Tyrosinase and phenolic pressor amines

Basic to the consideration of the action of tyrosinase on the oxidation of phenolic pressor amines are the observations of Keilin and Mann (16) and of Nelson and his coworkers (17-19) that show that different preparations may vary considerably in their relative actions on monophenols and o-diphenols. Both of these types of activity appear to belong to the same enzyme complex, as they bear a proportionality to the same copper content. However, since the activities vary with the purity and method of purification, each enzyme preparation must be defined in terms of both monophenolase and o-diphenolase activities. This was done in the present studies, and modifications of previously described preparative methods were required to retain a reasonable proportioning of such activities in purified preparations

Detecting early signs of depressive and manic episodes in patients with bipolar disorder using the signature-based model

Recurrent major mood episodes and subsyndromal mood instability cause substantial disability in patients with bipolar disorder. Early identification of mood episodes enabling timely mood stabilisation is an important clinical goal. Recent technological advances allow the prospective reporting of mood in real time enabling more accurate, efficient data capture. The complex nature of these data streams in combination with challenge of deriving meaning from missing data mean pose a significant analytic challenge. The signature method is derived from stochastic analysis and has the ability to capture important properties of complex ordered time series data. To explore whether the onset of episodes of mania and depression can be identified using self-reported mood data.Comment: 12 pages, 3 tables, 10 figure

Valuing conservation benefits of disease control in wildlife: A choice experiment approach to bovine tuberculosis management in New Zealand's native forests

We assess the non-monetary environmental benefits that accrue incidentally in New Zealand (NZ) from pest management conducted primarily to control an animal disease, bovine tuberculosis (TB). TB is an infectious disease that is one of the world's most serious animal health problems and, in many parts of the developing world, still a major mortality risk for humans. The incidence of TB in New Zealand (NZ) farmed livestock has been reduced progressively over the last 20 years, largely due to extensive and sustained population control of the main wildlife reservoir of disease, the introduced brushtail possum. Possums are also major pests that threaten indigenous forest biodiversity, and so extensive possum control for TB mitigation also incidental benefits conservation, but the extent and public value of this benefit has yet to be quantified. We conducted a choice experiment survey of the NZ public in an effort to value the native forest biodiversity benefits of TB-related possum control. We find strong public support for conservation outcomes consequent to TB-possum control in public native forests. The public place substantial value on the most observable biodiversity benefits of TB possum control, such as improved forest canopies and presence of native birds. The benefits, costs and values of TB-possum control are discussed in relation to the future directives of NZ's TB control programme, which is headed toward first regional and then national level disease eradication

New Zealand food and beverage consumer preferences for product attributes and alternative retailers, and in-market use of digital media and smart technology

While much of New Zealand’s primary products are exported, it is still important to understand how domestic consumers value the attributes of food and beverage products, including willingness-to-pay (WTP) for particular product attributes, and use digital media and smart technologies to access information and purchasing food and beverage products. In response to this, firstly a literature review of New Zealand consumer preferences, WTP and technology use was carried out. Secondly, a survey of approximately 1,400 New Zealand consumers was undertaken examining preferences and WTP for credence attributes and their associated factors, attitudes to and use of alternative retailers, and digital media and smart technology use in relation to food and beverages. These results are compared with an overseas study to gain relative insight into the New Zealand market. A distinct difference between New Zealand and international consumers is observed across all factors examined. These results imply that a New Zealand-centric view of international consumers may lead to an underestimation of the potential value that could be captured in international markets

Short-range order and precipitation in Fe-rich Fe-Cr alloys: Atomistic off-lattice Monte Carlo simulations

