Targeted therapy for breast cancer prevention.

With a better understanding of the etiology of breast cancer, molecularly targeted drugs have been developed and are being testing for the treatment and prevention of breast cancer. Targeted drugs that inhibit the estrogen receptor (ER) or estrogen-activated pathways include the selective ER modulators (tamoxifen, raloxifene, and lasofoxifene) and aromatase inhibitors (AIs) (anastrozole, letrozole, and exemestane) have been tested in preclinical and clinical studies. Tamoxifen and raloxifene have been shown to reduce the risk of breast cancer and promising results of AIs in breast cancer trials, suggest that AIs might be even more effective in the prevention of ER-positive breast cancer. However, these agents only prevent ER-positive breast cancer. Therefore, current research is focused on identifying preventive therapies for other forms of breast cancer such as human epidermal growth factor receptor 2 (HER2)-positive and triple-negative breast cancer (TNBC, breast cancer that does express ER, progesterone receptor, or HER2). HER2-positive breast cancers are currently treated with anti-HER2 therapies including trastuzumab and lapatinib, and preclinical and clinical studies are now being conducted to test these drugs for the prevention of HER2-positive breast cancers. Several promising agents currently being tested in cancer prevention trials for the prevention of TNBC include poly(ADP-ribose) polymerase inhibitors, vitamin D, and rexinoids, both of which activate nuclear hormone receptors (the vitamin D and retinoid X receptors). This review discusses currently used breast cancer preventive drugs, and describes the progress of research striving to identify and develop more effective preventive agents for all forms of breast cancer

Influence of Independent Corrupt Practices and other Related Offences Commission on Female Civil Servants in Oyo State, Nigeria

This study examined the impact of ICPC’s ACTUs on female civil servants (FCS) in Oyo state, Nigeria. Corruption has been observed to be the bane of development to many nations of the world. Reports had it that civil servants contribute to corruption in t public offices through corrupt practices. To curb the menace, Nigerian government established ICPC Act, (2000) to educate and enlighten the public on the negative effect of corruption to national development. ICPC then instituted ACTUs in the civil service to monitor activities of civil servants, given the fact that corruption is said to be prevalent among female civil servants. The descriptive survey research design was adopted for the study. The purposive and proportional sampling techniques were adopted to select one thousand, one hundred and seventy six (1,176) respondents selected from the 22 core ministries and departments for the study. Data were analysed using percentage, pearson product moment correlation, multiple regression and content analyses. Findings revealed that, there is significant influence of ICPC’s ACTUs on the practice of accountability among female civil servants. Significant relationship existed between ICPC’s ACTUs and the practice of social responsiveness among female civil servants and also, a significant relationship existed between ICPC’s ACTUs and the respect for rule of law among female civil servants. From these findings, it is recommended that more ACTUs should be instituted in the MDAs. Civil servant, mostly female, should be accountable in the delivery of government services. There should be effective monitoring of ICPC’s ACTUs in the MDAs. Freedom of Information Act should be effectively put to practice. And the rule of law should be well respected. Keywords: Independent Corrupt Practices and Other Related Offences Commission, Corruption, Anti-corruption and Transparency Units, Female Civil Servants, Good Governance

Participatory Militias: An Analysis of an Armed Movement's Online Audience

Armed groups of civilians known as "self-defense forces" have ousted the powerful Knights Templar drug cartel from several towns in Michoacan. This militia uprising has unfolded on social media, particularly in the "VXM" ("Valor por Michoacan," Spanish for "Courage for Michoacan") Facebook page, gathering more than 170,000 fans. Previous work on the Drug War has documented the use of social media for real-time reports of violent clashes. However, VXM goes one step further by taking on a pro-militia propagandist role, engaging in two-way communication with its audience. This paper presents a descriptive analysis of VXM and its audience. We examined nine months of posts, from VXM's inception until May 2014, totaling 6,000 posts by VXM administrators and more than 108,000 comments from its audience. We describe the main conversation themes, post frequency and relationships with offline events and public figures. We also characterize the behavior of VXM's most active audience members. Our work illustrates VXM's online mobilization strategies, and how its audience takes part in defining the narrative of this armed conflict. We conclude by discussing possible applications of our findings for the design of future communication technologies.Comment: Participatory Militias: An Analysis of an Armed Movement's Online Audience. Saiph Savage, Andres Monroy-Hernandez. CSCW: ACM Conference on Computer-Supported Cooperative Work 201

Force Chains, Microelasticity and Macroelasticity

It has been claimed that quasistatic granular materials, as well as nanoscale materials, exhibit departures from elasticity even at small loadings. It is demonstrated, using 2D and 3D models with interparticle harmonic interactions, that such departures are expected at small scales [below O(100) particle diameters], at which continuum elasticity is invalid, and vanish at large scales. The models exhibit force chains on small scales, and force and stress distributions which agree with experimental findings. Effects of anisotropy, disorder and boundary conditions are discussed as well.Comment: 4 pages, 11 figures, RevTeX 4, revised and resubmitted to Phys. Rev. Let

Vertex operators and the geometry of moduli spaces of framed torsion-free sheaves

We define complexes of vector bundles on products of moduli spaces of framed rank r torsion-free sheaves on the complex projective plane. The top non-vanishing Chern classes of the cohomology of these complexes yield actions of the r-colored Heisenberg and Clifford algebras on the equivariant cohomology of the moduli spaces. In this way we obtain a geometric realization of the boson-fermion correspondence and related vertex operators.Comment: 36 pages; v2: Definition of geometric Heisenberg operators modified; v3: Minor typos correcte

Heavy Baryons and electromagnetic decays

In this talk I review the theory of electromagnetic decays of the ground state baryon multiplets with oneheavy quark, calculated using Heavy Hadron Chiral Perturbation Theory. The M1 and E2 amplitudes for (S^{*}-> S gamma), (S^{*} -> T gamma) and (S -> T gamma)are separately analyzed. All M1 transitions are calculated up to O(1/\Lambda_\chi^2). The E2 amplitudes contribute at the same order for (S^{*}-> S gamma), while for (S^{*} -> T gamma) they first appear at O(1/(m_Q \Lambda_\chi^2))and for (S -> T gamma) are completely negligible. Once the loop contributions is considered, relations among different decay amplitudes are derived. Furthermore, one can obtain an absolute prediction for the widths of Xi^{0'(*)}_c-> Xi^{0}_c gamma and Xi^{-'(*)}_b-> Xi^{-}_b gamma.Comment: Talk presented at 4^{th} International Conference Hyperons, Charm and Beauty Hadrons Conference, Valencia June 200

Lattice QCD study of a five-quark hadronic molecule

We compute the ground-state energies of a heavy-light K-Lambda like system as a function of the relative distance r of the hadrons. The heavy quarks, one in each hadron, are treated as static. Then, the energies give rise to an adiabatic potential Va(r) which we use to study the structure of the five-quark system. The simulation is based on an anisotropic and asymmetric lattice with Wilson fermions. Energies are extracted from spectral density functions obtained with the maximum entropy method. Our results are meant to give qualitative insight: Using the resulting adiabatic potential in a Schroedinger equation produces bound state wave functions which indicate that the ground state of the five-quark system resembles a hadronic molecule, whereas the first excited state, having a very small rms radius, is probably better described as a five-quark cluster, or a pentaquark. We hypothesize that an all light-quark pentaquark may not exist, but in the heavy-quark sector it might, albeit only as an excited state.Comment: 11 pages, 15 figures, 4 table