6 research outputs found
A novel way of constraining the -attractor chaotic inflation through Planck data
Defining a scale of -modes of the quantum fluctuations during inflation
through the dynamical horizon crossing condition we go from the
physical variable to variable and solve the equations of cosmological
first-order perturbations self consistently, with the chaotic
-attractor type potentials. This enables us to study the behaviour of
, , and in the -space. Comparison of our results in
the low- regime with the Planck data puts constraints on the values of the
parameter through microscopic calculations. Recent studies had already
put model-dependent constraints on the values of through the
hyperbolic geometry of a Poincar\'{e} disk: consistent with both the maximal
supergravity model and the minimal supergravity model
, the constraints on the values of are ,
, 1, , , 2, . The minimal
supersymmetric cosmological models with -mode targets,
derived from these supergravity models, predicted the values of between
and . Both in the -model and the -model potentials, we
have obtained, in our calculations, the values of in this range for all the
constrained values of stated above, within CL. Moreover, we
have calculated for some other possible values of both in
low- limit, using the formula , and in the
high- limit, using the formula , for and .
With all such values of , our calculated results match with the
Planck-2018 data with or near CL.Comment: 41 pages, 29 figures, expanded the abstract, added figures and
references, enlarged the discussio
Non-perturbative stabilization of two Kähler moduli in type-IIB/F theory and the inflaton potential
We consider a combination of perturbative and non-perturbative corrections in Kähler moduli stabilizations in the configuration of three magnetised intersecting D7 branes in the type-IIB/F theory, compactified on the 6d orbifold of Calabi-Yau three-fold (CY3). Two of the Kähler moduli are stabilized non-perturbatively, out of the three which get perturbative corrections up to one-loop–order multi-graviton scattering amplitudes in the large volume scenario. In this framework, the dS vacua are achieved through all Kähler moduli stabilizations by considering the D-term. We obtain inflaton potentials of slow-roll plateau type, which are expected by recent cosmological observations. Calculations of cosmological parameters with the potentials yield experimentally favoured values
Single-field slow-roll effective potential from Kähler moduli stabilizations in type-IIB/F-theory
We derive a single-field slow-roll inflaton potential in three-intersecting-D7-branes configuration under type-IIB/F-theory compactification. Among three resulting Kähler moduli corresponding to three orthogonal directions, two are stabilized via perturbative corrections in the Kähler potential arising from the large-volume scenario and four-graviton scattering amplitude up to one loop level and the remaining Kähler modulus is stabilized by KKLT-type non-perturbative correction in superpotential. The symmetric combination of two canonically normalized and perturbatively stabilized Kähler moduli gives the inflaton field and the anti-symmetric combination manifests itself as an auxiliary field
CryoFold: Determining protein structures and data-guided ensembles from cryo-EM density maps
Cryo-electron microscopy (EM) requires molecular modeling to refine structural details from data. Ensemble models arrive at low free-energy molecular structures, but are computationally expensive and limited to resolving only small proteins that cannot be resolved by cryo-EM. Here, we introduce CryoFold - a pipeline of molecular dynamics simulations that determines ensembles of protein structures directly from sequence by integrating density data of varying sparsity at 3-5 Ã… resolution with coarse-grained topological knowledge of the protein folds. We present six examples showing its broad applicability for folding proteins between 72 to 2000 residues, including large membrane and multi-domain systems, and results from two EMDB competitions. Driven by data from a single state, CryoFold discovers ensembles of common low-energy models together with rare low-probability structures that capture the equilibrium distribution of proteins constrained by the density maps. Many of these conformations, unseen by traditional methods, are experimentally validated and functionally relevant. We arrive at a set of best practices for data-guided protein folding that are controlled using a Python GUI