Cosmic (super)string constraints from 21 cm radiation

We calculate the contribution of cosmic strings arising from a phase transition in the early universe, or cosmic superstrings arising from brane inflation, to the cosmic 21 cm power spectrum at redshifts z > 30. Future experiments can exploit this effect to constrain the cosmic string tension Gu and probe virtually the entire brane inflation model space allowed by current observations. Although current experiments with a collecting area of ~ 1 km^2 will not provide any useful constraints, future experiments with a collecting area of 10^4-10^6 km^2 covering the cleanest 10% of the sky can in principle constrain cosmic strings with tension Gu > 10^(-10) to 10^(-12) (superstring/phase transition mass scale >10^13 GeV).Comment: Accepted for publication in PR

Proteogenetic drug response profiling elucidates targetable vulnerabilities of myelofibrosis

Myelofibrosis is a hematopoietic stem cell disorder belonging to the myeloproliferative neoplasms. Myelofibrosis patients frequently carry driver mutations in either JAK2 or Calreticulin (CALR) and have limited therapeutic options. Here, we integrate ex vivo drug response and proteotype analyses across myelofibrosis patient cohorts to discover targetable vulnerabilities and associated therapeutic strategies. Drug sensitivities of mutated and progenitor cells were measured in patient blood using high-content imaging and single-cell deep learning-based analyses. Integration with matched molecular profiling revealed three targetable vulnerabilities. First, CALR mutations drive BET and HDAC inhibitor sensitivity, particularly in the absence of high Ras pathway protein levels. Second, an MCM complex-high proliferative signature corresponds to advanced disease and sensitivity to drugs targeting pro-survival signaling and DNA replication. Third, homozygous CALR mutations result in high endoplasmic reticulum (ER) stress, responding to ER stressors and unfolded protein response inhibition. Overall, our integrated analyses provide a molecularly motivated roadmap for individualized myelofibrosis patient treatment

Ciliary body length revisited by anterior segment optical coherence tomography: implications for safe access to the pars plana for intravitreal injections.

PURPOSE To investigate the dependence of the ciliary body length (CBL) on the axial length (AL) and to draw conclusions on implications regarding safe pars plana access for intravitreal injections and vitreoretinal surgery. METHODS A total of 200 individuals (mean age 42 years, SD ± 15.4) were enrolled in the study. Objective refraction and AL were obtained. Spherical equivalent (SE) was calculated. Anterior segment optical coherence tomography (ASOCT) was used to image and measure the CBL. RESULTS The mean SE was - 1.64 diopters (SD ± 3.15, range - 14.5 to + 9 diopters) and the mean AL was 24.19 mm (SD ± 1.65, range 19.8-32.2 mm). There was a significant correlation between SE and AL (r2 = 0.62, p  25 mm). The mean CBL in the normal AL group was 3311 μm (SD ± 427), in the short AL group 2936 μm (SD ± 335) and in the long AL group 3715 μm (SD ± 365), and differed significantly (p < 0.0001) when compared. CONCLUSION For interventions requiring pars plana access (as an intravitreal injection or vitreoretinal surgery), an incision distance of 3.5-4.0 mm posterior to the limbus is recommended. In our research, however, a difference of 0.77 mm in mean CBL between the group with short AL and the group with long AL is demonstrated, implying that the mean CBL in very short and very long eyes differs significantly. These findings suggest that the AL should be taken into account for pars plana access and that it would be advisable to prefer the shorter or longer recommended distance (3.5 and 4.0 mm, respectively) from the limbus, which correlates with the AL. If AL is > 25 mm, a distance of 4.0 mm from the limbus should be chosen; and if AL is < 22.5 mm, a distance of 3.5 mm seems adequate. TRIAL REGISTRATION NUMBER AND DATE NCT00564291, 27 Nov 2007

Adaptive capacity and flexibility of the Neanderthals at Heidenschmiede (Swabian Jura) with regard to core reduction strategies

The branched reduction system at the Heidenschmiede described here is hitherto exceptional for the Middle Paleolithic of the Swabian Jura. By means of refits and supporting objects, we are able to describe a superordinate reduction system that combines several individual reduction concepts, such as Levallois and blade production, within one volume. In the Middle Paleolithic of the Swabian Jura, blade technology has thus far played a rather minor role. On the one hand, it is possible to split a selected volume (nodule) into three parts, which are reduced separately according to individual concepts. On the other hand, it is also possible to reduce parts of a volume with one concept first and then with another. The hypothetical reduction system can be branched or linear, thus emphasizing the technological flexibility in core reduction, which requires a high degree of cognitive skills of three-dimensional imagination

The origin of chert in the Aurignacian of Vogelherd Cave investigated by infrared spectroscopy

The analyses of raw material provenance offers the possibility of tracing short and long-distance raw material transport. So far, most studies of raw material of flint and chert in Europe have been based on macroscopic analyses. We apply infrared spectroscopy to Aurignacian assemblages from Vogelherd cave and to the Magdalenian site Randecker Maar in southwestern Germany. We compare raw material samples from three chert-bearing areas in Germany with archaeological samples from Vogelherd. Our results show that infrared spectroscopy can distinguish between different raw materials. Our archaeological samples from Vogelherd correspond to the sampled geological cherts in terms of their spectral signature. Our comparison of reference samples and archaeological samples highlights problems in commonly used macroscopic identifications of chert raw materials

New finds from Hohle Fels Cave in the Swabian Jura require a reassessment of cultural variability during the late Middle Paleolithic in Central Europe

peer reviewe

Tiefengrundwasser – Vorkommen, Nutzungspotenzial und Schutzwürdigkeit

Tiefengrundwasser findet sich in allen grosstektonischen Einheiten der Schweiz. Die bekannten, teilweise genutzten Vorkommen von Tiefengrundwas-ser und insbesondere die chemische Zusammensetzung dieser Wässer wird für die verschiedenen Einheiten aufgezeigt. Im Hinblick auf mögliche Nutzungskon-flikte werden die gesetzlichen Grundlagen und Massnahmen zum Schutz dieser Ressource diskutiert