EVALUATION OF SERUM NITRIC OXIDE IN ESSENTIAL HYPERTENSION AND ITS CORRELATION WITH SEVERITY OF DISEASE

ABSTRACTObjective: Hypertension is the most common cardiovascular disease and one of the most important public health concerns all over the world. Primaryor essential hypertension is the major form of arterial hypertension without any definitive cause. It results from increase vascular tone and resistancewhich may be confined to the lower level of endothelial derived relaxing factor such as nitric oxide (NO). Hence, the objective of this study is to findout whether any correlation exists between the concentrations of serum NO (nitrite) and essential hypertensive patients categorized according to theJoint National Committee 7 classification.Methods: We selected age- and sex-matched 24 healthy individuals as controls and 35 essential hypertensive patients as cases. Out of 35 cases, 24were included in stage 1 and 11 in stage 2 of essential hypertension. We estimated serum NO levels in study groups basing on the principle of Griessreaction.Results: We observed reduction in mean serum NO level in cases which was statistically highly significant as compared to controls (8.14±0.33 vs.13.53±0.38 µmol/L, p<0.001) and also in stage 2 patients when compared with stage 1 patients (5.97±0.31 vs. 9.15±0.28 µmol/L, p<0.001). Inhypertensive patients, serum NO showed a highly significant inverse correlation to both systolic (r=−0.89, p<0.001) as well as diastolic (r=−0.64,p<0.001) blood pressure.Conclusion: Thus, we can conclude that lower level of serum NO can be an important causative factor in the progress of essential hypertension.Keywords: Essential hypertension, Endothelial-derived relaxing factor, Nitric oxide, Joint National Committee 7

Performance of summer sunflower (Helianthus annuus L.) hybrids under different nutrient management practices in coastal Odisha

The field experiment was conducted at Department of Agronomy, College of Agriculture, OUAT, Bhubaneswar during summer 2014 to find out appropriate hybrids and nutrient management practices for summer sunflower. Application of recommended dose of Fertiliser(RDF) i.e. 60-80- 60 kg N, P2O5-K2O ha -1 + ZnSO4 @ 25 kg ha -1 recorded the maximum capitulum diameter (15.60cm), seed yield (2.17 t ha -1 ), stover yield (4.88 t ha -1 ) and oil yield (0.91 t ha -1 ), while application of RDF + Boron@ 1 kg ha-1 recorded the highest number of total seed (970) and filled seed per capitulum (890) with the lowest unfilled seed (80) and sterility percentage (9.0%). The hybrid ‘Super-48’ recorded the highest seed and oil yield of 2.17 and 0.91 t ha -1 , respectively, at recommended dose of fertiliser + ZnSO4 @ 25 kg ha -1 . Experiment was conducted in evaluating the new hybrids in addition to evaluate the response of variety to different nutrient management practices

Dynamics of Hot QCD Matter -- Current Status and Developments

The discovery and characterization of hot and dense QCD matter, known as Quark Gluon Plasma (QGP), remains the most international collaborative effort and synergy between theorists and experimentalists in modern nuclear physics to date. The experimentalists around the world not only collect an unprecedented amount of data in heavy-ion collisions, at Relativistic Heavy Ion Collider (RHIC), at Brookhaven National Laboratory (BNL) in New York, USA, and the Large Hadron Collider (LHC), at CERN in Geneva, Switzerland but also analyze these data to unravel the mystery of this new phase of matter that filled a few microseconds old universe, just after the Big Bang. In the meantime, advancements in theoretical works and computing capability extend our wisdom about the hot-dense QCD matter and its dynamics through mathematical equations. The exchange of ideas between experimentalists and theoreticians is crucial for the progress of our knowledge. The motivation of this first conference named "HOT QCD Matter 2022" is to bring the community together to have a discourse on this topic. In this article, there are 36 sections discussing various topics in the field of relativistic heavy-ion collisions and related phenomena that cover a snapshot of the current experimental observations and theoretical progress. This article begins with the theoretical overview of relativistic spin-hydrodynamics in the presence of the external magnetic field, followed by the Lattice QCD results on heavy quarks in QGP, and finally, it ends with an overview of experiment results.Comment: Compilation of the contributions (148 pages) as presented in the `Hot QCD Matter 2022 conference', held from May 12 to 14, 2022, jointly organized by IIT Goa & Goa University, Goa, Indi

Childhood Vasculitis Syndrome Mimicking Guillain Barre Syndrome

Background: Childhood vasculitis is a heterogeneous disorder, characterized by inflammation of the blood vessel walls. Multiple organs and/or tissues are affected, either simultaneously or successively. Vascular neuropathy occurs when the vasa nervorum is affected. Presentation includes mononeuritis multiplex, acute motor/motor-sensory axonal neuropathy, pure sensory neuropathy, and chronic inflammatory demyelinating polyneuropathy. Making a diagnosis is a challenge when neurological manifestations appear for the first time or are isolated. Clinical Description: A 12-year-old girl presented with acute pain and progressive weakness of both lower limbs for 12 days, followed by diffuse abdominal pain and low-grade fever. Salient neurological findings were diminished power and hyporeflexia in all limbs. Guillain–Barre syndrome was suspected in view of symmetric ascending paralysis and a suggestive nerve conduction study. The child had neutrophilic leukocytosis but sterile cultures. The successive development of inflammatory demyelinating polyneuropathy, persistent fever, vasculitic phenomena (hypertension, severe myalgia, rashes, multiple infarcts, acute renal cortical necrosis, and gangrene of the digit), and elevated acute-phase reactants was suggestive of a multisystemic small-vessel and medium-sized vasculitis syndrome, such as polyarteritis nodosa (PAN). A diagnosis of PAN was established based on the satisfaction of clinical criteria. Management: The patient was administered pulse methylprednisolone and oral steroids, with which there was a dramatic recovery. Monthly cyclophosphamide was continued in view of major systemic involvement. Conclusion: Early recognition and management of childhood vasculitis syndrome is associated with good outcomes

