Reflecting on participatory research in environmental education : some issues for methodology

We reflect on methodological issues arising in two of our own research projects as a form of practice, as a way of engaging in a praxis of project research. The projects chosen for this purpose are themselves concerned with teacher education and curriculum development in environmental education: they include participatory &ldquo;reflective practice&rdquo; processes in exploring issues relating to formal education in schools and informal education in communities and are grounded in the specific contexts of developing countries.We discuss issues in participatory research such as:&bull; Whose research agenda gets to be explored?&bull; The importance of project partnerships&bull; Participants&rsquo; preconceptions about the nature of research&bull; What is &ldquo;rigor&rdquo; in participatory research in environmental education?&bull; The Colonialist Dilemma: Avoiding the &ldquo;package or perish&rdquo; mentality&bull; The Bigger Picture: Technocratic Rationality and Participatory Research.<br /

Note de synthèse. De l'interdisciplinarité scolaire à l'interdisciplinarité dans la formation à l'enseignement : un état de la question

Lenoir Yves, Sauve Lucie. Note de synthèse. De l'interdisciplinarité scolaire à l'interdisciplinarité dans la formation à l'enseignement : un état de la question. In: Revue française de pédagogie, volume 125, 1998. Ecole et culture religieuse. pp. 109-146

Patrons biogéographiques et structure génétique à grande échelle du complexes d’espèces ectomycorhizien Laccaria amethystina

International audienc

Patrons biogéographiques et structure génétique à grande échelle du complexes d’espèces ectomycorhizien Laccaria amethystina

International audienc

Removal of senescent cells reduces the viral load and attenuates pulmonary and systemic inflammation in SARS-CoV-2-infected, aged hamsters

International audienceOlder age is one of the strongest risk factors for severe COVID-19. In this study, we determined whether age-associated cellular senescence contributes to the severity of experimental COVID-19. Aged golden hamsters accumulate senescent cells in the lungs, and the senolytic drug ABT-263, a BCL-2 inhibitor, depletes these cells at baseline and during SARS-CoV-2 infection. Relative to young hamsters, aged hamsters had a greater viral load during the acute phase of infection and displayed higher levels of sequelae during the post-acute phase. Early treatment with ABT-263 lowered pulmonary viral load in aged (but not young) animals, an effect associated with lower expression of ACE2, the receptor for SARS-CoV-2. ABT-263 treatment also led to lower pulmonary and systemic levels of senescence-associated secretory phenotype factors and to amelioration of early and late lung disease. These data demonstrate the causative role of age-associated pre-existing senescent cells on COVID-19 severity and have clear clinical relevance