Glucose-6-phosphate dehydrogenase deficiency

WOS: 000266933800007Glucose-6-phosphate dehydrogenase (G6PD) is the first enzyme of the pentose phosphate pathway, providing reducing power to all cells in the form of reduced form of nicotinamide adenine dinucleotide phosphate. G6PD deficiency is the most common human enzyme defect, being present in more than 400 million people worldwide. G6PD deficiency is an X-linked, hereditary genetic defect caused by mutations in the G6PD gene. Clinical presentations include acute hemolytic anemia, chronic hemolytic anemia, neonatal jaundice, and favism, which is usually triggered by an exogenous agent. (Turk Arch Ped 2009; 44 Suppl: 35-8

The experience of BK polyoma virus infection treatment after allogeneic hematopoietic stem cell transplantation in pediatric patients

44th Annual Meeting of the European-Society-for-Blood-and-Marrow-Transplantation (EBMT) -- MAR 18-21, 2018 -- Lisbon, PORTUGALWOS: 000487702807050…European Soc Blood & Marrow Transplanta

The experience using of eltrombopag for treatment of thrombocytopenia after allogeneic hematopoetic stem cell transplantation in pediatric patients

44th Annual Meeting of the European-Society-for-Blood-and-Marrow-Transplantation (EBMT) -- MAR 18-21, 2018 -- Lisbon, PORTUGALWOS: 000487702807052…European Soc Blood & Marrow Transplanta

Treatment and risk factors of hepatic veno-occlusive disease after pediatric hematopoietic stem cell transplantation: A single-center experience

45th Annual Meeting of the European-Society-for-Blood-and-Marrow-Transplantation (EBMT) -- MAR 24-27, 2019 -- Frankfurt, GERMANYWOS: 000487707800323…European Soc Blood & Marrow Transplanta

Stroke in sickle cell anemia: A case report

22nd International Congress on Thrombosis -- OCT 06-09, 2012 -- Nice, FRANCEWOS: 000310349200189

The Prognostic Significance of Serum Tumor Necrosis Factor (TNF)-Related Apoptosis-Inducing Ligand (TRAIL) in Childhood Acute Leukemias

WOS: 000363969000016Purpose: Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a TNF superfamily member. TRAIL is transmembrane protein expressed on cell surfaces and has a broad expression pattern in a variety of organs. Cleavage of its C-terminal part (extracellular domain) allows for a soluble form of TRAIL. TRAIL induces apoptosis with its receptors TRAIL-receptor 1 (TRAIL-R1), TRAIL-receptor 2 (TRAIL-R2) however apoptosis can not be induced by receptors TRAIL-receptor 3 (TRAIL-R3) and TRAIL-receptor 4 (TRAIL-R4). There are many trials to search the correlation between leukemia and apoptotic pathway disorders. In this study we determined the seum levels of TRAIL in acute childhood leukemias at first diagnose. We aimed to determine the relation between the levels of serum TRAIL and patient's survey, clinical parameters. Material and Methods: The study was performed in patients admitted to Pediatric Hematology and Pediatric Oncology Department of Cukurova University Medical Faculty between October 2009 and July 2010. Twenty-three cases with new diagnosis acute lymphoblastic leukemia (ALL) at the age disturbition 9-months-12-year and 8-months and fourteen cases with new diagnosis acute myeloblastic leukemia (AML) at the age disturbition of 9 days-18 years are included in this study. Twenty-one healty children with no blood disease with similar sex and age with leukemia group was chosen as the control group. Serum TRAIL levels were determined by using ELISA method. Results: The comparison of the average values of the TRAIL levels in acute leukemia patients and control group have shown that patients with leukemia have low serum TRAIL levels (p = 0.002). In patients with high-risk-grade (HRG) of ALL compared with control group have shown low serum TRAIL levels in HRG of ALL (p = 0.008). In patients with common acute lymphoblastic leukemia antigen(CALLA)(-) B ALL compared with control group have shown low serum TRAIL levels in CALLA(-) B ALL (p = 0.004). Children with acute leukemias (ALL, AML) who died during treatment compared with survived group have shown low levels of serum TRAIL in expired patients (p = 0.004). Conclusion: As a result, serum TRAIL might play a role in leukomegenesis. The low levels of serum TRAIL detected in our patients may be associated with leukomogenezis and impaired TRAIL-mediated apoptosis. To suggest soluble TRAIL's role in acute leukemias detection of TRAIL-mediated apoptosis is needed. The low serum TRAIL may be used as a sign of bad prognosis. For more comphrensive results prospective studies with greaater number of patients are needed

Stroke in a Pediatric Immune Thrombocytopenia Case

60th Annual Meeting of the American-Society-of-Hematology (ASH) -- DEC 01-04, 2018 -- San Diego, CAWOS: 000454842805280…Amer Soc Hemato