Medical Residents of Family Medicine Management of Depression, Anxiety and Burnout Syndrome in KSA

This study aimed at analyzing the Medical Residents of family medicine management of depression, anxiety and burnout syndrome in Kingdom Saudi Arabia. This study also describes the relationship between wellness behaviors and measures of well-being at the start of family medicine residency in Kingdom Saudi Arabia. The researcher adopted the Methodology of descriptive statistics. And the study concluded that the innovative curriculum and activities that focus on wellness behaviors and healthy lifestyle choices for physicians in training are needed. The ACGME mandate on implementation of duty hours for residents may show a positive effect in future generations of physicians. Family medicine programs can lead in creating additional institutional methodologies to support a culture of wellness for residents, faculty, and staff, thus promoting a lifelong commitment to self-care and an emphasis on prevention and health promotion for our patients.

Effect of atmosphere on the tear film layer

Aim: to demonstrate the effect of the atmosphere (heat and humidity) on the eye by comparing the outdoor and indoor workers.  Method: 120 eyes of 60 subjects volunteers from the Saudi electrical company (SECO), their age range was 24 to 40 years. The Schirmer strips test and break up time test were used to evaluates tear film quantity and quality. Result: The results demonstrate that there is a statistical significant difference in tear film quantity and quality between the outdoor and indoor subjects using the Schirmer test and break up time test. Conclusion: This study show the effect of atmosphere heat and humidity on the tear film layer, and the results demonstrate that there significant difference in the tear film quantity and quality between the outdoor and the indoor subjects

Effect of Atmosphere on the Tear Film Layer

Aim: to demonstrate the effect of the atmosphere (heat and humidity) on the eye by comparing the outdoor and indoor workers.  Method: 120 eyes of 60 subjects volunteers from the Saudi electrical company (SECO), their age range was 24 to 40 years. The Schirmer strips test and break up time test were used to evaluates tear film quantity and quality. Result: The results demonstrate that there is a statistical significant difference in tear film quantity and quality between the outdoor and indoor subjects using the Schirmer test and break up time test. Conclusion: This study show the effect of atmosphere heat and humidity on the tear film layer, and the results demonstrate that there significant difference in the tear film quantity and quality between the outdoor and the indoor subjects

Seasonal variations of respiratory viruses detected from children with respiratory tract infections in Riyadh, Saudi Arabia

ARTIs have a huge impact in health systems in which 20–30% of all hospital admissions and 30–60% of practitioner visits are related to respiratory tract infections. The aim of this study is to determine the prevalence, age distribution, and seasonal variation of respiratory viruses. This study was descriptive retrospective study in which all patients 14 years of age and below who presented with signs and symptoms of ARTIs between January 2013 and December 2014 and had respiratory specimen tested by direct immunofluorescence assays for viruses identification were included in the study. During that period, a total of 4611 patients who presented with ARTIs from January 2013 to December 2014 were investigated, viruses were detected in 1115 (24%). RSV was associated with 97.4% of the total viral pathogens. Viruses were detected throughout all the two years with a peak in winter; Dec (n: 265), Jan (n: 418), Feb (n: 218), and Mar (n: 109). Viral pathogens are very important cause of ARTIs in our region. RSV was the most common virus detected with the highest detection rate in children who are two years old and below. A multi-center surveillance with more sensitive detection methods like PCR may help to provide a comprehensive understanding of virus distribution in our area, which may contribute implant an effective prevention approach for each virus. Keywords: Pediatrics, Infectious diseases, Respiratory infections, Respiratory syncytial virus, Saudi Arabi

Differential Expression of LMNA/C and Insulin Receptor Transcript Variants in Peripheral Blood Mononuclear Cells of Leukemia Patients

Background: Recent research has identified alternative transcript variants of LMNA/C (LMNA, LMNC, LMNAΔ10, and LMNAΔ50) and insulin receptors (INSRs) as potential biomarkers for various types of cancer. The objective of this study was to assess the expression of LMNA/C and INSR transcript variants in peripheral blood mononuclear cells (PBMCs) of leukemia patients to investigate their potential as diagnostic biomarkers. Methods: Quantitative TaqMan reverse transcriptase polymerase chain reaction (RT-qPCR) was utilized to quantify the mRNA levels of LMNA/C (LMNA, LMNC, LMNAΔ10, and LMNAΔ50) as well as INSR (IR-A and IR-B) variants in PBMCs obtained from healthy individuals (n = 32) and patients diagnosed with primary leukemias (acute myeloid leukemia (AML): n = 17; acute lymphoblastic leukemia (ALL): n = 8; chronic myeloid leukemia (CML): n = 5; and chronic lymphocytic leukemia (CLL): n = 15). Results: Only LMNA and LMNC transcripts were notably present in PBMCs. Both exhibited significantly decreased expression levels in leukemia patients compared to the healthy control group. Particularly, the LMNC:LMNA ratio was notably higher in AML patients. Interestingly, IR-B expression was not detectable in any of the PBMC samples, precluding the calculation of the IR-A:IR-B ratio as a diagnostic marker. Despite reduced expression across all types of leukemia, IR-A levels remained detectable, indicating its potential involvement in disease progression. Conclusions: This study highlights the distinct expression patterns of LMNA/C and INSR transcript variants in PBMCs of leukemia patients. The LMNC:LMNA ratio shows promise as a potential diagnostic indicator for AML, while further research is necessary to understand the role of IR-A in leukemia pathogenesis and its potential as a therapeutic target