Formation of proto-globular cluster candidates in cosmological simulations of dwarf galaxies at z>4z>4

We perform cosmological hydrodynamical simulations to study the formation of proto-globular cluster candidates in progenitors of present-day dwarf galaxies $(M_{\rm vir} \approx 10^{10}\, {\rm M}_\odot$ at $z=0$) as part of the "Feedback in Realistic Environment" (FIRE) project. Compact ($r_{1/2}<30$ pc), relatively massive ($0.5 \times 10^5 \lesssim M_{\star}/{\rm M}_\odot \lesssim 5\times10^5$), self-bound stellar clusters form at $11\gtrsim z \gtrsim 5$ in progenitors with $M_{\rm vir} \approx 10^9\,{\rm M}_\odot$. Cluster formation is triggered when at least $10^7\,{\rm M}_\odot$ of dense, turbulent gas reaches $\Sigma_{\rm gas} \approx 10^4\, {\rm M}_\odot\, {\rm pc}^{-2}$ as a result of the compressive effects of supernova feedback or from cloud-cloud collisions. The clusters can survive for $2-3\,{\rm Gyr}$; absent numerical effects, they would likely survive substantially longer, perhaps to $z=0$. The longest-lived clusters are those that form at significant distance -- several hundreds of pc -- from their host galaxy. We therefore predict that globular clusters forming in progenitors of present-day dwarf galaxies will be offset from any pre-existing stars within their host dark matter halos as opposed to deeply embedded within a well-defined galaxy. Properties of the nascent clusters are consistent with observations of some of the faintest and most compact high-redshift sources in \textit{Hubble Space Telescope} lensing fields and are at the edge of what will be detectable as point sources in deep imaging of non-lensed fields with the \textit{James Webb Space Telescope}. By contrast, the star clusters' host galaxies will remain undetectable.Comment: 14 pages, 5 figures, submitted to MNRA

Clinically Suspected Myocarditis Temporally Related to COVID-19 Vaccination in Adolescents and Young Adults: Suspected Myocarditis After COVID-19 Vaccination

Background: Understanding the clinical course and short-term outcomes of suspected myocarditis after the coronavirus disease 2019 (COVID-19) vaccination has important public health implications in the decision to vaccinate youth. Methods: We retrospectively collected data on patients <21 years old presenting before July 4, 2021, with suspected myocarditis within 30 days of COVID-19 vaccination. Lake Louise criteria were used for cardiac MRI findings. Myocarditis cases were classified as confirmed or probable on the basis of the Centers for Disease Control and Prevention definitions. Results: We report on 139 adolescents and young adults with 140 episodes of suspected myocarditis (49 confirmed, 91 probable) at 26 centers. Most patients were male (n=126, 90.6%) and White (n=92, 66.2%); 29 (20.9%) were Hispanic; and the median age was 15.8 years (range, 12.1–20.3; interquartile range [IQR], 14.5–17.0). Suspected myocarditis occurred in 136 patients (97.8%) after the mRNA vaccine, with 131 (94.2%) after the Pfizer-BioNTech vaccine; 128 (91.4%) occurred after the second dose. Symptoms started at a median of 2 days (range, 0–22; IQR, 1–3) after vaccination. The most common symptom was chest pain (99.3%). Patients were treated with nonsteroidal anti-inflammatory drugs (81.3%), intravenous immunoglobulin (21.6%), glucocorticoids (21.6%), colchicine (7.9%), or no anti-inflammatory therapies (8.6%). Twenty-six patients (18.7%) were in the intensive care unit, 2 were treated with inotropic/vasoactive support, and none required extracorporeal membrane oxygenation or died. Median hospital stay was 2 days (range, 0–10; IQR, 2–3). All patients had elevated troponin I (n=111, 8.12 ng/mL; IQR, 3.50–15.90) or T (n=28, 0.61 ng/mL; IQR, 0.25–1.30); 69.8% had abnormal ECGs and arrhythmias (7 with nonsustained ventricular tachycardia); and 18.7% had left ventricular ejection fraction <55% on echocardiogram. Of 97 patients who underwent cardiac MRI at a median 5 days (range, 0–88; IQR, 3–17) from symptom onset, 75 (77.3%) had abnormal findings: 74 (76.3%) had late gadolinium enhancement, 54 (55.7%) had myocardial edema, and 49 (50.5%) met Lake Louise criteria. Among 26 patients with left ventricular ejection fraction <55% on echocardiogram, all with follow-up had normalized function (n=25). Conclusions: Most cases of suspected COVID-19 vaccine myocarditis occurring in persons <21 years have a mild clinical course with rapid resolution of symptoms. Abnormal findings on cardiac MRI were frequent. Future studies should evaluate risk factors, mechanisms, and long-term outcomes