Exploring antecedents of innovations for small- and medium-sized enterprises' environmental sustainability: An interpretative framework

The need to pursue sustainable development has become a central topic in Western countries due to citizens' greater sensitivity to improving environmental and social conditions. Companies can reach this objective more easily through green innovations, which are now considered a strategic opportunity that simultaneously allows for adherence to sustainable development criteria and the pursuit of competitive advantages. Scholars have identified the determinants that encourage companies to adopt green innovations, but the outcomes of their investigations thus far have often been ambiguous and contradictory. Our paper proposes an interpretative framework for addressing such inconsistencies. Using the partial least squares structural equation modelling (PLS-SEM) methodology, we validate this framework on a sample of small- and medium-sized enterprises (SMEs) and show that SMEs' choices are influenced by cultural elements and stimulated by the prospect of obtaining economic advantages over competitors. SMEs also pay close attention to stakeholder solicitations, while public administration does not affect their eco-innovating choices. The results have policy implications for executives and insiders

3D CAMERAS ACQUISITIONS FOR THE DOCUMENTATION OF CULTURAL HERITAGE

Abstract. Photography has always been considered as a valid tool to acquire information about reality. Nowadays, its versatility, together with the development of new techniques and technologies, allows to use it in different fields of application. Particularly, in the digitization of built heritage, photography not only enables to understand and document historical and architectural artifacts but also to acquire morphological and geometrical data about them with automated digital photogrammetry. Nowadays, photogrammetry enables many tools to give virtual casts of reality by showing it in the way of point cloud. Although they can have metric reliability and visual quality, traditional instruments &amp;ndash; such as monoscopic cameras &amp;ndash; involve a careful planning of the campaign phase and a long acquisition and processing time. On the contrary, the most recent ones, based on the integration of different sensors and cameras, try to reduce the gap between time and results. The latter include some systems of indoor mapping who, thanks to 360&amp;deg; acquisitions and SLAM technology, reconstruct the original scene in real time in great detail and with a photorealistic rendering. This study is aimed at reporting a research evaluating metric reliability and the level of survey detail with a Matterport Pro2 3D motorized rotating camera, equipped with SLAM technology, whose results have been compared with point clouds obtained by image-based and range-based processes.</p

Cancer management during COVID-19 pandemic: is immune checkpoint inhibitors-based immunotherapy harmful or beneficial?

The coronavirus disease 2019 (COVID-19) is currently representing a global health threat especially for fragile individuals, such as cancer patients. It was demonstrated that cancer patients have an increased risk of developing a worse symptomatology upon severe acute respiratory syndrome associated coronavirus-2 (SARS-CoV-2) infection, often leading to hospitalization and intensive care. The consequences of this pandemic for oncology are really heavy, as the entire healthcare system got reorganized. Both oncologists and cancer patients are experiencing rescheduling of treatments and disruptions of appointments with a concurrent surge of fear and stress. In this review all the up-to-date findings, concerning the association between COVID-19 and cancer, are reported. A remaining very debated question regards the use of an innovative class of anti-cancer molecules, the immune checkpoint inhibitors (ICIs), given their modulating effects on the immune system. For that reason, administration of ICIs to cancer patients represents a question mark during this pandemic, as its correlation with COVID-19-associated risks is still under investigation. Based on the mechanisms of action of ICIs and the current evidence, we suggest that ICIs not only can be safely administered to cancer patients, but they might even be beneficial in COVID-19-positive cancer patients, by exerting an immune-stimulating action

Effect of sunlight exposure on anthocyanin and non-anthocyanin phenolic levels in pomegranate juices by high resolution mass spectrometry approach

Quali-quantitative analyses of anthocyanins and non-anthocyanin phenolic compounds performed with the use of liquid chromatography coupled with high resolution mass spectrometry, were evaluated in juice of pomegranate fruits (‘Dente di Cavallo’), in relation to different light exposures (North, South, West and East). A total of 16 compounds were identified, including phenolic acids, flavonoids, hydrolysable tannins, and anthocyanins, known for their health-promoting effects. Striking differences were observed about the total phenolic content, which was high in juices from fruits with east- and north-facing position, while it was lower in juices facing south. The greatest contents of total flavonoids and anthocyanins were recorded in fruit juices with southern exposure; however, there are no great differences in the content in phenolic acids. Tannins were mainly synthesized in fruit juices with West exposure. The results showed that the position within the tree had no significant effects on color juice, however, it significantly (p &lt; 0.05) affected data on fruit weight, soluble sugars and juice yield. Remarkable synergies existed among polyphenols and phytochemicals in pomegranate juice, but collecting fruits with different solar exposure could enhance different health benefits, i.e., the juices with higher polyphenols content could have more anticancer effect or those with higher tannins content could have more antimicrobial effect

Massive 3+1 Aharonov-Bohm fermions in an MIT cylinder

We study the effect of a background flux string on the vacuum energy of massive Dirac fermions in 3+1 dimensions confined to a finite spatial region through MIT boundary conditions. We treat two admissible self-adjoint extensions of the Hamiltonian. The external sector is also studied and unambiguous results for the Casimir energy of massive fermions in the whole space are obtained.Comment: 12 pages, 5 figures, LaTe

Immune-checkpoint inhibitors from cancer to COVID‑19: A promising avenue for the treatment of patients with COVID‑19

The severe acute respiratory syndrome associated coronavirus‑2 (SARS‑CoV‑2) poses a threat to human life worldwide. Since early March, 2020, coronavirus disease 2019 (COVID‑19), characterized by an acute and often severe form of pneumonia, has been declared a pandemic. This has led to a boom in biomedical research studies at all stages of the pipeline, from the in vitro to the clinical phase. In line with this global effort, known drugs, currently used for the treatment of other pathologies, including antivirals, immunomodulating compounds and antibodies, are currently used off‑label for the treatment of COVID‑19, in association with the supportive standard care. Yet, no effective treatments have been identified. A new hope stems from medical oncology and relies on the use of immune‑checkpoint inhibitors (ICIs). In particular, amongst the ICIs, antibodies able to block the programmed death‑1 (PD‑1)/PD ligand-1 (PD‑L1) pathway have revealed a hidden potential. In fact, patients with severe and critical COVID‑19, even prior to the appearance of acute respiratory distress syndrome, exhibit lymphocytopenia and suffer from T‑cell exhaustion, which may lead to viral sepsis and an increased mortality rate. It has been observed that cancer patients, who usually are immunocompromised, may restore their anti‑tumoral immune response when treated with ICIs. Moreover, viral-infected mice and humans, exhibit a T‑cell exhaustion, which is also observed following SARS‑CoV‑2 infection. Importantly, when treated with anti‑PD‑1 and anti‑PD‑L1 antibodies, they restore their T‑cell competence and efficiently counteract the viral infection. Based on these observations, four clinical trials are currently open, to examine the efficacy of anti‑PD‑1 antibody administration to both cancer and non‑cancer individuals affected by COVID‑19. The results may prove the hypothesis that restoring exhausted T‑cells may be a winning strategy to beat SARS‑CoV‑2 infection