139 research outputs found
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The purpose of this paper was investigate the effect of parents\u27 Playcentre participation in Japan, and to compare the impact of different Japan and New Zealand Playcentre participants. The focus was on social networks, and theformation of trust and norm of reciprocity generating social capitals which operates to empower parents themselves, their families and communities. Japanese parents with preschool aged children in the Picasso Playcentre (Tokyo area) and Eniwa Playcentre (Hokkaido, the northern island of Japan) were interviewed. The findings are interpreted as follows: Japanese parents being involved in adult education and Playcentre activities was significantly associated with positive outcomes with regards to child-rearing attitudes and diverse other contemporary Japanese social problems. These were compared with Satoh\u27s own research in New Zealand and findings from the NZPF commissioned research Powell et al. (2005), The Effect of Adult Playcentre Participation on the Creation of Social capital in Local Communities.1
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The Golgin Tether Giantin Regulates the Secretory Pathway by Controlling Stack Organization within Golgi Apparatus
Golgins are coiled-coil proteins that play a key role in the regulation of Golgi architecture and function. Giantin, the largest golgin in mammals, forms a complex with p115, rab1, GM130, and soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs), thereby facilitating vesicle tethering and fusion processes around the Golgi apparatus. Treatment with the microtubule destabilizing drug nocodazole transforms the Golgi ribbon into individual Golgi stacks. Here we show that siRNA-mediated depletion of giantin resulted in more dispersed Golgi stacks after nocodazole treatment than by control treatment, without changing the average cisternal length. Furthermore, depletion of giantin caused an increase in cargo transport that was associated with altered cell surface protein glycosylation. Drosophila S2 cells are known to have dispersed Golgi stacks and no giantin homolog. The exogenous expression of mammalian giantin cDNA in S2 cells resulted in clustered Golgi stacks, similar to the Golgi ribbon in mammalian cells. These results suggest that the spatial organization of the Golgi ribbon is mediated by giantin, which also plays a role in cargo transport and sugar modifications
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