1 research outputs found
Photoelectrocatalysis of Cefotaxime Using Nanostructured TiO<sub>2</sub> Photoanode: Identification of the Degradation Products and Determination of the Toxicity Level
Nanostructured
TiO<sub>2</sub> thin films were fabricated via a
facile, economical, and energy-efficient microwave-assisted dip-coating
(MWDC) technique. Further, the resulting TiO<sub>2</sub> films were
characterized by means of X-ray diffraction, high-resolution transmission
electron microscopy, selected-area electron diffraction, Fourier transform
Raman spectroscopy, X-ray photoelectron spectroscopy, and photoluminescence
spectroscopy techniques for their phase structure, morphology, and
optical and surface properties. TiO<sub>2</sub>-mediated photoelectrocatalytic
degradation of the antibiotic cefotaxime (CFX) in an aqueous solution
was studied by varying the pH under UV illumination. The degradation
intermediates and possible reaction degradation path of CFX were analyzed
by electrospray ionization time-of-flight mass spectrometry (MS).
The MS spectra revealed that degradation of CFX occurs through β-lactum
corresponding to the cleavage of the cephem nucleus. Moreover, the
antibacterial activity of CFX prior to and after photoelectrocatalytic
degradation was carried out to analyze the toxicity against <i>Staphylococcus aureus</i> and salmonella typhi bacteria. Interestingly,
it was observed that the antibiotic activity was drastically inhibited
after photoelectrocatalytic degradation of the CFX solution. The photoelectrocatalytic
stability of a nanostructured TiO<sub>2</sub> electrode was evaluated
by recycling the degradation experiments. It was observed that there
was no significant decrease in the catalytic activity, indicating
potential applications of the TiO<sub>2</sub> electrode prepared by
the MWDC method