Peculiarities of microcirculatory reactions after subcutaneous implantation of polycaprolactone matrices mineralized by vaterite

The aim is to assess skin microcirculation changes arising during subcutaneous implantation of polycaprolactone scaffolds mineralized by vaterite. Material and Methods. The experiment was carried out on 30 albino rats divided into two groups: a negative control group and an experimental one. We implanted polycaprolactone scaffold with exhausted foreign protein subcutaneously into rats of the negative control group. We implanted polycaprolactone matrix mineralized by vaterite subcutaneously into the animals of the experimental group. Research methods include laser Doppler flowmetry and morphological examination of the tissues of the matrix implantation area. Results. Changes of skin microcirculation over the matrix allocation area correspond to the morphological pattern of tissue reactions. Biocompat-ibility disorders take the form of inflammation in the scaffold implantation area that is accompanied by stable perfusion rise associated with local bloodstream modulation changes. We did not observe inflammation signs in the surrounding scaffold tissues during implantation of polycaprolactone matrices mineralized by vaterite. Besides local microcircula-tory reactions possess a transient character disappearing completely by the 21st day after the implantation. Conclusion. Complex of the given functional and morphological studies allow us to ascertain high-grade biocompatibility of polycaprolactone matrices mineralized by vaterite thus giving rise to prospect of their use for tissue regeneration stimulation.</p

TRAILER: SCREEN COMMERCIAL OR MINIFILM? / ТРЕЙЛЕР: ЭКРАННАЯ РЕКЛАМА ИЛИ МИНИФИЛЬМ?

The authors examine the functions and construction of the trailer in the movie. The competition for viewers is growing, and the viewer needs guidance to select the most interesting and useful. The idea of the film before the preview is formed by advertising campaign where the most effective and informative means of promotion of the film is the trailer. It is a video consisting of the most spectacular film frames mounted in a single composition. Авторы рассматривают функции и конструкцию трейлера в кино. Конкуренция в борьбе за зрителя растет, и зритель нуждается в ориентирах, чтобы выбрать наиболее интересное и полезное. Представление о фильме до просмотра формируется рекламной кампанией, где наиболее эффективным и информативным средством продвижения фильма является трейлер. Он представляет собой видеоролик, состоящий из наиболее зрелищных кадров кинофильма, смонтированных в единую композицию