Resilient Drone Mission Management and Route Optimization in Drone Delivery Context

The last two decades were characterized by a rapidly increasing of innovative solutions in the microelectronic field, having therefore a significant impact on a huge set of applicative scenarios. This aspect allows the development and improvement of new solutions, giving the possibility of growth and development of new markets, such as the drones ones. Actually, in the unmanned field we have seen an exponential growth of the market, given not only from the increased computing capabilities, but also by a more efficient developed hardware, thus leading to the definition of innovative uses, service paradigms and applications. The latter span in several different areas, from agriculture monitoring to society's services including the Package Delivery which immediately plays a strategic role in the modern society. These types of applications took place mainly in an urban environment, highlighting therefore new rules, needs and management system in order to accommodate the mission's achievement guaranteeing at the same time a high degree of resilience, citizen safety and risks minimization. Furthermore, to assist these types of operations, T-DROMES, a RPAS (Remotely Piloted Aerial Systems) fleet and mission management solution, was developed allowing to scale-up the use of drones in complex operations from a geographical and mission point of view, in different applicative scenarios. The paper aims therefore to presents the tools capabilities and how the developed architecture is able to manage the entire mission for any context scenario and how the developed platforms and tools can be a valid framework for developing new operative working models

Liver involvement in a large cohort of patients with hereditary hemorrhagic telangiectasia: Echo-color-Doppler vs multislice computed tomography study

Background/Aims: Hepatic arterio-venous malformations (HAVMs) have been found in 74% of hereditary hemorrhagic telangiectasia (HHT) patients with multislice CT (MSCT). This single-blind study aimed to compare the diagnostic accuracy of echo-color-Doppler with MSCT and identify the most sensitive ultrasound criteria indicating hepatic shunts. Methods: One hundred and fifty-three HHT patients were systematically screened for HAVMs by biological tests, abdominal MSCT and echo-color-Doppler. Twenty-five normal subjects and 15 cirrhotic patients were also included as control groups. Both intrahepatic ("color spots" and hypervascularization) and extrahepatic parameters (diameter, flow velocity and tortuosity of hepatic artery and diameter and flow velocity of portal/hepatic vein) were utilized. "Color-spots" are defined as subcapsular vascular spots with a high-velocity arterial blood flow and low resistivity index and can identify extremely small HAVMs. Results: CT was positive in 128/153 (84%) patients and Doppler color spots were found in 131/153 (86%) patients. The sensitivity, specificity and diagnostic accuracy of "color spots" compared to MSCT were 95.3%, 68.0% and 91.8%, respectively. The "color-spot" showed a greater correlation to CT (V-index = 0.655; p < 0.0001) than extrahepatic criteria (V = 0.317). In 20/29 (69%) subjects, echo-color-Doppler, confirmed by CT, identified the third criterion for definite HHT diagnosis. Conclusions: Intrahepatic criteria was superior to extrahepatic criteria for identification of HAVMs. A new Doppler parameter ("color-spots") with an optimal accuracy for detecting HAVMs is proposed for easy periodic screening of HHT patients. (C) 2008 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved

Characterization of the rs2802292 SNP identifies FOXO3A as a modifier locus predicting cancer risk in patients with PJS and PHTS hamartomatous polyposis syndromes

Background: Hamartomatous polyposis syndromes (HPS) are inherited conditions associated with high cancer risk. They include the Peutz-Jeghers and the PTEN hamartoma tumor syndromes, which are caused by mutations in the LKB1 and PTEN genes, respectively. Estimation of cancer risk is crucial in order to optimize surveillance, but no prognostic markers are currently available for these conditions. Our study relies on a 'signal transduction' hypothesis based on the crosstalk between LKB1/AMPK and PI3K/PTEN/Akt signaling at the level of the tumor suppressor protein FoxO3A. Interestingly, the FOXO3A rs2802292 G-allele was shown to be associated with longevity, reduced risk of aging-related diseases and increased expression of FoxO3A mRNA. Methods: We typed rs2802292 in 150 HPS unrelated patients and characterized the expression of FoxO3A by quantitative PCR and immunoblot analysis in human intestinal cell lines. Results: We found a significantly higher risk for malignancies in females and TT genotype carriers compared to patients having at least one G-allele. Subgroup analysis for each HPS syndrome revealed a G-allele-associated beneficial effect on cancer risk occurring mainly in males. Molecular characterization of human intestinal cell lines showed that the G-allele significantly correlated with increased basal expression of FoxO3A mRNA and protein. Conclusion: Our results suggest an inverse correlation between the protective allele (G) copy number and cancer risk, and might be useful to optimize surveillance in HPS patients. Further investigations are needed to confirm our hypothesis and to ascertain whether differences in therapeutic response exist across genotypes