1 research outputs found
Entropy loss in long-distance DNA looping
The entropy loss due to the formation of one or multiple loops in circular
and linear DNA chains is calculated from a scaling approach in the limit of
long chain segments. The analytical results allow to obtain a fast estimate for
the entropy loss for a given configuration. Numerical values obtained for some
examples suggest that the entropy loss encountered in loop closure in typical
genetic switches may become a relevant factor which has to be overcome by the
released bond energy between the looping contact sites.Comment: 7 pages, 3 figure