2,028 research outputs found
Statistical-mechanical lattice models for protein-DNA binding in chromatin
Statistical-mechanical lattice models for protein-DNA binding are well
established as a method to describe complex ligand binding equilibriums
measured in vitro with purified DNA and protein components. Recently, a new
field of applications has opened up for this approach since it has become
possible to experimentally quantify genome-wide protein occupancies in relation
to the DNA sequence. In particular, the organization of the eukaryotic genome
by histone proteins into a nucleoprotein complex termed chromatin has been
recognized as a key parameter that controls the access of transcription factors
to the DNA sequence. New approaches have to be developed to derive statistical
mechanical lattice descriptions of chromatin-associated protein-DNA
interactions. Here, we present the theoretical framework for lattice models of
histone-DNA interactions in chromatin and investigate the (competitive) DNA
binding of other chromosomal proteins and transcription factors. The results
have a number of applications for quantitative models for the regulation of
gene expression.Comment: 19 pages, 7 figures, accepted author manuscript, to appear in J.
Phys.: Cond. Mat
A High Statistics Search for Electron-Neutrino --> Tau-Neutrino Oscillations
We present new limits on nu_e to nu_tau and nu_e to nu_sterile oscillations
by searching for electron neutrino dissappearance in the high-energy wide-band
CCFR neutrino beam. Sensitivity to nu_tau appearance comes from tau decay modes
in which a large fraction of the energy deposited is electromagnetic. The beam
is composed primarily of muon neutrinos but this analysis uses the 2.3%
electron neutrino component of the beam. Electron neutrino energies range from
30 to 600 GeV and flight lengths vary from 0.9 to 1.4 km. This limit improves
the sensitivity of existing limits and obtains a lowest 90% confidence upper
limit in sin**2(2*alpha) of 9.9 x 10**(-2) at delta-m**2 of 125 eV**2.Comment: submitted to Phys. Rev. D. Rapid Com
Parton Distributions Working Group
The main focus of this working group was to investigate the different issues
associated with the development of quantitative tools to estimate parton
distribution functions uncertainties. In the conclusion, we introduce a
"Manifesto" that describes an optimal method for reporting data.Comment: Report of the Parton Distributions Working Group of the 'QCD and Weak
Boson Physics workshop in preparation for Run II at the Fermilab Tevatron'.
Co-Conveners: L. de Barbaro, S.A. Keller, S. Kuhlmann, H. Schellman, and
W.-K. Tun
Renaissance of the ~1 TeV Fixed-Target Program
This document describes the physics potential of a new fixed-target program
based on a ~1 TeV proton source. Two proton sources are potentially available
in the future: the existing Tevatron at Fermilab, which can provide 800 GeV
protons for fixed-target physics, and a possible upgrade to the SPS at CERN,
called SPS+, which would produce 1 TeV protons on target. In this paper we use
an example Tevatron fixed-target program to illustrate the high discovery
potential possible in the charm and neutrino sectors. We highlight examples
which are either unique to the program or difficult to accomplish at other
venues.Comment: 31 pages, 11 figure
New Measurements of Nucleon Structure Functions from CCFR/NuTeV
We report on the extraction of the structure functions F_2 and Delta xF_3 =
xF_3nu-xF_3nub from CCFR neutrino-Fe and antineutrino-Fe differential cross
sections. The extraction is performed in a physics model independent (PMI) way.
This first measurement for Delta xF_3, which is useful in testing models of
heavy charm production, is higher than current theoretical predictions. Within
5% the F_2 (PMI) values measured in neutrino and muon scattering are in
agreement with the predictions of Next-to-Leading-Order PDFs (using massive
charm production schemes), thus resolving the long-standing discrepancy between
the two measurements.Comment: 3 pages, Presented by Arie Bodek at DPF2000 Conference, Columbus,
Ohio, Aug. 200
Reducing model bias in a deep learning classifier using domain adversarial neural networks in the MINERvA experiment
We present a simulation-based study using deep convolutional neural networks
(DCNNs) to identify neutrino interaction vertices in the MINERvA passive
targets region, and illustrate the application of domain adversarial neural
networks (DANNs) in this context. DANNs are designed to be trained in one
domain (simulated data) but tested in a second domain (physics data) and
utilize unlabeled data from the second domain so that during training only
features which are unable to discriminate between the domains are promoted.
MINERvA is a neutrino-nucleus scattering experiment using the NuMI beamline at
Fermilab. -dependent cross sections are an important part of the physics
program, and these measurements require vertex finding in complicated events.
To illustrate the impact of the DANN we used a modified set of simulation in
place of physics data during the training of the DANN and then used the label
of the modified simulation during the evaluation of the DANN. We find that deep
learning based methods offer significant advantages over our prior track-based
reconstruction for the task of vertex finding, and that DANNs are able to
improve the performance of deep networks by leveraging available unlabeled data
and by mitigating network performance degradation rooted in biases in the
physics models used for training.Comment: 41 page
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