New Supporting Evidence for the Overdensity of Galaxies around the Radio-Loud Quasar SDSS J0836+0054 at z =5.8

Recently, Zheng et al. (2005) found evidence for an overdensity of galaxies around a radio-loud quasar, SDSS J0836+0054, at z=5.8 (a five arcmin$^2$ region). We have examined our deep optical imaging data (B, V, r', i', z', and NB816) taken with the Suprime-Cam on the Subaru Telescope. The NB816 narrow-band filter (lambda_c = 815 nm and $\Delta\lambda = 12$ nm) is suitable for searching for Ly$\alpha$ emitters at $z\approx 5.7$. We have found a new strong Ly$\alpha$ emitter at $z \approx 5.7$ close to object B identified by Zheng et al. Further, the non detection of the nine objects selected by Zheng et al. (2005) in our B, V, and r' images provides supporting evidence that they are high-z objects.Comment: 5 pages, 1 figure, accepted for PAS

Strong Emission-Line Galaxies at Low Redshift in the Field around the Quasar SDSSp J104433.04-012502.2

We discuss observational properties of strong emission-line galaxies at low redshift found by our deep imaging survey for high-redshift Ly alpha emitters. In our surveys, we used the narrowband filter, NB816 (lambda_center=8150A with FWHM = 120A), and the intermediate-band filter, IA827 (lambda_center = 8270A with FWHM = 340A). In this survey, 62 NB816-excess (> 0.9 mag) and 21 IA827-excess (> 0.8 mag) objects were found. Among them, we found 20 NB816-excess and 4 IA827-excess Ly alpha emitter candidates. Therefore, it turns out that 42 NB816-excess and 17 IA827-excess objects are strong emission-line objects at lower redshift. Since 4 objects in the two low-z samples are common, the total number of strong low-z emitters is 55. Applying our photometric redshift technique, we identify 7 H alpha emitters at z~0.24, 20 H beta-[OIII] ones at z~0.65, and 11 [OII] ones at z~1.19. However, we cannot determine reliable photometric redshifts of the remaining 17 emitters. The distributions of their rest frame equivalent widths are consistently understood with recent studies of galaxy evolution from z~1 to z~0.Comment: 28 pages, 8 figures, PASJ, Vol. 58, No. 1, in pres

Factors associated with the severity of childhood rhinoconjunctivitis

AbstractBackgroundAllergic rhinitis is one of the most common chronic diseases in children. Although it has a large impact on the patient's quality of life, little is known about the factors associated with its severity. The aim of this study was to assess the factors associated with the severity of rhinoconjunctivitis among children in the general population.MethodsA survey was conducted using an online research panel in 2012. Parents were asked to answer an International Study of Asthma and Allergies in Childhood-based questionnaire to identify children with current rhinoconjunctivitis and evaluate factors associated with the severity of its symptoms. Severity was rated according to the degree of impairment caused by the symptoms in the patient's daily life.ResultsAmong 26,725 children aged 6–12 years old, rhinoconjunctivitis was defined in 5175 (19.4%), and of these, 688 children (13.3% of children with current rhinoconjunctivitis) presented severe symptoms. Living in areas with a high cedar and cypress pollen count and having concurrent eczema were associated with severe rhinoconjunctivitis [adjusted OR (95% CI): 1.21 (1.00–1.46) and 1.45 (1.20–1.75), respectively]. Further, a maternal history of asthma and allergic rhinitis was a significant risk factor for severe rhinoconjunctivitis [1.34 (1.04–1.74) and 1.30 (1.10–1.53), respectively]. However, living with fur-bearing animals (pets) before 1 year of age proved to be a protective factor against severe rhinoconjunctivitis [0.70 (0.52–0.94)].ConclusionsEnvironmental factors such as pets and pollen, together with comorbidities and a maternal history of allergic diseases, play an important role in determining the severity of rhinoconjunctivitis

Dendritic retraction, but not atrophy, is consistent in amyotrophic lateral sclerosis-comparison between Onuf’s neurons and other sacral motor neurons-

BACKGROUND: Fundamental cytological changes of amyotrophic lateral sclerosis (ALS) were looked for by comparing relatively preserved Onuf’s nucleus (ON) and severely affected neighboring motor neuron groups (dorsolateral alpha motoneurons (DL) and other anterior horn neurons (OAH)). The second sacral segments from 11 ALS patients and 5 controls were initially quadruple-labeled for phosphorylated and non-phosphorylated TAR DNA-binding protein of 43 kDa (TDP43), and p62 with DAPI to identify TDP43-related changes. After digital recording of these fluorescence data encompassing the entire specimen at a high resolution, the same sections were stained with Klüver-Barrera method to obtain their exact bright-field counterparts. This novel approach facilitated exact identification of ON. Furthermore, this cell to cell comparison enabled to correlate quantitative indices of the neuronal cell bodies: perimeter, area and circularity index (CI) i.e. the ratio of (perimeter/2π) divided by the square root of (area/π), which decreases with dendritic retraction, overall number of neurons and inclusions. RESULTS: In addition to known preservation of ON neuron number relative to DL and OAH, size reduction of ON neurons was not significant even in the advanced stage. Significant size reduction in DL was counteracted in the presence of TDP43-positive inclusions. Early increase of neuronal size in OAH was further enhanced by the presence of TDP43-positive inclusions. Even with these heterogeneous cytopathological changes, a decrease in CI was consistent in all groups at an early phase and was correlated with neuronal loss. CONCLUSIONS: Among variable cytological changes of ALS, a decrease in CI is a consistent early feature shared between non-atrophic ON neurons and other anterior horn neurons with either decreased (DL) or even increased (OAH) size and profounder neuronal loss. This decrease in CI, representative of dendritic retraction, is fundamental to ALS pathogenesis, not necessarily linked to cell size and pathological inclusions

Significance of High-frequency Electrical Brain Activity

　Electroencephalogram (EEG) data include broadband electrical brain activity ranging from infra-slow bands (200 / 250 Hz, respectively) are particularly of note due to their very close relationship to epileptogenicity, with the possibility that they could function as a surrogate biomarker of epileptogenicity. In contrast, physiological high-frequency activity plays an important role in higher brain functions, and the differentiation between pathological / epileptic and physiological HFOs is a critical issue, especially in epilepsy surgery. HFOs were initially recorded with intracranial electrodes in patients with intractable epilepsy as part of a long-term invasive seizure monitoring study. However, fast oscillations (FOs) in the ripple and gamma bands (40-80 Hz) are now noninvasively detected by scalp EEG and magnetoencephalography, and thus the scope of studies on HFOs /FOs is rapidly expanding