Treatment of failed articular cartilage reconstructive procedures of the knee: A systematic review

Background: Symptomatic articular cartilage lesions of the knee are common and are being treated surgically with increasing frequency. While many studies have reported outcomes following a variety of cartilage restoration procedures, few have investigated outcomes of revision surgery after a failed attempt at cartilage repair or reconstruction. Purpose: To investigate outcomes of revision cartilage restoration procedures for symptomatic articular cartilage lesions of the knee following a previously failed cartilage reconstructive procedure. Study Design: Systematic review; Level of evidence, 4. Methods: A literature search was performed by use of the PubMed, EMBASE, and MEDLINE/Ovid databases for relevant articles published between 1975 and 2017 that evaluated patients undergoing revision cartilage restoration procedure(s) and reported outcomes using validated outcome measures. For studies meeting inclusion criteria, relevant information was extracted. Results: Ten studies met the inclusion criteria. Lesions most commonly occurred in the medial femoral condyle (MFC) (52.8%), with marrow stimulation techniques (MST) the index procedure most frequently performed (70.7%). Three studies demonstrated inferior outcomes of autologous chondrocyte implantation (ACI) following a previous failed cartilage procedure compared with primary ACI. One study comparing osteochondral allograft (OCA) transplant following failed microfracture (MFX) with primary OCA transplant demonstrated similar clinical outcomes and graft survival at midterm follow-up. No studies reported outcomes following osteochondral autograft transfer (OAT) or newer techniques. Conclusion: This systematic review of the literature reporting outcomes following revision articular cartilage restoration procedures (most commonly involving the MFC) demonstrated a high proportion of patients who underwent prior MST. Evidence is sufficient to suggest that caution should be taken in performing ACI in the setting of prior MST, likely secondary to subchondral bone compromise. OCA appears to be a good revision treatment option even if the subchondral bone has been violated from prior surgery or fracture. </jats:sec

An Ecological Assessment of Property and Violent Crime Rates Across a Latino Urban Landscape: The Role of Social Disorganization and Institutional Anomie Theory

The present research put forth an integrated theoretical framework aimed at providing a more holistic community- level approach explaining crime across a heavily populated Latino city. Guided by social disorganization and institutional anomie theory, this study used several data sources and OLS regression techniques to examine the impact of social disorganization, economic and noneconomic institutional characteristics on rates of property and violent crime across 1,016 census block groups in San Antonio, Texas. While several findings emerged, interactions between alcohol density and concentrated disadvantage were significant and positively associated with property and violent crime. Interactions between welfare generosity and concentrated disadvantage were significant and negatively associated with the outcomes

Bad moon on the rise? Lunar cycles and incidents of crime

Popular cultures in Western societies have long espoused the notion that phases of the moon influence human behavior. In particular, there is a common belief the full moon increases incidents of aberrant, deviant, and criminal behavior. Using police, astronomical, and weather data from a major southwestern American city, this study assessed whether lunar cycles related with rates of reported crime. The findings fail to support popular lore, which has suggested that lunar phase influenced the volume of crime reported to the police. Future research directions examining qualitative rather than quantitative aspects of this problem may yield further inform the understanding of whether lunar cycles appreciably influence demands for policing services

Constructing Crime: Neighborhood Characteristics and Police Recording Behavior

It has long been acknowledged that police officers have substantial levels of discretion in their day-to-day activities. There is a well developed body of literature that considers how this discretion is exercised across a broad array of situations including the decision to arrest, use force, and grant citizen requests for official action. Using both social disorganization and conflict theories as conceptual models, the purpose of this study was to determine if neighborhood characteristics affect police reporting behavior across a wide cross-section of reported call types. The findings indicated that reporting behavior widely varies across crime types with a greater percentage of more serious crimes translated into official crime. Neighborhood characteristics did affect reporting practices, but surprisingly only for more serious forms of disorder where discretion was perceived to be less. The findings lent support for both social disorganization and conflict theories. Theoretical implications are discussed

A Tale of Three Cities: Crime and Displacement after Hurricane Katrina

When Hurricane Katrina struck New Orleans in August 2005, it greatly disrupted both the physical and social structures of that community. One consequence of the hurricane was the displacement of large numbers of New Orleans residents to other cities, including Houston, San Antonio, and Phoenix. There has been media speculation that such a grand-scale population displacement led to increased crime in communities that were recipient of large numbers of displaced New Orleans residents. This study was a case study of three cities with somewhat different experiences with Katrina\u27s diaspora. Time series analysis was used to examine the pre- and post-Katrina trends in six Part I offenses (murder, robbery, aggravated assault, rape, burglary, and auto theft) to assess any impact of such large-scale population shifts on crime in host communities. Contrary to much popular speculation, only modest effects were found on crime. Social disorganization theory was used to frame both the analysis and the interpretation of these result

Infinite spin limit of semiclassical string states

Motivated by recent works of Hofman and Maldacena and Dorey we consider a special infinite spin limit of semiclassical spinning string states in AdS5 x S5. We discuss examples of known folded and circular 2-spin string solutions and demonstrate explicitly that the 1-loop superstring correction to the classical expression for the energy vanishes in the limit when one of the spins is much larger that the other. We also give a general discussion of this limit at the level of integral equations describing finite gap solutions of the string sigma model and argue that the corresponding asymptotic form of the string and gauge Bethe equations is the same.Comment: 38 pages, 3 figures; v2: comments on derivation of bound states of magnons from discrete Bethe equations added in section 4 and appendix C, references added, Imperial-TP-AT-6-4, HUTP-06/A002

Generalized spacetimes defined by cubic forms and the minimal unitary realizations of their quasiconformal groups

