MRI to determine the chronological age of Ghanaian footballers

Background. The chronological age of the ordinary Ghanaian has often been difficult to verify as registration at birth is not compulsory. Consequently, an accurate method of age determination is needed in competitive age-restricted sports.Objective. To evaluate the age of Ghanaian soccer players who are aspiring to play for the national under-17 (U17) team, using the degree of fusion of the distal radius on magentic resonance imaging (MRI) and comparing it with the Fédération Internationale de Football Association (FIFA) MRI grading.Methods. MRI scans of the left wrists of 86 players aspiring to play for the national U17 football team were recruited for the study during a ‘justify your inclusion tournament’ organised by the Ghana Football Association between June and August 2012. The study was conducted in a diagnostic centre in Accra using a 0.35T MRI scanner. The images were analysed using the previously published FIFA grading system.Results. The mean chronological age of the players was 15.4 years (standard deviation ±0.7; range 12 - 17). The study showed that 43.0% of the MRI images were grade 6 (≥17 years) in relation to the degree of fusion of the distal radius, and 93.0% of the grade 6 players were aged 15 - 16 years chronologically. There was no significant correlation between the chronological age and the degree of fusion (r=0.075; p=0.493).Conclusion. Ghanaian U17 soccer players seem to be more biologically mature than a normative population of the same age category. The lack of correlation between age category and degree of fusion supports the suspicion that most Ghanaian players may not know their true age

Spatial Analysis of Land Cover Determinants of Malaria Incidence in the Ashanti Region, Ghana

Malaria belongs to the infectious diseases with the highest morbidity and mortality worldwide. As a vector-borne disease malaria distribution is strongly influenced by environmental factors. The aim of this study was to investigate the association between malaria risk and different land cover classes by using high-resolution multispectral Ikonos images and Poisson regression analyses. The association of malaria incidence with land cover around 12 villages in the Ashanti Region, Ghana, was assessed in 1,988 children <15 years of age. The median malaria incidence was 85.7 per 1,000 inhabitants and year (range 28.4–272.7). Swampy areas and banana/plantain production in the proximity of villages were strong predictors of a high malaria incidence. An increase of 10% of swampy area coverage in the 2 km radius around a village led to a 43% higher incidence (relative risk [RR] = 1.43, p<0.001). Each 10% increase of area with banana/plantain production around a village tripled the risk for malaria (RR = 3.25, p<0.001). An increase in forested area of 10% was associated with a 47% decrease of malaria incidence (RR = 0.53, p = 0.029)

Trichomonas vaginalis: Clinical relevance, pathogenicity and diagnosis

Trichomonas vaginalis is the etiological agent of trichomoniasis, the most prevalent non-viral sexually transmitted disease worldwide. Trichomoniasis is a widespread, global health concern and occurring at an increasing rate. Infections of the female genital tract can cause a range of symptoms, including vaginitis and cervicitis, while infections in males are generally asymptomatic. The relatively mild symptoms, and lack of evidence for any serious sequelae, have historically led to this disease being under diagnosed, and under researched. However, growing evidence that T. vaginalis infection is associated with other disease states with high morbidity in both men and women has increased the efforts to diagnose and treat patients harboring this parasite. The pathology of trichomoniasis results from damage to the host epithelia, caused by a variety of processes during infection and recent work has highlighted the complex interactions between the parasite and host, commensal microbiome and accompanying symbionts. The commercial release of a number of nucleic acid amplification tests (NAATs) has added to the available diagnostic options. Immunoassay based Point of Care testing is currently available, and a recent initial evaluation of a NAAT Point of Care system has given promising results, which would enable testing and treatment in a single visit