signal-transduction pathways that are fundamental to hematopoietic cell differentiation and function