Angiolymphoid Hyperplasia With Eosinophilia‐Acquired Port‐Wine‐Stain–Like Lesions: Attempt At Treatment With The Argon Laser

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/110832/1/hed00011.pd

T1 and ECV Mapping in Myocardial Disease

T1 mapping using cardiovascular magnetic resonance (CMR) introduces novel techniques for myocardial tissue characterization to detect and quantify disease processes occurring at the microscopic level. Even though T1 mapping has limited spatial resolution, cellular and molecular changes occurring within each voxel can affect the aggregate T1 signal rendering them quantifiable. The estimated T1-based parameters quantified on a “map” demonstrate the spatial localization of these changes whereby each pixel expresses the quantitative value of that parameter. This quantification permits detection of diffuse disease even if it is not directly visible. Rather than relying on nonspecific functional measures, T1 mapping focuses on intrinsic changes of myocardial composition that advances understanding about specific disease pathways. These changes in myocardial tissue composition inform diagnosis and prognosis. T1 mapping encompasses two key parameters: native (i.e., precontrast) T1 and extracellular volume fraction (ECV) derived from additional postcontrast T1 and blood T1 measurements. These advances introduce new tools to detect focal and diffuse myocardial derangements occurring in cardiac disease that can be otherwise difficult to detect. T1 and ECV mapping foster precision medicine and personalized care, promising to improve patient outcomes through targeted therapy. Capitalizing on the opportunities introduced by T1 mapping and ECV requires further investigation

Extracellular volume fraction is associated with B-type natriuretic peptide in hypertrophic cardiomyopathy

Hypertrophic cardiomyopathy is a common cardiovascular genetic disease characterized by sarcomeric gene mutations which lead to findings of cardiac hypertrophy, myocyte disarray, and fibrosis. While late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) detects focal, macroscopic regions of replacement fibrosis non-invasively, novel T1 CMR measurement techniques including extracellular volume fraction (ECV) diffuse interstitial fibrosis throughout the myocardium. Plasma B-type natriuretic peptide levels are often elevated in situations of increased wall tension and volume overload. Given that such states may be associated with myocardial fibrosis, and because BNP levels provide independent prognostic insight in HCM, we sought to determine the association between BNP and ECV measurement by CMR

Feasibility of the REDCap platform for Single Center and Collaborative Multicenter CMR Research

REDCap (Research Enterprise Data CAPture) software may provide a feasible platform for CMR Centers to: a) capture clinical throughput securely for research purposes, and 2) collaborate using a common platform for either distributed or centralized data storage. REDCap may facilitate CMR Centers' participation in the research enterprise, especially those with limited resources. REDCap may catalyze multicenter studies with "distributed data collection" where CMR sites can clone shared data dictionaries across sites for subsequent compilation into a singular master data file