Short-range order (SRO) in Fe-rich Fe-Cr alloys is investigated by means of atomistic off-lattice Monte Carlo simulations in the semi-grand canonical ensemble using classical interatomic potentials. The SRO parameter defined by Cowley [Phys. Rev. B 77, 669 (1950)] is used to quantify the degree of ordering. In agreement with experiments a strong ordering tendency in the Cr distribution at low Cr concentrations (~< 5%) is observed, as manifested in negative values of the SRO parameters. For intermediate Cr concentrations (5% ~< c_Cr ~< 15%) the SRO parameter for the alpha-phase goes through a minimum, but at the solubility limit the alpha-phase still displays a rather strong SRO. In thermodynamic equilibrium for concentrations within the two-phase region the SRO parameter measured over the entire sample therefore comprises the contributions from both the alpha and alpha-prime phases. If both of these contributions are taken into account, it is possible to quantitatively reproduce the experimental results and interpret their physical implications. It is thereby shown that the inversion of the SRO observed experimentally is due to the formation of stable (supercritical) alpha-prime precipitates. It is not related to the loss of SRO in the alpha-phase or to the presence of unstable (subcritical) Cr precipitates in the alpha-phase.Comment: 9 pages, 8 figure

Characterization of the Impaired Glucose Homeostasis Produced in C57BL/6 Mice by Chronic Exposure to Arsenic and High-Fat Diet

Background: Type 2 diabetes is characterized by glucose intolerance and insulin resistance. Obesity is the leading cause of type 2 diabetes. Growing evidence suggests that chronic exposure to inorganic arsenic (iAs) also produces symptoms consistent with diabetes. Thus, iAs exposure may further increase the risk of diabetes in obese individuals

California apple consumer consumption behaviours and product preferences: A Latent Class Analysis

This study is part of a research programme entitled Unlocking Export Prosperity from the Agri-food Values of Aotearoa New Zealand. It is funded by the Ministry of Business, Innovation and Employment (MBIE) Endeavour Fund for science research programmes. The research aims to provide new knowledge on how local enterprises can achieve higher returns by ensuring global consumers understand the distinctive qualities of the physical, credence and cultural attributes of agri-food products that are “Made in New Zealand”. Agricultural exports are an important contributor to the New Zealand (NZ) economy. It is critically important for NZ exporters to understand export markets and the different cultures and preferences of those consumers to safeguard market access, and for realising potential premiums. This report describes the application of a survey of Californian apple consumers that is designed to examine consumption behaviour and consumer Willingness-to Pay (WTP) for credence attributes. While search attributes such as price or colour can be observed directly, and experience attributes such as flavour can be assessed when consumed, credence attributes such as environmental sustainability cannot be immediately seen or experienced at the point of sale. For products promoting credence attributes, the role of verification including labelling is of significant importance. Our approach is to apply a Choice Experiment economic valuation method, analysed using a statistical approach called Latent Class Modelling that describes profiles for different consumer segments identified in the data and provides estimates of attribute WTP across these segments

Characterization of the Impaired Glucose Homeostasis Produced in C57BL/6 Mice by Chronic Exposure to Arsenic and High-Fat Diet

Background: Type 2 diabetes is characterized by glucose intolerance and insulin resistance. Obesity is the leading cause of type 2 diabetes. Growing evidence suggests that chronic exposure to inorganic arsenic (iAs) also produces symptoms consistent with diabetes. Thus, iAs exposure may further increase the risk of diabetes in obese individuals

Crystal engineering urea organic acid hydrogen bonded networks with solvent inclusion properties

Eleven structurally similar materials based on hydrogen bonded networks of N-phenylurea and 5-nitroisophthalic acid have been engineered where nine have interesting solvent inclusion and guest release properties.</p

Texas Sauvignon blanc wine consumer consumption behaviours and product preferences: A Latent Class Analysis

The Agribusiness and Economics Research Unit (AERU) at Lincoln University with the support of research partners under the Unlocking Export Prosperity from the Agri-food Values of Aotearoa New Zealand research programme has estimated willingness-to-pay (WTP) values for selected credence attributes of Sauvignon blanc wine by Texan consumers, with a focus on identifying preferences for attributes considered distinctively New Zealand