Comparison of granulocyte colony-stimulating factor (G-CSF)--mobilized peripheral blood progenitor cells and G-CSF--stimulated bone marrow as a source of stem cells in HLA-matched sibling transplantation

AbstractHLA-identical bone marrow or stem cell transplantation from a sibling is the preferred treatment for patients with chronic myelogenous leukemia, bone marrow failure syndromes, relapsed acute leukemia, and specific inborn errors of metabolism. Several groups have shown that granulocyte colony-stimulating factor (G-CSF)--mobilized peripheral blood progenitor cells (PBPCs) obtained from HLA-matched siblings are effective in reconstitution of marrow function after marrow ablative conditioning therapy. To evaluate whether G-CSF treatment before bone marrow harvest leads to enhanced recovery of PBPC counts and recovery from limited graft-versus-host disease (GVHD), we assessed the outcome of a sequential cohort of patients treated identically and then given either G-CSF--mobilized PBPCs or G-CSF--stimulated bone marrow from HLA-identical siblings. We show that the time to neutrophil engraftment is identical in the 2 cohorts, whereas platelet engraftment is earlier with the use of PBPCs. The incidence of acute GVHD was decreased, and that of chronic GVHD significantly decreased, in the group receiving bone marrow. Overall survival was not different between the 2 groups. Thus, G-CSF--stimulated bone marrow offers a source of stem cells that allows for early neutrophil engraftment with a decreased risk of GVHD.Biol Blood Marrow Transplant 2000;6(4A):434-40

Remodeling Shared Governance: Feminist Decision Making and Resistance in Academic Neoliberalism

The shared governance model was conceived to attempt to respect the interests of external and internal groups, even when criticism flows at a constant rate. The phrase shared governance is so hackneyed that it is becoming what some linguists call an empty or floating signifier, a term so devoid of determinate meaning that it takes on whatever significance a particular speaker gives it at the moment. Some material and ideological shifts that promoted a more transparent governance process included regular clear and specific updates about governance, creation of a blog, transparent calls for committee and leadership positions, increase in dialogic meeting time, and open access to information. Last, at all levels of academic governance, control of the narrative—and control of the discourse—shapes material and ideological dimensions. A feminist shared governance model may mean importing and reimagining traditional labor practices in ways that preserve the traditional principles of dialogue, engagement, governance by expertise rather than position, and collaboration of equals