Engagement in course development by employers not traditionally involved in Higher Education: student and employer perceptions of its impact

The aim of the research was to improving understanding of employers' engagement in Higher Education and identify its impact. In particular, the review looked at engagement by employers that have not traditionally been involved in Higher Education. The research involved a systematic review that identified research in the UK and synthesised the eight most robust research studies

Report to HEFCE on student engagement

This study, commissioned by the Higher Education Funding Council for England (HEFCE), explored the extent and nature of student engagement in the higher education sector in England. The study was concerned with institutional and student union processes and practices – such as those relating to student representation and student feedback – which seek to inform and enhance the collective student learning experience, as distinct from specific teaching, learning and assessment activities that are designed to enhance individual students’ engagement with their own learning. The study found that institutions view student engagement as central to enhancing the student experience, but the emphasis seems to be placed on viewing students as consumers. For student unions, the emphasis is on viewing them as partners in a learning community. The latter notion seems to be stronger in certain subject areas (for example, Art and Design and Performing Arts) than others. The majority of HEIs and FE colleges rate their student engagement processes – comprising a basic model of student feedback questionnaires and student representation systems – as reasonably or very effective; student unions are less likely to do so. Detailed discussions with staff and students within a diverse range of HE providers showed that actual practices vary between and within institutions and that their effectiveness could be improved. Higher education institutions, student unions and further education colleges with significant higher education provision were surveyed to establish a baseline measure of the nature and extent of student engagement processes. Further exploration of institutions’ formal and informal processes and their effectiveness was undertaken through fieldwork with a number of higher education providers and student unions

Towards a strategy for workplace learning: Report to HEFCE by CHERI and KPMG

The study, undertaken between March and November 2005 aimed to inform HEFCE thinking on developing a strategy for workplace learning by: exploring the nature, purposes and outcomes of workplace learning; considering workplace learning within the broader relationships between the worlds of work and learning; exploring emerging changes in higher education which may impact on workplace learning in the future; identifying structural issues that currently enable or inhibit workplace learning, and identify future opportunities

Структурно-типологическое сравнение русской народной сказки с советской

The term “Soviet folk tale” refers to a specific folk genre that developed in the Soviet Union on the basis of the centuries-old traditions of the Russian folk tale: it was an attempt to use an existing cultural model for ideological and political purposes. The typological-structural study of the analogies and differences between the poetic features of the traditional folk tale and the Soviet folk tale at a number of levels (sintagmatic semantic narrative, typological and verb-subject) and in a number of genres (magic realistic and allegorical) leads to the identification of methods and procedures necessary for the mythification of reality and of the Soviet hero

Strukturno-tipologičeskoe sravnenie russkoj narodnoj skazki s sovetskoj

The term “Soviet folk tale” refers to a specific folk genre that developed in the Soviet Union on the basis of the centuries-old traditions of the Russian folk tale: it was an attempt to use an existing cultural model for ideological and political purposes. The typological-structural study of the analogies and differences between the poetic features of the traditional folk tale and the Soviet folk tale at a number of levels (sintagmatic semantic narrative, typological and verb-subject) and in a number of genres (magic realistic and allegorical) leads to the identification of methods and procedures necessary for the mythification of reality and of the Soviet hero.Università degli Studi di Trieste - Scuola Superiore di Lingue Moderne per Interpreti e Traduttor

Discovery of ligands for TRIM58, a novel tissue selective E3 ligase

Redirecting E3 ligases to neo-substrates leading to their proteasomal disassembly, known as targeted protein degradation (TPD), has emerged as a promising alternative to traditional, occupancy driven pharmacology. Although the field has expanded tremendously over the last years, the choice of E3 ligases remains limited, with an almost exclusive focus on CRBN and VHL. Here, we report the discovery of novel ligands to the PRY-SPRY domain of TRIM58, a RING ligase that is specifically expressed in erythroid precursor cells. A DSF screen, followed by validation using additional biophysical methods, led to the identification of the TRIM58 ligand TRIM-473. A basic SAR around the chemotype was established by utilizing a competitive binding assay employing a short FP pep-tide probe derived from an endogenous TRIM58 substrate. The X-ray co-crystal structure of TRIM58 in complex with TRIM-473 gave insights to the binding mode and potential exit vectors for bifunctional degrader design