The synthesis of silica-coated magnetic nanoparticles and using as adsorbent

In this work, the silica-coated magnetic field-sensitive iron nanoparticles (Si-gamma Fe2O3) were successfully prepared by sol-gel method and used as the adsorbent in the adsorption of methylene blue. The adsorption capacity was evaluated. Batch adsorption experiments were performed as a function of contact time, initial dye concentration (5-20 mg/L), solution pH (4.0-9.6) and temperature (298-328 K). The structure and the morphology of this material were characterized by the Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM), transmission electron microscopy (TEM) and X-ray diffraction (XRD). The adsorption kinetic studies were achieved using pseudo-first order, and pseudo-second order kinetic models. The adsorption kinetic of methylene blue on Si-gamma Fe2O3 is consistent with the pseudo-second order kinetic model. Thermodynamic parameters such as Gibbs free energy (Delta GA degrees), enthalpy (Delta HA degrees) and entropy (Delta SA degrees) changes were evaluated and the results indicated that adsorption process was endothermic and spontaneous. The equilibrium isotherms for the adsorption of methylene blue on the adsorbent were described by the Freundlich and Langmuir isotherm models

Paracetamol hypersensitivity in children

Congress of the European-Academy-of-Allergy-and-Clinical-Immunology (EAACI) -- MAY 26-30, 2018 -- Munich, GERMANYWOS: 000441690401003…European Acad Allergy & Clin Immuno

Behind the scene: Paracetamol hypersensitivity in children.

Background Paracetamol, a non-steroidal anti-inflammatory drug, is commonly being used for fever and pain relief worldwide. The aim of this study was to evaluate children with a suspected history of paracetamol hypersensitivity. Methods Sixty patients who were referred to our clinic in between January 2015 and December 2018 with a suspected history of paracetamol hypersensitivity were included. Reactions were classified according to the European Network for Drug Allergy (ENDA)/Global Allergy and Asthma European Network classification and European Academy of Allergy and Clinical Immunology (EAACI)/ENDA Position Paper. Diagnoses were confirmed by skin tests and oral challenge tests (OCTs). In those with verified paracetamol hypersensitivity, an OCT with a strong COX-1 inhibitor was performed to classify the type of the reaction to refer as either selective or cross-intolerance hypersensitivity. A subsequent OCT with a selective COX-2 inhibitor was performed in those cross-intolerant patients to find out a safe alternative drug. Results Sixty OCTs with paracetamol were performed to patients with a median age of 8.5 years, and hypersensitivity to paracetamol was verified in 8 patients. Four children were classified as selective responders, and 3 were classified as cross-intolerant after OCT with a COX-1 inhibitor. Overall, skin test positivity for paracetamol was detected in only one patient, in whom OCT with paracetamol was negative. In all 3 cross-intolerant patients, a safe alternative non-steroidal anti-inflammatory drug was identified after an OCT with a selective COX-2 inhibitor. Conclusion OCT stands as the gold-standard procedure in verifying the diagnosis of patients with paracetamol-induced drug hypersensitivity, as well as, in defining the type of reactions and finding out safe alternative drugs