Association of Cytokine Gene Polymorphisms (IL6, IL10, TNF-alpha, TGF-beta and IFN-gamma) and Graves' Disease in Turkish Population

Introduction: Cytokines play a crucial role in the pathogenesis of autoimmune thyroid disease, and recent studies have demonstrated an association between cytokine gene polymorphisms and Graves' Disease (GD) in different ethnic groups. The aim of the present study was to investigate the relationship of interleukin-6 (IL-6), IL-10, tumor necrosis factor-alpha (TNF-alpha), transforming growth factor-beta (TGF-beta), and interferon-gamma (INF-gamma) gene polymorphisms in the development of GD in Turkish population

Low frequency of HLA-B27 in ankylosing spondylitis patients from Turkey

Objectives: Ankylosing spondylitis is strongly associated with HLA-B27. However, the strength of the association with HLA-B27 and the clinical features may vary in different parts of the world. The aim of this study is to compare the clinical features of AS and the frequencies of HLA-B27 and its alleles in patients from Turkey with other series