Weed Management and Crop Establishment Methods in Rice (<i>Oryza sativa</i> L.) Influence the Soil Microbial and Enzymatic Activity in Sub-Tropical Environment

Weed management has become the most important and inevitable aspect of crop management for achieving a higher rice yield. Nowadays, chemical herbicide application has become a popular practice for managing weeds in different rice cultures. However, herbicide application can have qualitative and quantitative impacts on soil microorganisms and soil enzymes, particularly in the case of new herbicide molecules and their indiscriminate use for a longer period. Further, different rice establishment methods also play a significant role in soil microbial population dynamics as well as soil biological properties. Keeping these in view, a field experiment was conducted at the Agronomy Main Research Farm, Orissa University of Agriculture and Technology (OUAT), India, during the kharif season of 2016 and 2017, on the impact of crop establishment methods and weed management practices on soil microbial and enzymatic status. The field experiment was laid out in a split-plot design with three replications with four crop establishment methods in the main plot, viz., M1, Direct Seeded Rice (DSR); M2, Wet Seeded Rice (WSR); M3,Unpuddled Transplanted Rice (NPTR); M4, Puddled Transplanted Rice (PTR), and six weed management practices in the sub-plot, viz., W1, Weedy check; W2, Bensulfuron methyl 0.6% + Pretilachlor 6% (pre-emergence (PE)) 0.660 kg ha−1 + Hand weeding (HW) at 30 days after sowing/transplanting (days after sowing/transplanting (DAS/T)); W3, Bensulfuron methyl 0.6% + Pretilachlor 6% (PE) 0.495 kg ha−1 + HW at 30 DAS/T; W4, Bensulfuron methyl 0.6% + Pretilachlor 6% (PE) 0.495 kg ha−1 + Bispyribac-Sodium (post-emergence(POE)) 0.025 kg ha−1 at 15 DAS/T; W5, Cono weeding (CW) at 15 DAS/T + hand weeding 30 DAS/T, and W6, Brown manuring/Green manuring. The initial decline in the microbial population was observed due to herbicide application in NPTR and PTR up to 7 DAS/T and then it increased up to 28 DAS/T. There was a reduction in soil microbial and enzymatic status after the application of herbicides Bensulfuron methyl 0.6% + Pretilachlor 6% (PE) and Bispyribac-Sodium (POE) that again followed an upward graph with crop age. Significant variation in enzymatic activity and the microbial count was also observed among treatments involving crop establishment methods. The study revealed that improved microbial population and enzyme activity were noted in unpuddled transplanted rice under organic weed management due to favorable conditions, and chemical weed control initially affected microbial population and activities

Assessment of the recurrent mutagenesis efficacy of sesame crosses followed by isolation and evaluation of promising genetic resources for use in future breeding programs

The primary causes of low sesame production are a lack of high-yielding varieties, an inability to adjust to environmental challenges, and a poor response to enhanced crop management. The potential for improving sesame has been investigated using a variety of breeding approaches, including mutation and recombination breeding; however, these methods have only produced a minor increase in productivity. Recombination and mutant breeding have recently been proposed as novel, cutting-edge approaches to overcome the limitations of conventional breeding practices. This study was conducted to assess the recurrent mutagenesis efficacy of sesame crosses, followed by the isolation and evaluation of superior breeding lines that could be released as varieties in the future. In the F4M4 generation, the populations were grown in a randomized block design (RBD), and the efficacy of recurrent mutagenesis was assessed in terms of variability parameters such as the mean, standard deviation, and coefficient of variation. During the F5M5 generation, the materials were grown in three separate trials in Compact Family Block Design to evaluate the between-family and within-family variations, followed by the isolation of improved breeding lines based on per se performance. The improved breeding lines were further advanced to the F6M6 generation for evaluation in three separate trials in an RBD. In the F6M6 generation, ANOVA, correlation, regression, path coefficient, and Mahalanobis’s D 2 analysis were computed, followed by the construction of selection indices to select superior lines. The results showed the importance of three or four EMS treatment cycles for sesame improvement in the F4M4 generation. Twenty of the top lines based on per se performance (with a selection intensity of 27%) from each category in the F5M5 generation were carried forward to the F6M6 generation. In the F6M6 generation, the top six breeding lines (with a selection intensity of 30%) from each category, for a total of 18 breeding lines, were chosen based on these index scores. These high-yielding micromutant lines could be subsequently released as varieties through multiplication trials with standard checks. After a thorough evaluation, these lines have the potential to replace the current varieties and increase production, productivity, and adoption of sesame in India