Project Apollo - The effect of the selection of the cabin pressure on the environmental control system

Effect of cabin pressure on environmental control syste

A bibliography of six years (1951-1956) research in arithmetic

Thesis (Ed.M.)--Boston Universit

A Flower at Elmira: The Prisoner of War Diary of Wilbur Wightman Gramling

I-want-to-go-home-so-bad. These forlorn words, expressing such homesickness, appear lengthwise within the right margin on the last page of Wilbur Wightman Gramling\u27s pocket diary, a day-by-day journal of his experiences while imprisoned at Elmira Prisoner-of-War (POW) Camp in New York during the Civil War. Struck by a minie ball in the right arm and captured at the Battle of the Wilderness on May 6, 1864, Gramling, a private in Florida\u27s 5th Infantry, spent eleven months at Elmira Prison. The journal he faithfully kept throughout his imprisonment is the only known existing document of this type written by a Florida soldier.

Adhesion between atomically pure metallic surfaces, part IV Semiannual report

Adhesion between metal couples in vacuum environment and use of contact resistance measurements to evaluate surface contaminatio

A Semiempirical Investigation of Identity Reaction Proton Transfers

A semiempirical investigation of identity-reaction proton transfers using the AMI and PM3 methods has been carried out. Enthalpy differences between separated reactants and the ion-dipole complex (well depth) and between the complex and the transition structure (barrier height) were calculated. A comparison of carbon-to-carbon and oxygen-to-oxygen proton transfers led to the unexpected result that barriers were higher for the latter than for the former, in contrast to experimental observations in solution. The calculated values are compared with experiment and with ab initio calculations where possible, and the reliability of semiempirical calculations of well depths and barrier heights is assessed

Criminal Law - Resisting an Unlawful Arrest Punishable as a Misdemeanor under California Penal Code Section 834a. People v. Curtis (Cal. 1969)

This recent case discusses People v. Curtis (Cal. 1969)

Integrated control system for a gas turbine engine

A control system for a turbofan engine receives signals from a number of engine sensors and from the engine operator, and generates control signals. One control signal regulates the fan exhaust nozzle area in order to control inlet throat Mach number to maintain a low level of engine noise. Additional control signals regulate fuel flow to control engine thrust and fan pitch to control fan speed. A number of schedules are utilized to maintain a predetermined relationship between the controlled parameters and a number of fixed and calculated limits can override the control signals to prevent unsatisfactory engine performance

An Investigation of the Prevalence of Upper Limb Neuropathies in Different Types of College Musicians by Use of Neurometrix Device

In general, people who perform repetitive motions are often vulnerable to repetitive strain injuries. Because musicians must execute the same motion over and over again while practicing and performing their music, they are an example of a group that often develops these repetitive strain injuries. More specifically, musicians are known for developing neuropathies in their upper limbs, with carpal tunnel syndrome and cubital tunnel syndrome being most common. However, because of varying playing postures, all musicians may not be at equal risk for developing these two neuropathies, so the purpose of this study was to identify which musician group has the highest risk of developing median and ulnar neuropathies. Results of this study show that the prevalence of carpal tunnel syndrome and cubital tunnel syndrome is fairly low, and that tingling is one of the first signs of these diseases. Also, brass players may have the highest risk of developing carpal tunnel syndrome, as only this musician group had a significant p-value when its incidence rate of carpal tunnel syndrome was compared to the incidence rate found in the general population. Finally, the results suggest that there may be a negative correlation between performing a warm-up routine and experiencing tingling. Therefore, music schools should teach all students, and especially brass players, to be aware of tingling and to take appropriate preventative measure such as warming-up in order to keep the incidence rates of carpal tunnel syndrome and cubital tunnel syndrome as low as possible

A systematic review of the role of bisphosphonates in metastatic disease

Objectives: To identify evidence for the role of bisphosphonates in malignancy for the treatment of hypercalcaemia, prevention of skeletal morbidity and use in the adjuvant setting. To perform an economic review of current literature and model the cost effectiveness of bisphosphonates in the treatment of hypercalcaemia and prevention of skeletal morbidity Data sources: Electronic databases (1966-June 2001). Cochrane register. Pharmaceutical companies. Experts in the field. Handsearching of abstracts and leading oncology journals (1999-2001). Review methods: Two independent reviewers assessed studies for inclusion, according to predetermined criteria, and extracted relevant data. Overall event rates were pooled in a meta-analysis, odds ratios ( OR) were given with 95% confidence intervals (CI). Where data could not be combined, studies were reported individually and proportions compared using chi- squared analysis. Cost and cost-effectiveness were assessed by a decision analytic model comparing different bisphosphonate regimens for the treatment of hypercalcaemia; Markov models were employed to evaluate the use of bisphosphonates to prevent skeletal-related events (SRE) in patients with breast cancer and multiple myeloma. Results: For acute hypercalcaemia of malignancy, bisphosphonates normalised serum calcium in >70% of patients within 2-6 days. Pamidronate was more effective than control, etidronate, mithramycin and low-dose clodronate, but equal to high dose clodronate, in achieving normocalcaemia. Pamidronate prolongs ( doubles) the median time to relapse compared with clodronate or etidronate. For prevention of skeletal morbidity, bisphosphonates compared with placebo, significantly reduced the OR for fractures (OR [95% CI], vertebral, 0.69 [0.57-0.84], non-vertebral, 0.65 [0.54-0.79], combined, 0.65 [0.55-0.78]) radiotherapy 0.67 [0.57-0.79] and hypercalcaemia 0.54 [0.36-0.81] but not orthopaedic surgery 0.70 [0.46-1.05] or spinal cord compression 0.71 [0.47-1.08]. However, reduction in orthopaedic surgery was significant in studies that lasted over a year 0.59 [0.39-0.88]. Bisphosphonates significantly increased the time to first SRE but did not affect survival. Subanalyses were performed for disease groups, drugs and route of administration. Most evidence supports the use of intravenous aminobisphosphonates. For adjuvant use of bisphosphonates, Clodronate, given to patients with primary operable breast cancer and no metastatic disease, significantly reduced the number of patients developing bone metastases. This benefit was not maintained once regular administration had been discontinued. Two trials reported significant survival advantages in the treated groups. Bisphosphonates reduce the number of bone metastases in patients with both early and advanced breast cancer. Bisphosphonates are well tolerated with a low incidence of side-effects. Economic modelling showed that for acute hypercalcaemia, drugs with the longest cumulative duration of normocalcaemia were most cost-effective. Zoledronate 4 mg was the most costly, but most cost-effective treatment. For skeletal morbidity, Markov models estimated that the overall cost of bisphosphonate therapy to prevent an SRE was pound250 and pound1500 per event for patients with breast cancer and multiple myeloma, respectively. Bisphosphonate treatment is sometimes cost-saving in breast cancer patients where fractures are prevented. Conclusions: High dose aminobisphosphonates are most effective for the treatment of acute hypercalcaemia and delay time to relapse. Bisphosphonates significantly reduce SREs and delay the time to first SRE in patients with bony metastatic disease but do not affect survival. Benefit is demonstrated after administration for at least 6-12 months. The greatest body of evidence supports the use of intravenous aminobisphosphonates. Further evidence is required to support use in the adjuvant setting