28 research outputs found
FRA SANKT OLAV TIL MARTIN LUTHER. Foredrag fremlagt ved det tredie nordiske symposion for ikonografiske studier, BÃ¥rdshaug, den 21.-24. august 1972. red. Martin Blindheim. Universitetets Oldsaksamling, Oslo, 1975
LISE GOTFREDSEN: RÃ…STED KIRKE. SPIL OG BILLEDE. 87 s., ill. Poul Pedersen fot. Akademisk forlag 1975
Heat Resistance Mediated by a New Plasmid Encoded Clp ATPase, ClpK, as a Possible Novel Mechanism for Nosocomial Persistence of Klebsiella pneumoniae
Klebsiella pneumoniae is an important opportunistic pathogen and a frequent cause of nosocomial infections. We have characterized a K. pneumoniae strain responsible for a series of critical infections in an intensive care unit over a two-year period. The strain was found to be remarkably thermotolerant providing a conceivable explanation of its persistence in the hospital environment. This marked phenotype is mediated by a novel type of Clp ATPase, designated ClpK. The clpK gene is encoded by a conjugative plasmid and we find that the clpK gene alone renders an otherwise sensitive E. coli strain resistant to lethal heat shock. Furthermore, one third of a collection of nosocomial K. pneumoniae isolates carry clpK and exhibit a heat resistant phenotype. The discovery of ClpK as a plasmid encoded factor and its profound impact on thermal stress survival sheds new light on the biological relevance of Clp ATPases in acquired environmental fitness and highlights the challenges of mobile genetic elements in fighting nosocomial infections