We study the symmetries of generalized spacetimes and corresponding phase spaces defined by Jordan algebras of degree three. The generic Jordan family of formally real Jordan algebras of degree three describe extensions of the Minkowskian spacetimes by an extra "dilatonic" coordinate, whose rotation, Lorentz and conformal groups are SO(d-1), SO(d-1,1) XSO(1,1) and SO(d,2)XSO(2,1), respectively. The generalized spacetimes described by simple Jordan algebras of degree three correspond to extensions of Minkowskian spacetimes in the critical dimensions (d=3,4,6,10) by a dilatonic and extra (2,4,8,16) commuting spinorial coordinates, respectively. The Freudenthal triple systems defined over these Jordan algebras describe conformally covariant phase spaces. Following hep-th/0008063, we give a unified geometric realization of the quasiconformal groups that act on their conformal phase spaces extended by an extra "cocycle" coordinate. For the generic Jordan family the quasiconformal groups are SO(d+2,4), whose minimal unitary realizations are given. The minimal unitary representations of the quasiconformal groups F_4(4), E_6(2), E_7(-5) and E_8(-24) of the simple Jordan family were given in our earlier work hep-th/0409272.Comment: A typo in equation (37) corrected and missing titles of some references added. Version to be published in JHEP. 38 pages, latex fil

Changes in Body Mass Index and Atherosclerotic Disease Risk Score After Switching From Tenofovir Disoproxil Fumarate to Tenofovir Alafenamide.

Background: Switching from tenofovir disoproxil fumarate (TDF) to tenofovir alafenamide (TAF)-containing antiretroviral therapy (ART) can improve renal function and bone mineral density in people with human immunodeficiency virus (PWH). The switch can also negatively influence cholesterol, but changes in body mass index (BMI) and atherosclerotic cardiovascular disease (ASCVD) risk are unknown. Methods: This retrospective observational study evaluated BMI and ASCVD risk score changes in virologically suppressed PWH who switched from TDF to TAF without switching other ART regimen components. Adults on TDF for ≥1 year with 2 consecutive HIV ribonucleic acid values/mL before a TAF switch were included. Body weight, BMI, cholesterol, and ASCVD risk score were collected for the year before and after the switch. Pre- and postswitch values were compared with the Wilcoxon signed-rank test. Changes in BMI and ASCVD scores were modeled using generalized estimating equations regression. Results: One hundred ten patients were included. In unadjusted analyses, there were significant increases in weight, BMI, total cholesterol, LDL, HDL, and ASCVD risk score in the year after switching from TDF to TAF (each P ≤ .01). In regression models, switching from TDF to TAF was associated with a 0.45 kg/m2 increase in BMI (95% confidence interval [CI], 0.14-0.76) and a 13% increase in ASCVD risk score (95% CI, 4%-23%). Conclusions: We observed significant BMI and ASCVD score increases in PWH 1 year after switching from TDF to TAF. The mechanism of changes is unclear and requires additional study

Race, Slavery, and the Expression of Sexual Violence in Louisa Picquet, The Octoroon

Historically, victims of sexual violence have rarely left written accounts of their abuse, so while sexual violence has long been associated with slavery in the United States, historians have few accounts from formerly enslaved people who experienced it first-hand. Through a close reading of the narrative of Louisa Picquet, a survivor of sexual violence in Georgia and Louisiana, this article reflects on the recovery of evidence of sexual violence under slavery through amanuensis-recorded testimony, the unintended evidence of survival within the violent archive of female slavery, and the expression of “race” as an authorial device through which to demonstrate the multigenerational nature of sexual victimhood

Jet energy measurement with the ATLAS detector in proton-proton collisions at root s=7 TeV

The jet energy scale and its systematic uncertainty are determined for jets measured with the ATLAS detector at the LHC in proton-proton collision data at a centre-of-mass energy of √s = 7TeV corresponding to an integrated luminosity of 38 pb-1. Jets are reconstructed with the anti-kt algorithm with distance parameters R=0. 4 or R=0. 6. Jet energy and angle corrections are determined from Monte Carlo simulations to calibrate jets with transverse momenta pT≥20 GeV and pseudorapidities {pipe}η{pipe}<4. 5. The jet energy systematic uncertainty is estimated using the single isolated hadron response measured in situ and in test-beams, exploiting the transverse momentum balance between central and forward jets in events with dijet topologies and studying systematic variations in Monte Carlo simulations. The jet energy uncertainty is less than 2. 5 % in the central calorimeter region ({pipe}η{pipe}<0. 8) for jets with 60≤pT<800 GeV, and is maximally 14 % for pT<30 GeV in the most forward region 3. 2≤{pipe}η{pipe}<4. 5. The jet energy is validated for jet transverse momenta up to 1 TeV to the level of a few percent using several in situ techniques by comparing a well-known reference such as the recoiling photon pT, the sum of the transverse momenta of tracks associated to the jet, or a system of low-pT jets recoiling against a high-pT jet. More sophisticated jet calibration schemes are presented based on calorimeter cell energy density weighting or hadronic properties of jets, aiming for an improved jet energy resolution and a reduced flavour dependence of the jet response. The systematic uncertainty of the jet energy determined from a combination of in situ techniques is consistent with the one derived from single hadron response measurements over a wide kinematic range. The nominal corrections and uncertainties are derived for isolated jets in an inclusive sample of high-pT jets. Special cases such as event topologies with close-by jets, or selections of samples with an enhanced content of jets originating from light quarks, heavy quarks or gluons are also discussed and the corresponding uncertainties are determined. © 2013 CERN for the benefit of the ATLAS collaboration