In-medium Production of Kaons at the Mean-Field Level

The in-medium mass and energy of kaons and antikaons are studied within the Relativistic Mean Field approach and compared with predictions from chiral models by taking care of kaon-nucleon scattering data. Implications for the subthreshold production of kaons and antikaons in heavy-ion collisions are discussed. We find only small corrections due to in-medium effects on the mean-field level for the relevant production processes for kaons. The production of kaons is even less favourable at high density due to repulsive vector interactions. We conclude that one has to go beyond mean-field approaches and take fluctuations and secondary production processes into account to explain the recently measured enhancement of kaon production at subthreshold energies. The situation is different for antikaons where in-medium effects strongly enhances their production rates. We also see strong in-medium modifications of the annihilation processes of antikaons and Lambda's which might be visible in flow measurements. At high density, we predict that the threshold energy for antikaon and Lambda production and annihilation become equal leading to similar numbers of antikaons and Lambda's in the dense zone of a relativistic heavy ion collision.Comment: 32 pages, 5 Postscript figures, uses Revtex and epsf.st

Geschichte der schweizerischen Eidgenossenschaft. : Eine Darstellung /

Printed in double columns.Mode of access: Internet

Active caspase 3 and DNA fragmentation as markers for apoptotic cell death in primary and metastatic liver tumours

AIMS: The induction of tumour cell death by apoptosis is a major goal of cancer therapy and the in situ detection of apoptosis in tumour tissue has become an important diagnostic parameter. Different apoptosis detection methods assess distinct biochemical processes in the dying cell. Thus, their direct comparison is mandatory to evaluate their diagnostic value. The aim of this study was to compare the immunohistochemical detection of active caspase 3 and single-stranded DNA in primary and metastatic liver tumours as markers of apoptotic cell death. METHODS: We studied detection of active caspase 3 and single-stranded DNA in 20 primary hepatocellular carcinomas (HCC) and 20 liver metastases from colorectal carcinomas (CRC) using immunohistochemistry on paraffin sections. RESULTS: Our results reveal that both methods are suitable and sensitive techniques for the in situ detection of apoptosis, however, they also demonstrate that immunohistochemistry for active caspase 3 and single-stranded DNA have differential sensitivities in HCC and CRC. CONCLUSION: The sensitivity of apoptosis detection using immunohistochemistry for active caspase 3 and single-stranded DNA may be tumour cell type dependent

3D printing of robotic soft actuators with programmable bioinspired architectures

Soft actuation allows robots to interact safely with humans, other machines, and their surroundings. Full exploitation of the potential of soft actuators has, however, been hindered by the lack of simple manufacturing routes to generate multimaterial parts with intricate shapes and architectures. Here, we report a 3D printing platform for the seamless digital fabrication of pneumatic silicone actuators exhibiting programmable bioinspired architectures and motions. The actuators comprise an elastomeric body whose surface is decorated with reinforcing stripes at a well-defined lead angle. Similar to the fibrous architectures found in muscular hydrostats, the lead angle can be altered to achieve elongation, contraction, or twisting motions. Using a quantitative model based on lamination theory, we establish design principles for the digital fabrication of silicone-based soft actuators whose functional response is programmed within the material's properties and architecture. Exploring such programmability enables 3D printing of a broad range of soft morphing structures.ISSN:2041-172