Rapid tissue regeneration induced by intracellular ATP delivery—A preliminary mechanistic study - Fig 10

<p><b>A schematic illustration of possible mechanisms that could explain the rapid tissue regeneration seen in response to intracellular ATP delivery</b>: 1) treatment of ATP-vesicles causes massive macrophage accumulation in the wound wall and cavity; 2) the treatment also cause macrophage in situ proliferation; 3) the supplied energy supports cell survival and function in the wound cavity even though neovascularization has not completed; 4) the activated macrophages produce collagen directly; 5) neovascularization is enhanced, which directly transforms the early cell mass into the extracellular matrix; and 6) reepithelialization is enhanced on the basis of rapidly formed granulation tissues. In the control wounds, cell migration and accumulation cannot be achieved because there is no energy supply in the wound cavity.</p