149 research outputs found
Precision Cosmological Constraints on Atomic Dark Matter
Atomic dark matter is a simple but highly theoretically motivated possibility
for an interacting dark sector that could constitute some or all of dark
matter. We perform a comprehensive study of precision cosmological observables
on minimal atomic dark matter, exploring for the first time the full parameter
space of dark QED coupling and dark electron and proton masses as well as the two cosmological parameters of aDM mass
fraction and temperature ratio at time of SM recombination. We
also show how aDM can accommodate the tension from late-time
measurements, leading to a better fit than CDM or CDM + dark
radiation. Furthermore, including late-time measurements leads to closed
contours of preferred and dark hydrogen binding energy. The dark proton
mass is seemingly unconstrained. Our results serve as an important new
jumping-off point for future precision studies of atomic dark matter at
non-linear and smaller scales.Comment: 29 pages + references, 2 tables, 13 figures v2: Significant
improvements and further performed checks for public CLASS-aDM code to
increase reliability across aDM parameter space. Reran all scans, used newer
KiDS-1000 measurement of S_8, no significant change to main results or
conclusions, but added plot showing preferred DeltaNeff and dark binding
energ
A Comparative Study of Effect of Propofol, Etomidate Lipuro and Propofol-Etomidate Lipuro Admixture on Haemodyanamic Response and on BIS Values at Induction of General Anaesthesia- A RCT
Background: Patients undergoing elective surgical procedures require an anesthetic agent which would provide a smooth, pleasant, rapid induction and recovery along with hemodynamic stability and minimal side effects. To achieve these goals Propofol, Etomidate and propofol – etomidate lipuro admixture may be the agents of choice. Bispectral index (BIS) monitoring has emerged as a convenient and versatile tool to titrate hypnotic agentsAim: 1. To compare the time of onset, of ,loss of consciousness and induction of anaesthesia using BIS index value among the propofol (1%), etomidate-lipuro (0.2%) and 50% (1:1) admixture of these agents (Etofol) in various procedures to choose the better induction agent. 2. To compare the hemodynamic changes caused by these agents.Material and methods:90 patients of either sex and of ASA physical status I or II scheduled for elective surgery under general anesthesia were selected for the study and were randomly placed into three groups. Group P was induced with intravenous Propofol 1%, Group E with intravenous Etomidate (2mg/ml) and Group PE with intravenous mixture of Propofol plus Etomidate (1:1) @ 400ml/hr till the BIS value reached 40. Patient was considered to be induced once the BIS value reached 40 and this time was noted for all three groups. BIS values and hemodynamic measurements were recorded before induction (T1), at induction (T2), before intubation (T3) after intubation (T4) and then after intubation, at 1 min (T5), at 3 min (T6), at 5 min (T7) and at 10 min (T8).Results: The Induction (time to reach BIS value of 40) was fastest in Etofol group. Induction dose of Etofol provided better control of BIS values after orotracheal intubation. It was also noted that Heart Rate remained near baseline in Etofol group at different time intervals. In the Post intubation period, a significant increase in the Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP) and Mean Arterial Pressure (MAP), was noted in Group E. The increase in blood pressure at different intervals after intubation was found to be lowest in Group PE.Conclusion: We conclude that Etofol is associated with a shorter induction time and better haemodyanamic stability than Etomidate and Propofol alone. It also provides effective control of BIS values during induction, orotracheal intubation and thereafter.
Key words: Etomidate, Propofol, Etofol, bispectral index (BIS) and haemodyanamic stability
Enhanced neutrino polarizability
We point out that neutrinos can have enhanced couplings to photons, if light
(pseudo)scalar mediators are present, resulting in potentially measurable
neutrino polarizability. We show that the expected suppression from small
neutrino masses can be compensated by the light mediator mass, generating
dimension 7 Rayleigh operators at low scales. We explore the rich phenomenology
of such models, computing in details the constraints on the viable parameter
space, spanned by the couplings of the mediator to neutrinos and photons.
Finally, we build several explicit models that lead to enhanced neutrino
polarizability by modifying the inverse see-saw majoron, i.e., the
pseudo-Nambu-Goldstone boson of the global lepton number responsible
for generating small neutrino masses.Comment: 48 pages, 9 figures. v2: Improved star cooling discussion. Corrected
bound from Xenon-nT. Added recast of monophoton searches discussion and EFT
bound. Submitted to JHE
Human Interpretation of Trade-Off Diagrams in Multi-Objective Problems: Implications for Developing Interactive Decision Support Systems
The growing need for efficient and effective human decision-makers warrants a better understanding of how decision support systems (DSS) guide users to improved decisions. Decision support approaches utilize visual aids to assist decision-making, including trade-off diagrams. These visualizations help comprehension of key trade-offs among decision alternatives. However, little is known about the role of trade-off diagrams in human decision-making and the best way to present them. Here, we discuss an empirical study with two goals: 1) evaluating DSS interactivity and 2) identifying decision-making strategies with trade-off diagrams. We specifically investigate the value of interface interactivity and problem context as users make nine increasingly complex decisions. Our results suggest that problem context and interactivity separately influence ability to navigate trade-off diagrams
Efficacy of short term versus long term antibiotic therapy in preventing deep wound infections in elective orthopaedic surgeries
Background: Comparison of the efficacy of short term (up to 48 hours) versus long term (five days) antibiotic therapy in preventing deep wound infections in elective orthopaedic surgeries.Methods: Two hundred patients of all ages and both sexes were divided into two groups of 100 patients. One group received long term antibiotic treatment consisting of 2 days intra-venous cefoperazone sulbactam 1.5 gm twice daily and intra-venous amikacin 500 mg twice daily followed by 3 days of oral amoxicillin clavulunate 625 mg thrice daily. Other group received short term antibiotic of 2 days intra-venous cefoperazone sulbactam 1.5 gm twice daily and intra-venous amikacin 500 mg twice daily. Comparison of SSI was done with age, sex, BMI, pre-operative haemoglobin, TLC, duration of surgery in both the groups.Results: In group I and group II respectively, average duration of surgery in procedures involving implants was 65.02±27.41 and 59.47±20.27 minutes and non implant related procedures was 53.66±23.97 and 53.74±22.40 minutes. Overall incidence of SSI in Group I and Group II was 14% and 10% respectively. Mean infection in the present study was 12%.Conclusions: It was concluded that in clean orthopaedic elective surgeries short term antibiotics regimen is as effective as long term antibiotics regimen. Continuing antibiotics for more than two days is associated with drug related complications like allergic reactions and gastrointestinal upset, adverse interactions in other drugs, development of resistant organisms and it adds to overall cost of treatment
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