ANALYSIS OF PATIENT ADMISSIONS IN HOSPITAL DUE TO ADVERSE DRUG REACTION

The present study is prospective and observational non-interventional study was conducted in tertiary care center. All suspected ADRs which are observed in hospital stay will be assessed for causality, severity, preventability and predictability. The results were presented as number and percentage. Among the 7697 cases ( both males and females), a total of 240 ADRs were detected, an overall incidence of 03.11 % adverse drug reactions in inpatients. The high prevalence of ADR mostly observed in the age group between 1-10 years 48 (20.00%)  From this 240 ADR’s where 7.96% on continuing t, 38.36% are recovering, 47.08% are recovered. Keywords: Adverse drug reaction, Causality, Severity, Preventability, Probability

A PROSPECTIVE STUDY OF CLINICAL PROFILE OF STROKE IN A TERTIARY CARE HOSPITAL

ABSTRACTObjective: The objective of the work was to study the clinical profile of stroke in a tertiary care hospital.Methods: A prospective observational study on stroke was carried out for a period of 6-month (May 2015 to October 2015). A total of 241 inpatientsfrom Shri Preethi Hospital were incorporated in the study. The data were collected and evaluated by reviewing case files and patient interview.Result and Conclusion: Out of 241 patients, an incidence of ischemic stroke was found to be higher. The occurrence of stroke steeply rises with agewith male predominance. The burden of stroke tends to be more in rural, illiterate, and low socioeconomic status population. The study reveals riskfactors such as sedentary lifestyle, previous and family history of stroke, underlying disease like hypertension, diabetes. The circadian pattern in onsetshowed a significant peak in morning (6 am-12 pm) for Ischemic and afternoon (12 pm-6 pm) for hemorrhagic stroke. Topographic distribution ofcerebral infract and hemorrhage was found to be in parietal lobe and periventricular white matter, respectively. Mostly prescribed medication forischemic and hemorrhagic patients was antihypertensive and mannitol, respectively. The contraindication for thrombolytic therapy was found to below economic status and average delay in time of presentation to hospital. The study highlights the need for aggressive management of traditionalrisk factors, need for extensive work up in patient to find etiologies and need for more active interventions in community for the prevention of stroke.Keywords: Ischemic, Hemorrhagic, Circadian pattern, Antihypertensive

Different Types of Connected Spaces

This paper deals with the various forms of open sets and their relations. The relation is represented by a diagram. The relation is same for the closed sets also. The main part defines different types of connectedness and their relations. It is notable that openness and connectedness are in opposite order. Some results on Q-sets are also included here

Subordination Properties for Certain Subclasses of Prestarlike Functions

Making use of generalized Saˇlaˇgean derivative operator in this paper, we define a unified class of starlike functions with negative coefficients and obtain subordination results, partial sums, integral transforms for this class. Further integral means and square root transformation results are discussed

Reduction of liver fibrosis by rationally designed macromolecular telmisartan prodrugs

At present there are no drugs for the treatment of chronic liver fibrosis that have been approved by the Food and Drug Administration of the United States. Telmisartan, a small-molecule antihypertensive drug, displays antifibrotic activity, but its clinical use is limited because it causes systemic hypotension. Here, we report the scalable and convergent synthesis of macromolecular telmisartan prodrugs optimized for preferential release in diseased liver tissue. We have optimized the release of active telmisartan in fibrotic liver to be depot-like (that is, a constant therapeutic concentration) through the molecular design of telmisartan brush-arm star polymers, and show that these lead to improved efficacy and to the avoidance of dose-limiting hypotension in both metabolically and chemically induced mouse models of hepatic fibrosis, as determined by histopathology, enzyme levels in the liver, intact-tissue protein markers, hepatocyte necrosis protection and gene-expression analyses. In rats and dogs, the prodrugs are retained long term in liver tissue, and have a well-tolerated safety profile. Our findings support the further development of telmisartan prodrugs that enable infrequent dosing in the treatment of liver fibrosis.National Institutes of Health (U.S.) (Grant 1R01CA220468-01)National Institutes of Health (U.S.) (Fellowship 1F32EB023101